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Cited by 802

The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.

Management of Neonates With Suspected or Proven Early-Onset Bacterial Sepsis

Polin, Richard A., the COMMITTEE ON FETUS AND NEWBORN, Papile, Lu-Ann, Baley, Jill E., Bhutani, Vinod K., Carlo, Waldemar A., Cummings, James, Kumar, Praveen, Tan, Rosemarie C., Wang, Kasper S., Watterberg, Kristi L.·2012·Pediatrics
DOI 10.1542/peds.2012-0541
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Abstract

With improved obstetrical management and evidence-based use of intrapartum antimicrobial therapy, early-onset neonatal sepsis is becoming less frequent. However, early-onset sepsis remains one of the most common causes of neonatal morbidity and mortality in the preterm population. The identification of neonates at risk for early-onset sepsis is frequently based on a constellation of perinatal risk factors that are neither sensitive nor specific. Furthermore, diagnostic tests for neonatal sepsis have a poor positive predictive accuracy. As a result, clinicians often treat well-appearing infants for extended periods of time, even when bacterial cultures are negative. The optimal treatment of infants with suspected early-onset sepsis is broad-spectrum antimicrobial agents (ampicillin and an aminoglycoside). Once a pathogen is identified, antimicrobial therapy should be narrowed (unless synergism is needed). Recent data suggest an association between prolonged empirical treatment of preterm infants (≥5 days) with broad-spectrum antibiotics and higher risks of late onset sepsis, necrotizing enterocolitis, and mortality. To reduce these risks, antimicrobial therapy should be discontinued at 48 hours in clinical situations in which the probability of sepsis is low. The purpose of this clinical report is to provide a practical and, when possible, evidence-based approach to the management of infants with suspected or proven early-onset sepsis.

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Metadata

Authors
Polin, R. A., the COMMITTEE ON FETUS AND NEWBORN, Papile, L.-A., Baley, J. E., Bhutani, V. K., Carlo, W. A., Cummings, J., Kumar, P., Tan, R. C., Wang, K. S., & Watterberg, K. L.
Venue
Pediatrics
Publisher
American Academy of Pediatrics (AAP)
Published
2012-05-01
Volume
129
Issue
5
Pages
1006-1015
ISSN
  • 0031-4005 (ISSN-L)
  • 1098-4275
DOI
10.1542/peds.2012-0541
OpenAlex
W2167696296
Cited by
802
References
61
FWCI
38.20
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Management of Neonates With Suspected or Proven Early-Onset Bacterial Sepsis. https://app.cochat.ai/papers/10.1542/peds.2012-0541
The paper
Polin, R. A., the COMMITTEE ON FETUS AND NEWBORN, Papile, L.-A., Baley, J. E., Bhutani, V. K., Carlo, W. A., Cummings, J., Kumar, P., Tan, R. C., Wang, K. S., & Watterberg, K. L. (2012). Management of Neonates With Suspected or Proven Early-Onset Bacterial Sepsis. Pediatrics. https://doi.org/10.1542/peds.2012-0541

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.