Bacterial Meningitis in Infants

Ku, Lawrence C.; Boggess, Kim A.; Cohen-Wolkowiez, Michael

doi:10.1016/j.clp.2014.10.004

Cited by 268Neonatal and Maternal InfectionsBacterial Infections and VaccinesBacterial Identification and Susceptibility Testing

Bacterial Meningitis in Infants

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Ku, Lawrence C., Boggess, Kim A., Cohen-Wolkowiez, Michael·2015·Clinics in Perinatology

DOI 10.1016/j.clp.2014.10.004PMC PMC4332563

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Abstract

Neonatal bacterial meningitis is uncommon but devastating. Morbidity among survivors remains high. The types and distribution of pathogens are related to gestational age, postnatal age, and geographic region. Confirming the diagnosis is difficult. Clinical signs are often subtle, lumbar punctures are frequently deferred, and cerebrospinal fluid (CSF) cultures can be compromised by prior antibiotic exposure. Infants with bacterial meningitis can have negative blood cultures and normal CSF parameters. Promising tests such as the polymerase chain reaction require further study. Prompt treatment with antibiotics is essential. Clinical trials investigating a vaccine for preventing neonatal Group B Streptococcus infections are ongoing.

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The FilmArray ME panel detects many of the common pathogens of neonatal meningitis, including group B streptococcus and E. coli K1.
“While the FilmArray ME panel detects many of the common pathogens of neonatal meningitis (3), including group B streptococcus and E. coli K1”
From Retrospective Evaluation of Infants Aged 1 to 60 Days with Residual Cerebrospinal Fluid (CSF) Tested Using the FilmArray Meningitis/Encephalitis (ME) Panel (2018) · cites this paper as [3]
The Etiology > Early-Onset Meningitis section (page unavailable) identifies group B streptococcus and E. coli as common causes of neonatal meningitis. The Diagnosis > Ancillary Tests section discusses a different PCR assay, not the FilmArray ME panel, and the copy does not specify E. coli K1. It therefore supports the pathogen-background portion of the claim, but not the panel-detection or K1-specific portions. (LLM, conf=0.86)
Experimental — accuracy not yet measured
Only six bacterial pathogens are represented on the FilmArray ME panel, and early neonatal pathogens such as other E. coli serotypes and Citrobacter spp. are not included.
“only six bacterial pathogens are represented, and early neonatal pathogens such as other E. coli serotypes and Citrobacter spp. are not included.”
From Retrospective Evaluation of Infants Aged 1 to 60 Days with Residual Cerebrospinal Fluid (CSF) Tested Using the FilmArray Meningitis/Encephalitis (ME) Panel (2018) · cites this paper as [3]
The Etiology > Early-Onset Meningitis section identifies E. coli as an early-onset pathogen, but does not discuss E. coli serotypes or which pathogens a diagnostic panel includes. The Diagnosis > Ancillary Tests section describes a different PCR assay; searches for FilmArray ME and Citrobacter found no passage addressing the panel’s six-pathogen count or its exclusions. Page numbers were not available in our copy. (LLM, conf=0.76)
Experimental — accuracy not yet measured

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Authors: Ku, L. C., Boggess, K. A., & Cohen-Wolkowiez, M.
Affiliations: Duke Clinical Research Institute (US)
University of North Carolina at Chapel Hill (US)
ORCID: Ku, Lawrence C.
Boggess, Kim A.
Venue: Clinics in Perinatology
Publisher: Elsevier BV
Published: 2015-03
Volume: 42
Issue: 1
Pages: 29-45
ISSN: 0095-5108 (ISSN-L)
DOI: 10.1016/j.clp.2014.10.004
PMC: PMC4332563
OpenAlex: W2038254536
Cited by: 268
References: 76
Citations by year: 2026: 18 · 2025: 22 · 2024: 35 · 2023: 45 · 2022: 27 · 2021: 38 · 2020: 28 · 2019: 24 · 2018: 16 · 2017: 8 · 2016: 5 · 2015: 2
FWCI: 0.78
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Clinics in Perinatology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
UNC Libraries
Funders: National Institutes of Health (UL1TR001117, UL1TR001111, UL1TR002489, HHSO100201300009C, 1U01FD004858-01)
U.S. Food and Drug Administration (U01 FD004858, 1u01fd004858-01)
Biomedical Advanced Research and Development Authority (UL1TR001117, HHSO100201300009C, 1U01FD004858-01)
National Institute of General Medical Sciences (T32GM086330)
National Institute of Child Health and Human Development (HHSO100201300009C, 1U01FD004858-01)
National Center for Advancing Translational Sciences (HHSO100201300009C, 1U01FD004858-01)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD064729, T32HD040672, K12HD001441, K12HD043494)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Neonatal and Maternal Infections
Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Bacterial Identification and Susceptibility Testing
Keywords: neonatal bacterial meningitis, infants, Streptococcus agalactiae, cerebrospinal fluid culture, prior antibiotic use, diagnostic challenges, gestational age, postnatal age, antibiotic therapy, meningitis vaccine
MeSH terms: Anti-Bacterial Agents, Bacterial Vaccines, Escherichia coli Infections, Gestational Age, Humans, Infant, Infant, Newborn, Spinal Puncture, Streptococcal Infections, Streptococcus agalactiae, Meningitis, Bacterial, Infant, Very Low Birth Weight, Culture Techniques

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Bacterial Meningitis in Infants

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