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A Decreased Incidence of Necrotizing Enterocolitis After Prenatal Glucocorticoid Therapy
Abstract
In a large multicentered, collaborative randomized and blinded trial utilizing antenatal corticosteroids, the goals included determining the effectiveness of these agents in accelerating lung maturation, as well as monitoring any short-term or long-term adverse effects of this treatment on the parturient, fetus, and/or infant. More than 100 specific items, pertaining to diagnoses, complications, and outcomes were recorded for the 696 mothers enrolled in the study and their 745 infants. A significantly decreased incidence of necrotizing enterocolitis (P = .002) was found in the infants treated with steroids. The possibility of accelerated intestinal maturation induced by antenatal maternal steroid therapy exists. This treatment regimen is particularly attractive as adverse aspects of steroid therapy at the dosage utilized have not been demonstrated.
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Citations
Cited by
Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth
Roberts, D., Brown, J., Medley, N., & Dalziel, S. R. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004454.pub3 · Cited by 2,806
Lin, H.-C., Su, B.-H., Chen, A.-C., Lin, T.-W., Tsai, C.-H., Yeh, T.-F., & Oh, W. (2005) · Pediatrics · doi:10.1542/peds.2004-1463 · Cited by 660
Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth
McGoldrick, E., Stewart, F., Parker, R., & Dalziel, S. R. (2020) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004454.pub4 · Cited by 614
Nanthakumar, N. N., Fusunyan, R. D., Sanderson, I., & Walker, W. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.11.6043 · Cited by 451
Nanthakumar, N. N., Young, C., Ko, J. S., Meng, D., Chen, J., Buie, T., & Walker, W. A. (2005) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00169.2004 · Cited by 79
Metadata
- Authors
- Bauer, C. R., Morrison, J. C., Poole, W. K., Korones, S. B., Boehm, J. J., Rigatto, H., & Zachman, R. D.
- Venue
- Pediatrics
- Publisher
- American Academy of Pediatrics (AAP)
- Published
- 1984-05-01
- Volume
- 73
- Issue
- 5
- Pages
- 682-688
- ISSN
- 0031-4005 (ISSN-L)
- 1098-4275
- OpenAlex
- W2216480922
- Cited by
- 200
- References
- 0
- FWCI
- 2.27
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Bauer, C. R., Morrison, J. C., Poole, W. K., Korones, S. B., Boehm, J. J., Rigatto, H., & Zachman, R. D. (1984). A Decreased Incidence of Necrotizing Enterocolitis After Prenatal Glucocorticoid Therapy. Pediatrics. https://doi.org/10.1542/peds.73.5.682
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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