CoChat
Sign Up
Cited by 367Viral Infections and Immunology ResearchSARS-CoV-2 and COVID-19 ResearchKawasaki Disease and Coronary Complications

The DOI matches its Crossref record; 17 of the 18 references it cites were found in a registry or an index.

Symptomatic Acute Myocarditis in 7 Adolescents After Pfizer-BioNTech COVID-19 Vaccination

Marshall, Mayme, Ferguson, Ian D., Lewis, Paul, Jaggi, Preeti, Gagliardo, Christina, Collins, James Stewart, Shaughnessy, Robin, Caron, Rachel, Fuss, Cristina, Corbin, Kathleen Jo E., Emuren, Leonard, Faherty, Erin, Hall, E. Kevin, Di Pentima, Cecilia, Oster, Matthew E., Paintsil, Elijah, Siddiqui, Saira, Timchak, Donna M., Guzman-Cottrill, Judith A.·2021·Pediatrics
DOI 10.1542/peds.2021-052478
Open this paper in CoChat — free account

Abstract

Trials of coronavirus disease 2019 (COVID-19) vaccination included limited numbers of children, so they may not have detected rare but important adverse events in this population. We report 7 cases of acute myocarditis or myopericarditis in healthy male adolescents who presented with chest pain all within 4 days after the second dose of Pfizer-BioNTech COVID-19 vaccination. Five patients had fever around the time of presentation. Acute COVID-19 was ruled out in all 7 cases on the basis of negative severe acute respiratory syndrome coronavirus 2 real-time reverse transcription polymerase chain reaction test results of specimens obtained by using nasopharyngeal swabs. None of the patients met criteria for multisystem inflammatory syndrome in children. Six of the 7 patients had negative severe acute respiratory syndrome coronavirus 2 nucleocapsid antibody assay results, suggesting no previous infection. All patients had an elevated troponin. Cardiac MRI revealed late gadolinium enhancement characteristic of myocarditis. All 7 patients resolved their symptoms rapidly. Three patients were treated with nonsteroidal antiinflammatory drugs only, and 4 received intravenous immunoglobulin and corticosteroids. In this report, we provide a summary of each adolescent’s clinical course and evaluation. No causal relationship between vaccine administration and myocarditis has been established. Continued monitoring and reporting to the US Food and Drug Administration Vaccine Adverse Event Reporting System is strongly recommended.

Overview

Integrity signals

Registry

Crossref · 10.1542/peds.2021-052478

Cites

17 of 17 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

1 retracted

Show all 18 references

Cited by

Sorted by citations

Items 101–200 of 367

Related

See all

Metadata

Authors
Marshall, M., Ferguson, I. D., Lewis, P., Jaggi, P., Gagliardo, C., Collins, J. S., Shaughnessy, R., Caron, R., Fuss, C., Corbin, K. J. E., Emuren, L., Faherty, E., Hall, E. K., Di Pentima, C., Oster, M. E., Paintsil, E., Siddiqui, S., Timchak, D. M., & Guzman-Cottrill, J. A.
Affiliations
  • Oregon Health & Science University (US)
  • Yale University (US)
  • Emory University (US)
  • Thomas Jefferson University (US)
  • Spectrum Health (US)
  • dGoryeb Children’s Hospital, Atlantic Health System, Morristown, New Jersey
  • Goryeb Children's Hospital (US)
  • Columbia University Irving Medical Center (US)
  • aDepartment of Pediatrics, Oregon Health and Science University, Portland, Oregon
ORCID
Venue
Pediatrics
Publisher
American Academy of Pediatrics (AAP)
Published
2021-09-01
Volume
148
Issue
3
ISSN
  • 0031-4005 (ISSN-L)
  • 1098-4275
DOI
10.1542/peds.2021-052478
OpenAlex
W3165142255
Cited by
367
References
18
Citations by year
2026: 6 · 2025: 17 · 2024: 22 · 2023: 52 · 2022: 163 · 2021: 107
FWCI
57.61
Type
journal article
Language
en
Open access
closed
Locations
  • PEDIATRICS (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Viral Infections and Immunology Research
  • Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Kawasaki Disease and Coronary Complications
Keywords
acute myocarditis, myopericarditis, COVID-19 vaccination, BNT162b2, adolescents, vaccine adverse events, late gadolinium enhancement, cardiac MRI, troponin elevation, intravenous immunoglobulin, corticosteroids, nonsteroidal anti-inflammatory drugs, vaccine safety
MeSH terms
COVID-19, Coronavirus Nucleocapsid Proteins, COVID-19 Vaccines, COVID-19 Nucleic Acid Testing, BNT162 Vaccine, Acute Disease, Adolescent, Gadolinium, Humans, Magnetic Resonance Imaging, Male, Myocarditis, Phosphoproteins, Time Factors, Troponin, Systemic Inflammatory Response Syndrome, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review