The DOI matches its Crossref record; 38 of the 40 references it cites were found in a registry or an index.
Hyperlipidemia
Abstract
Cardiovascular disease remains the top cause of morbidity and mortality in the United States. Atherosclerotic plaques are known to start in adolescence, and, therefore, young adults can be affected by coronary artery disease. Children with known risk factors, such as genetic predisposition, including familial hyperlipidemias, diabetes, and renal diseases, are at higher risk. With childhood obesity becoming an epidemic in certain parts of the United States, this problem is further highlighted as an important issue affecting children's health. There are unclear recommendations for pediatricians regarding cholesterol screening of pediatric populations, when to initiate hyperlipidemia treatment with statin therapy, and when to refer to a specialist for further management. This article reviews the epidemiology and pathophysiology of hyperlipidemia, recommendations for screening and types of screening, management (including pharmacology), prognosis, and prevention.
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“Hyperlipidemia constitutes a significant risk factor in the onset of cardiovascular diseases (Stewart et al., 2020).”
From Lactiplantibacillus plantarum N4 ameliorates lipid metabolism and gut microbiota structure in high fat diet-fed rats (2024) · cites this paper as Stewart et al., 2020
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Cites
Kavey, R., Simons-Morton, D., & de Jesus, J. D. (2011) · Pediatrics · doi:10.1542/peds.2009-2107c · Cited by 2,131
Ishibashi, S., Brown, M. S., Goldstein, J. L., Gerard, R. D., Hammer, R. E., & Herz, J. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116663 · Cited by 1,354
McGill, H. C., McMahan, C. A., Zieske, A. W., Sloop, G. D., Walcott, J. V., Troxclair, D. A., Malcom, G. T., Tracy, R. E., Oalmann, M. C., & Strong, J. P. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.8.1998 · Cited by 421
Child–Parent Familial Hypercholesterolemia Screening in Primary Care
Wald, D. S., Bestwick, J. P., Morris, J. K., Whyte, K., Jenkins, L., & Wald, N. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1602777 · Cited by 320
Statins for children with familial hypercholesterolemia
Vuorio, A. F., Kuoppala, J., Kovanen, P. T., Humphries, S. E., Tonstad, S., Wiegman, A., Drogari, E., & Ramaswami, U. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006401.pub4 · Cited by 264
Distribution of Lipoproteins by Age and Gender in Adolescents
Jolliffe, C. J., & Janssen, I. (2006) · Circulation · doi:10.1161/circulationaha.106.620864 · Cited by 211
Screening for Lipid Disorders in Children and Adolescents
US Preventive Services Task Force, Bibbins-Domingo, K. B., Grossman, D. C., Curry, S. J., Davidson, K. W., Epling, J. W., García, F., Gillman, M. W., Kemper, A. R., Krist, A. H., et al. (2016) · JAMA · doi:10.1001/jama.2016.9852 · Cited by 174
THE FAMILIAL CHYLOMICRONEMIA SYNDROME
Santamarina-Fojo, S. (1998) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(05)70025-6 · Cited by 162
Guidance for Pediatric Familial Hypercholesterolemia 2017
Harada‐Shiba, M., Ohta, T., Ohtake, A., Ogura, M., Dobashi, K., Nohara, A., Yamashita, S., Yokote, K., & Joint Working Group by Japan Pediatric Society and Japan Atherosclerosis Society for Making Guidance of Pediatric Familial Hypercholesterolemia (2018) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.cr002 · Cited by 90
Primary hypertriglyceridemia in children and adolescents
SHAH, A. S., & Wilson, D. P. (2015) · Journal of clinical lipidology · doi:10.1016/j.jacl.2015.04.004 · Cited by 89
Marais, A. D., Solomon, G. A. E., & Blom, D. J. (2014) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408363.2013.870526 · Cited by 70
Approach to Hypertriglyceridemia in the Pediatric Population
Valaiyapathi, B., Sunil, B., & Ashraf, A. P. (2017) · Pediatrics in Review · doi:10.1542/pir.2016-0138 · Cited by 68
Zappalla, F. R., & Gidding, S. S. (2009) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2008.11.006 · Cited by 37
Secondary hypertriglyceridemia in children and adolescents
Blackett, P. R., Wilson, D. P., & McNeal, C. J. (2015) · Journal of clinical lipidology · doi:10.1016/j.jacl.2015.04.006 · Cited by 35
Universal Cholesterol Screening in Childhood: A Systematic Review
Smith, A. J. B., Turner, E. L., & Kinra, S. (2016) · Academic Pediatrics · doi:10.1016/j.acap.2016.06.005 · Cited by 35
Treatment of dyslipidemia in children and adolescents
Holmes, K. W., & Kwiterovich, P. O. (2005) · Current Cardiology Reports · doi:10.1007/s11886-005-0063-x · Cited by 33
Biochemistry; Lippincott's illustrated reviews
(1988) · International Journal of Biochemistry · doi:10.1016/s0020-711x(98)90024-6 · Cited by 26
Harada‐Shiba, M., Kastelein, J. J. P., Hovingh, G. K., Ray, K. K., Ohtake, A., Arisaka, O., Ohta, T., Okada, T., Suganami, H., & Wiegman, A. (2017) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.42242 · Cited by 25
The safety of statins in children
Lamaida, N., Capuano, E., Pinto, L., Capuano, E., Capuano, R., & Capuano, V. (2013) · Acta Paediatrica · doi:10.1111/apa.12280 · Cited by 24
Genetic disorders of lipoprotein transport in children
Clauss, S. B., & Kwiterovich, P. O. (2003) · Progress in Pediatric Cardiology · doi:10.1016/s1058-9813(03)00049-3 · Cited by 21
What Should Be the Screening Strategy for Familial Hypercholesterolemia?
McCrindle, B. W., & Gidding, S. S. (2016) · New England Journal of Medicine · doi:10.1056/nejme1611081 · Cited by 20
Hyperlipidaemia in Paediatric Patients
Wierzbicki, A. S., & Viljoen, A. (2010) · Drug Safety · doi:10.2165/11319490-000000000-00000 · Cited by 19
Hospital Management of Severe Hypertriglyceridemia in Children
Valaiyapathi, B., & Ashraf, A. P. (2018) · Current Pediatric Reviews · doi:10.2174/1573400514666180117092707 · Cited by 18
Management of hyperlipidemia in pediatrics
Daniels, S. R. (2012) · Current Opinion in Cardiology · doi:10.1097/hco.0b013e32834fea6c · Cited by 17
Management of hyperlipidemia in the pediatric population
Tonstad, S., & Thompson, G. R. (2004) · Current Treatment Options in Cardiovascular Medicine · doi:10.1007/s11936-004-0027-2 · Cited by 14
Statins in the Management of Pediatric Dyslipidemia
Ross, J. L. (2016) · Journal of Pediatric Nursing · doi:10.1016/j.pedn.2016.07.004 · Cited by 14
Why Cholesterol Testing in Children and Adolescents Matters
Gidding, S. S. (2016) · JAMA Cardiology · doi:10.1001/jamacardio.2016.2871 · Cited by 12
Stempel, H., Dodge, A., Marriott, E., & Peterson, A. L. H. (2016) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2016.08.016 · Cited by 12
Management of familial hypercholesterolaemia in children and adolescents
Justo, R. N. (2011) · Journal of Paediatrics and Child Health · doi:10.1111/j.1440-1754.2011.02206.x · Cited by 11
Update on pediatric hyperlipidemia
Chauhan, A., & Paunikar, P. (2014) · Current Opinion in Pediatrics · doi:10.1097/mop.0000000000000078 · Cited by 11
Type V hypertriglyceridemia in children, a therapeutic challenge in pediatrics
Mărginean, C. O., Meliţ, L. E., Dobreanu, M., & Săsăran, M. O. (2017) · Medicine · doi:10.1097/md.0000000000008864 · Cited by 10
A 10-year experience using combined lipid-lowering pharmacotherapy in children and adolescents
Araujo, M. B., & Pacce, M. S. (2016) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem-2016-0117 · Cited by 9
Treatment Strategies for Hypercholesterolemia
Hartz, J., & Clauss, S. B. (2018) · Current Pediatric Reviews · doi:10.2174/1573396314666180111143900 · Cited by 6
Newman, T. B., Schroeder, A. R., & Pletcher, M. J. (2016) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2016.5114 · Cited by 5
Kosmeri, C., Siomou, E. C., Vlahos, A. P., & Milionis, H. J. (2018) · Acta Paediatrica · doi:10.1111/apa.14529 · Cited by 5
Hyperlipidemia treatment in children: the younger, the better.
Gauer, R. L. (2010) · PubMed · Cited by 4
Cholesterol screening for kids sparks debate (again)
Couzin-Frankel, J. (2016) · Science · doi:10.1126/science.353.6302.855 · Cited by 1
Screening children at immunisation visits can identify familial hypercholesterolaemia
Mayor, S. (2016) · BMJ · doi:10.1136/bmj.i5794 · Cited by 1
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Drożdż, D., Pitti, J. Á., Wójcik, M., Borghi, C., Gabbianelli, R., Mazur, A., Herceg-Čavrak, V., López‐Valcárcel, B. G., Brzeziński, M., Lurbe, E., et al. (2021) · Nutrients · doi:10.3390/nu13114176 · Cited by 441
Qiu, Y.-Y., Zhang, J., Zeng, F.-Y., & Zhu, Y. Z. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106786 · Cited by 271
Wang, W., Tan, J., Nima, L., Sang, Y., Cai, X. D., & Xue, H. (2022) · Food Chemistry X · doi:10.1016/j.fochx.2022.100414 · Cited by 161
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Huang, Y., Sulek, K., Stinson, S. E., Holm, L. A., Kim, M. G., Trôst, K., Hooshmand, K., Lund, M. A. V., Fonvig, C. E., Juel, H. B., et al. (2024) · Nature Medicine · doi:10.1038/s41591-024-03279-x · Cited by 79
Metadata
- Authors
- Stewart, J., McCallin, T., Martinez, J., Chacko, S., & Yusuf, S.
- Affiliations
- Baylor College of Medicine (US)
- Venue
- Pediatrics in Review
- Publisher
- American Academy of Pediatrics (AAP)
- Published
- 2020-08-01
- Volume
- 41
- Issue
- 8
- Pages
- 393-402
- ISSN
- 0191-9601 (ISSN-L)
- 1526-3347
- OpenAlex
- W4232459612
- Cited by
- 239
- References
- 40
- Citations by year
- 2026: 28 · 2025: 56 · 2024: 67 · 2023: 37 · 2022: 38 · 2021: 12
- FWCI
- 4.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pediatrics in Review (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Keywords
- hyperlipidemia, childhood obesity, familial hyperlipidemia, cardiovascular disease, atherosclerosis, cholesterol screening, statin therapy, diabetes mellitus, kidney disease, prognosis, prevention
- MeSH terms
- Adolescent, Child, Combined Modality Therapy, Humans, Hyperlipidemias, Pediatrics, Risk Factors, United States
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