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Cited by 260

The DOI matches its Crossref record; 127 of the 127 references it cites were found in a registry or an index.

Evidence-Based Recommendations for the Diagnosis and Treatment of Pediatric Acne

Eichenfield, Lawrence F., Krakowski, Andrew C., Piggott, Caroline, Del Rosso, James, Baldwin, Hilary, Friedlander, Sheila Fallon, Levy, Moise, Lucky, Anne, Mancini, Anthony J., Orlow, Seth J., Yan, Albert C., Vaux, Keith K., Webster, Guy, Zaenglein, Andrea L., Thiboutot, Diane M.·2013·Pediatrics
DOI 10.1542/peds.2013-0490b
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Abstract

INTRODUCTION: Acne vulgaris is one of the most common skin conditions in children and adolescents. The presentation, differential diagnosis, and association of acne with systemic pathology differs by age of presentation. Current acknowledged guidelines for the diagnosis and management of pediatric acne are lacking, and there are variations in management across the spectrum of primary and specialty care. The American Acne and Rosacea Society convened a panel of pediatric dermatologists, pediatricians, and dermatologists with expertise in acne to develop recommendations for the management of pediatric acne and evidence-based treatment algorithms. METHODS: Ten major topic areas in the diagnosis and treatment of pediatric acne were identified. A thorough literature search was performed and articles identified, reviewed, and assessed for evidence grading. Each topic area was assigned to 2 expert reviewers who developed and presented summaries and recommendations for critique and editing. Furthermore, the Strength of Recommendation Taxonomy, including ratings for the strength of recommendation for a body of evidence, was used throughout for the consensus recommendations for the evaluation and management of pediatric acne. Practical evidence-based treatment algorithms also were developed. RESULTS: Recommendations were put forth regarding the classification, diagnosis, evaluation, and management of pediatric acne, based on age and pubertal status. Treatment considerations include the use of over-the-counter products, topical benzoyl peroxide, topical retinoids, topical antibiotics, oral antibiotics, hormonal therapy, and isotretinoin. Simplified treatment algorithms and recommendations are presented in detail for adolescent, preadolescent, infantile, and neonatal acne. Other considerations, including psychosocial effects of acne, adherence to treatment regimens, and the role of diet and acne, also are discussed. CONCLUSIONS: These expert recommendations by the American Acne and Rosacea Society as reviewed and endorsed by the American Academy of Pediatrics constitute the first detailed, evidence-based clinical guidelines for the management of pediatric acne including issues of special concern when treating pediatric patients.

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Research works printed but not linked: 42

  1. Krakowski, 2007, Pediatric acne: clinical presentations, evaluation, and management., J Drugs Dermatol, 6, 589
  2. Marcoux, 1998, Prepubertal acne: clinical presentation, evaluation, and treatment., J Cutan Med Surg, 2, 2
  3. Cunliffe, 2001, A clinical and therapeutic study of 29 patients with infantile acne., Br J Dermatol, 145, 463, 10.1046/j.1365-2133.2001.04397.x · doi:10.1046/j.1365-2133.2001.04397.x
  4. Demircay, 2008, Patient’s perspective: an important issue not to be overlooked in assessing acne severity., Eur J Dermatol, 18, 181
  5. Breneman, 1993, Successful treatment of acne vulgaris in women with a new topical sodium sulfacetamide/sulfur lotion., Int J Dermatol, 32, 365, 10.1111/j.1365-4362.1993.tb01476.x · doi:10.1111/j.1365-4362.1993.tb01476.x
  6. Kligman, 1995, Acne vulgaris: tricks and treatments. Part II: the benzoyl peroxide saga., Cutis, 56, 260
  7. Shalita, 2003, Compared efficacy and safety of tretinoin 0.1% microsphere gel alone and in combination with benzoyl peroxide 6% cleanser for the treatment of acne vulgaris., Cutis, 72, 167
  8. Mohd Nor, A systematic review of benzoyl peroxide for acne vulgaris [published online ahead of print July 25, 2012]., J Dermatolog Treat
  9. Leyden, 1996, The antimicrobial effects in vivo of minocycline, doxycycline and tetracycline in humans., J Dermatolog Treat, 7, 223, 10.3109/09546639609089553 · doi:10.3109/09546639609089553
  10. Amin, 2007, Common and alternate oral antibiotic therapies for acne vulgaris: a review., J Drugs Dermatol, 6, 873
  11. Bjellerup, 1987, Double blind cross-over studies on phototoxicity to three tetracycline derivatives in human volunteers., Photodermatol, 4, 281
  12. Vãlean, 2005, Pill esophagitis., Rom J Gastroenterol, 14, 159
  13. Kadayifci, 2004, Doxycycline-induced pill esophagitis., Dis Esophagus, 17, 168, 10.1111/j.1442-2050.2004.00384.x · doi:10.1111/j.1442-2050.2004.00384.x
  14. Järvinen, 1995, Enteric coating reduces upper gastrointestinal adverse reactions to doxycycline., Clin Drug Investig, 10, 323, 10.2165/00044011-199510060-00002 · doi:10.2165/00044011-199510060-00002
  15. Geria, 2009, Minocycline-induced skin pigmentation: an update., Acta Dermatovenerol Croat, 17, 123
  16. Gordon, 1985, Hyperpigmentation of the skin associated with minocycline therapy., Arch Dermatol, 121, 618, 10.1001/archderm.1985.01660050070017 · doi:10.1001/archderm.1985.01660050070017
  17. Treister, 2004, Oral mucosal pigmentation secondary to minocycline therapy: report of two cases and a review of the literature., Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 97, 718, 10.1016/j.tripleo.2003.11.006 · doi:10.1016/j.tripleo.2003.11.006
  18. Plott, 2006, Key bioavailability features of a new extended-release formulation of minocycline hydrochloride tablets., Cutis, 78, 6
  19. Del Rosso, 2000, Systemic therapy for rosacea: focus on oral antibiotic therapy and safety., Cutis, 66, 7
  20. Tsankov, 2003, Tetracyclines in dermatology., Clin Dermatol, 21, 33, 10.1016/S0738-081X(02)00324-3 · doi:10.1016/s0738-081x(02)00324-3
  21. Del Rosso, 2006, Clinical significance of brand versus generic formulations: focus on oral minocycline., Cutis, 77, 153
  22. Friedman, 2005, Medication-induced intracranial hypertension in dermatology., Am J Clin Dermatol, 6, 29, 10.2165/00128071-200506010-00004 · doi:10.2165/00128071-200506010-00004
  23. Raimer, 2008, Efficacy and safety of dapsone gel 5% for the treatment of acne vulgaris in adolescents., Cutis, 81, 171
  24. Melki, 2001, Granulomatous colitis likely induced by isotretinoin [in French], Gastroenterol Clin Biol, 25, 433
  25. Deplaix, 1996, Probable acute hemorrhagic colitis caused by isotretinoin with a test of repeated administration [in French], Gastroenterol Clin Biol, 20, 113
  26. Brodin, 1986, Inflammatory bowel disease and isotretinoin., J Am Acad Dermatol, 14, 843, 10.1016/S0190-9622(86)80535-7 · doi:10.1016/s0190-9622(86)80535-7
  27. Nishimura, 1997, Generalized metaphyseal modification with cone-shaped epiphyses following long-term administration of 13-cis-retinoic acid., Eur J Pediatr, 156, 432, 10.1007/s004310050631 · doi:10.1007/s004310050631
  28. Tekin, 2008, Bone mineral density and bone turnover markers in patients receiving a single course of isotretinoin for nodulocystic acne., Int J Dermatol, 47, 622, 10.1111/j.1365-4632.2008.03534.x · doi:10.1111/j.1365-4632.2008.03534.x
  29. Vestergaard, 2010, High-dose treatment with vitamin A analogues and risk of fractures., Arch Dermatol, 146, 478, 10.1001/archdermatol.2010.59 · doi:10.1001/archdermatol.2010.59
  30. Milstone, 1982, Premature epiphyseal closure in a child receiving oral 13-cis-retinoic acid., J Am Acad Dermatol, 7, 663, 10.1016/S0190-9622(82)70148-3 · doi:10.1016/s0190-9622(82)70148-3
  31. Inamo, 1999, A case of growth failure caused by 13-CIS-retinoic acid administration after bone marrow transplantation for neuroblasoma., Endocr J, 46, S113, 10.1507/endocrj.46.Suppl_S113 · doi:10.1507/endocrj.46.suppl_s113
  32. Schleicher, 1985, Oral isotretinoin and inflammatory bowel disease., J Am Acad Dermatol, 13, 834, 10.1016/S0190-9622(85)80411-4 · doi:10.1016/s0190-9622(85)80411-4
  33. Macdonald Hull, 1989, The safety of isotretinoin in patients with acne and systemic diseases., J Dermatolog Treat, 1, 35, 10.3109/09546638909086687 · doi:10.3109/09546638909086687
  34. McHenry, 1992, Pyoderma faciale in a patient with Crohn’s disease., Clin Exp Dermatol, 17, 460, 10.1111/j.1365-2230.1992.tb00262.x · doi:10.1111/j.1365-2230.1992.tb00262.x
  35. Velez, 1995, Pyoderma gangrenosum associated with acne conglobata., Clin Exp Dermatol, 20, 496, 10.1111/j.1365-2230.1995.tb01387.x · doi:10.1111/j.1365-2230.1995.tb01387.x
  36. Rosen, 1999, Treatment of pyoderma faciale with isotretinoin in a patient with ulcerative colitis., Cutis, 64, 107
  37. Gatzka, 2006, Rosacea fulminans, pyostomatitis and pyovulvitis in Crohn’s disease: dapsone as key factor in combination therapy [in German], Hautarzt, 57, 898, 10.1007/s00105-005-1017-3 · doi:10.1007/s00105-005-1017-3
  38. Guslandi, 2007, Isotretinoin and inflammatory bowel disease., Am J Gastroenterol, 102, 1546, 10.1111/j.1572-0241.2007.01267.x · doi:10.1111/j.1572-0241.2007.01267.x
  39. Eichenfield, 2010, Treatment of 2,453 acne vulgaris patients aged 12-17 years with the fixed-dose adapalene-benzoyl peroxide combination topical gel: efficacy and safety., J Drugs Dermatol, 9, 1395
  40. Del Rosso, 2007, Study results of benzoyl peroxide 5%/clindamycin 1% topical gel, adapalene 0.1% gel, and use in combination for acne vulgaris., J Drugs Dermatol, 6, 616
  41. Yan, 2008, Beyond first-line treatment: management strategies for maintaining acne improvement and compliance., Cutis, 82, 18
  42. Patel, 2011, Medication choice and associated health care outcomes and costs for patients with acne and acne-related conditions in the United States., J Drugs Dermatol, 10, 766

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Metadata

Authors
Eichenfield, L. F., Krakowski, A. C., Piggott, C., Del Rosso, J., Baldwin, H., Friedlander, S. F., Levy, M., Lucky, A., Mancini, A. J., Orlow, S. J., Yan, A. C., Vaux, K. K., Webster, G., Zaenglein, A. L., & Thiboutot, D. M.
Venue
Pediatrics
Publisher
American Academy of Pediatrics (AAP)
Published
2013-05-01
Volume
131
Issue
Supplement_3
Pages
S163-S186
ISSN
  • 0031-4005 (ISSN-L)
  • 1098-4275
DOI
10.1542/peds.2013-0490b
OpenAlex
W1999031380
Cited by
260
References
127
FWCI
22.00
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Evidence-Based Recommendations for the Diagnosis and Treatment of Pediatric Acne. https://app.cochat.ai/papers/10.1542/peds.2013-0490b
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Eichenfield, L. F., Krakowski, A. C., Piggott, C., Del Rosso, J., Baldwin, H., Friedlander, S. F., Levy, M., Lucky, A., Mancini, A. J., Orlow, S. J., Yan, A. C., Vaux, K. K., Webster, G., Zaenglein, A. L., & Thiboutot, D. M. (2013). Evidence-Based Recommendations for the Diagnosis and Treatment of Pediatric Acne. Pediatrics. https://doi.org/10.1542/peds.2013-0490b

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