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Cited by 367Viral Infections and Immunology ResearchSARS-CoV-2 and COVID-19 ResearchKawasaki Disease and Coronary Complications

The DOI matches its Crossref record; 17 of the 18 references it cites were found in a registry or an index.

Symptomatic Acute Myocarditis in 7 Adolescents After Pfizer-BioNTech COVID-19 Vaccination

Marshall, Mayme, Ferguson, Ian D., Lewis, Paul, Jaggi, Preeti, Gagliardo, Christina, Collins, James Stewart, Shaughnessy, Robin, Caron, Rachel, Fuss, Cristina, Corbin, Kathleen Jo E., Emuren, Leonard, Faherty, Erin, Hall, E. Kevin, Di Pentima, Cecilia, Oster, Matthew E., Paintsil, Elijah, Siddiqui, Saira, Timchak, Donna M., Guzman-Cottrill, Judith A.·2021·Pediatrics
DOI 10.1542/peds.2021-052478
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Abstract

Trials of coronavirus disease 2019 (COVID-19) vaccination included limited numbers of children, so they may not have detected rare but important adverse events in this population. We report 7 cases of acute myocarditis or myopericarditis in healthy male adolescents who presented with chest pain all within 4 days after the second dose of Pfizer-BioNTech COVID-19 vaccination. Five patients had fever around the time of presentation. Acute COVID-19 was ruled out in all 7 cases on the basis of negative severe acute respiratory syndrome coronavirus 2 real-time reverse transcription polymerase chain reaction test results of specimens obtained by using nasopharyngeal swabs. None of the patients met criteria for multisystem inflammatory syndrome in children. Six of the 7 patients had negative severe acute respiratory syndrome coronavirus 2 nucleocapsid antibody assay results, suggesting no previous infection. All patients had an elevated troponin. Cardiac MRI revealed late gadolinium enhancement characteristic of myocarditis. All 7 patients resolved their symptoms rapidly. Three patients were treated with nonsteroidal antiinflammatory drugs only, and 4 received intravenous immunoglobulin and corticosteroids. In this report, we provide a summary of each adolescent’s clinical course and evaluation. No causal relationship between vaccine administration and myocarditis has been established. Continued monitoring and reporting to the US Food and Drug Administration Vaccine Adverse Event Reporting System is strongly recommended.

Overview

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Crossref · 10.1542/peds.2021-052478

Cites

17 of 17 references verified0 citation errors · 0 not checkable

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Metadata

Authors
Marshall, M., Ferguson, I. D., Lewis, P., Jaggi, P., Gagliardo, C., Collins, J. S., Shaughnessy, R., Caron, R., Fuss, C., Corbin, K. J. E., Emuren, L., Faherty, E., Hall, E. K., Di Pentima, C., Oster, M. E., Paintsil, E., Siddiqui, S., Timchak, D. M., & Guzman-Cottrill, J. A.
Affiliations
  • Oregon Health & Science University (US)
  • Yale University (US)
  • Emory University (US)
  • Thomas Jefferson University (US)
  • Spectrum Health (US)
  • dGoryeb Children’s Hospital, Atlantic Health System, Morristown, New Jersey
  • Goryeb Children's Hospital (US)
  • Columbia University Irving Medical Center (US)
  • aDepartment of Pediatrics, Oregon Health and Science University, Portland, Oregon
ORCID
Venue
Pediatrics
Publisher
American Academy of Pediatrics (AAP)
Published
2021-09-01
Volume
148
Issue
3
ISSN
  • 0031-4005 (ISSN-L)
  • 1098-4275
DOI
10.1542/peds.2021-052478
OpenAlex
W3165142255
Cited by
367
References
18
Citations by year
2026: 6 · 2025: 17 · 2024: 22 · 2023: 52 · 2022: 163 · 2021: 107
FWCI
57.61
Type
journal article
Language
en
Open access
closed
Locations
  • PEDIATRICS (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Viral Infections and Immunology Research
  • Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Kawasaki Disease and Coronary Complications
Keywords
acute myocarditis, myopericarditis, COVID-19 vaccination, BNT162b2, adolescents, vaccine adverse events, late gadolinium enhancement, cardiac MRI, troponin elevation, intravenous immunoglobulin, corticosteroids, nonsteroidal anti-inflammatory drugs, vaccine safety
MeSH terms
COVID-19, Coronavirus Nucleocapsid Proteins, COVID-19 Vaccines, COVID-19 Nucleic Acid Testing, BNT162 Vaccine, Acute Disease, Adolescent, Gadolinium, Humans, Magnetic Resonance Imaging, Male, Myocarditis, Phosphoproteins, Time Factors, Troponin, Systemic Inflammatory Response Syndrome, Young Adult

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