Fatal rhabdomyolysis following influenza infection in a girl with familial carnitine palmityl transferase deficiency
Abstract
Severe rhabdomyolysis following an influenza B infection developed in a previously well 13-year-old girl. There was no history of trauma. Her course was complicated by episodes of severe hyperkalemia, hypocalcemia, hyperphosphatemia, and myoglobinuria. Renal failure, hypertension, and life-threatening arrhythmias developed; she died. Muscle biopsy revealed that this girl had carnitine palmityl transferase deficiency. An asymptomatic sister was demonstrated to have the same disorder. Although carnitine palmityl transferase deficiency is usually associated with mild bouts of rhabdomyolysis that become apparent only in adulthood, severe forms of this disorder may be seen in children. Life-threatening rhabdomyolysis and myoglobinuria may follow any infection associated with decreased intake. If carnitine palmityl transferase deficiency is diagnosed in a proband, other siblings should be evaluated so that proper preventative measures can be undertaken to help prevent the development of symptoms in susceptible individuals who have not been recognized to have the disease.
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Histological descriptions of influenza B-associated skeletal myopathy are remarkably similar to the cardiac pathology identified in several of the case patients in our series.
“Histological descriptions of influenza B-associated skeletal myopathy are remarkably similar to the cardiac pathology identified in several of the case patients in our series”
From Myocardial Injury and Bacterial Pneumonia Contribute to the Pathogenesis of Fatal Influenza B Virus Infection (2012) · cites this paper as [44]
Histological descriptions of influenza B-associated skeletal myopathy include randomly distributed foci of segmental hyaline degeneration and necrosis of individual fibers, often in the absence of any inflammatory infiltrates.
“include randomly distributed foci of segmental hyaline degeneration and necrosis of individual fibers, often in the absence of any inflammatory infiltrates [43,44]”
From Myocardial Injury and Bacterial Pneumonia Contribute to the Pathogenesis of Fatal Influenza B Virus Infection (2012) · cites this paper as [44]
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BackgroundEnfermedades relacionadas con la nutricion: déficit de carnitina
Pontón, R. A. (2005) · Dialnet (Universidad de la Rioja)
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- Authors
- Kelly, K. J., Garland, J. S., Tang, T. T., Shug, A. L., & Chusid, M. J.
- Affiliations
- Children's Hospital of Wisconsin (US)
- ORCID
- Kelly, Kevin J.
- Venue
- PEDIATRICS
- Publisher
- American Academy of Pediatrics (AAP)
- Published
- 1989-08-01
- Volume
- 84
- Issue
- 2
- Pages
- 312-316
- ISSN
- 0031-4005 (ISSN-L)
- 1098-4275
- OpenAlex
- W1497207921
- Cited by
- 49
- References
- 0
- Citations by year
- 2025: 1 · 2021: 1 · 2020: 1 · 2017: 1 · 2016: 1 · 2014: 1 · 2013: 2 · 2012: 2
- FWCI
- 2.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- PEDIATRICS (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Muscle and Compartmental Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Methemoglobinemia and Tumor Lysis Syndrome
- Keywords
- rhabdomyolysis, myoglobinuria, hyperkalemia, hypocalcemia, hyperphosphatemia, renal failure, cardiac arrhythmias, childhood onset
- MeSH terms
- Acyltransferases, Adolescent, Carnitine O-Palmitoyltransferase, Female, Humans, Influenza, Human, Muscles, Myoglobinuria, Influenza B virus, Rhabdomyolysis, Acute Kidney Injury
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