The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Early Neonatal Bilirubin, Hematocrit, and Glucose-6-Phosphate Dehydrogenase Status
Abstract
OBJECTIVE: To document the patterns of bilirubin and hematocrit values among glucose-6-phosphate dehydrogenase (G6PD)-deficient and G6PD-normal Nigerian neonates in the first week of life, in the absence of exposure to known icterogenic agents. METHODS: The G6PD status of consecutive term and near-term neonates was determined, and their bilirubin levels and hematocrits were monitored during the first week of life. Infants were stratified into G6PD deficient, intermediate, and normal on the basis of the modified Beutler’s fluorescent spot test. Means of total serum bilirubin (TSB) and hematocrits of the 3 groups of infants were compared. RESULTS: The 644 neonates studied comprised 353 (54.8%) boys and 291 (45.2%) girls and 540 (83.9%) term and 104 (16.1%) near-term infants. They consisted of 129 (20.0%) G6PD-deficient, 69 (10.7%) G6PD-intermediate, and 446 (69.3%) G6PD-normal neonates. The G6PD-deficient and G6PD-intermediate infants had higher mean TSB than their G6PD-normal counterparts at birth and throughout the first week of life (P < .001). Mean peak TSB levels were 14.1 (9.48), 10.2 (3.8), and 6.9 (3.3) mg/dL for G6PD-deficient, G6PD-intermediate, and G6PD-normal neonates, respectively. Peak TSB was attained on approximately day 4 in all 3 groups, and trends in TSB were similar. Mean hematocrits at birth were similar in the 3 G6PD groups. However, G6PD-deficient and -intermediate infants had higher declines in hematocrit, bilirubin levels, and need for phototherapy than G6PD-normal infants (P < .001). CONCLUSIONS: The G6PD-deficient and G6PD-intermediate neonates had a higher risk of neonatal hyperbilirubinemia and would therefore need greater monitoring in the first week of life, even without exposure to known icterogenic agents.
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Kernicterus and severe hyperbilirubinemia are strongly associated with G6PD deficiency and can be exacerbated by haemolytic agents such as menthol and naphthalene.
“Kernicterus and severe hyperbilirubinemia are strongly associated with glucose-6-phosphate dehydrogenase (G6PD) deficiency [6, 16] and can be exacerbated by haemolytic agents such as menthol and naphthalene [17–20].”
From A Survey of Practice and Knowledge of Refugee and Migrant Pregnant Mothers Surrounding Neonatal Jaundice on the Thailand–Myanmar Border (2017) · cites this paper as [16]
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Research works printed but not linked: 3
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Prins, T. J., Trip-Hoving, M., Paw, M. K., Ka, M. L., Win, N. N., Htoo, G., Hser, M. K., Chotivanich, K., Nosten, F., & McGready, R. (2017) · Journal of Tropical Pediatrics · doi:10.1093/tropej/fmw055 · Cited by 12
Metadata
- Authors
- Badejoko, B. O., Owa, J. A., Oseni, S. B. A., Badejoko, O., Fatusi, A. O., & Adejuyigbe, E. A.
- Affiliations
- Departments of Paediatrics,
- Institute Of Perinatology Obstetrics And Gynaecology (AM)
- Obafemi Awolowo University Teaching Hospitals Complex (NG)
- Venue
- Pediatrics
- Publisher
- American Academy of Pediatrics (AAP)
- Published
- 2014-10-01
- Volume
- 134
- Issue
- 4
- Pages
- e1082-e1088
- ISSN
- 0031-4005 (ISSN-L)
- 1098-4275
- OpenAlex
- W2040975424
- Cited by
- 24
- References
- 15
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 5 · 2018: 3 · 2017: 2 · 2016: 3
- FWCI
- 1.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- PEDIATRICS (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal Health and Biochemistry
- Health Sciences › Medicine › Surgery › Pediatric Hepatobiliary Diseases and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
- Keywords
- glucose-6-phosphate dehydrogenase deficiency, neonatal hyperbilirubinemia, total bilirubin, neonatal hematocrit, phototherapy, neonatal jaundice, term and near-term neonates
- MeSH terms
- Age Factors, Bilirubin, Female, Follow-Up Studies, Glucosephosphate Dehydrogenase, Glucosephosphate Dehydrogenase Deficiency, Hematocrit, Humans, Infant, Newborn, Male, Nigeria, Prospective Studies, Biomarkers, Hyperbilirubinemia, Neonatal
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