The DOI matches its Crossref record; 38 of the 40 references it cites were found in a registry or an index.
Hyperlipidemia
Abstract
Cardiovascular disease remains the top cause of morbidity and mortality in the United States. Atherosclerotic plaques are known to start in adolescence, and, therefore, young adults can be affected by coronary artery disease. Children with known risk factors, such as genetic predisposition, including familial hyperlipidemias, diabetes, and renal diseases, are at higher risk. With childhood obesity becoming an epidemic in certain parts of the United States, this problem is further highlighted as an important issue affecting children's health. There are unclear recommendations for pediatricians regarding cholesterol screening of pediatric populations, when to initiate hyperlipidemia treatment with statin therapy, and when to refer to a specialist for further management. This article reviews the epidemiology and pathophysiology of hyperlipidemia, recommendations for screening and types of screening, management (including pharmacology), prognosis, and prevention.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Hyperlipidemia constitutes a significant risk factor in the onset of cardiovascular diseases (Stewart et al., 2020).”
From Lactiplantibacillus plantarum N4 ameliorates lipid metabolism and gut microbiota structure in high fat diet-fed rats (2024) · cites this paper as Stewart et al., 2020
Citations
Cites
Kavey, R., Simons-Morton, D., & de Jesus, J. D. (2011) · Pediatrics · doi:10.1542/peds.2009-2107c · Cited by 2,131
Ishibashi, S., Brown, M. S., Goldstein, J. L., Gerard, R. D., Hammer, R. E., & Herz, J. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116663 · Cited by 1,354
McGill, H. C., McMahan, C. A., Zieske, A. W., Sloop, G. D., Walcott, J. V., Troxclair, D. A., Malcom, G. T., Tracy, R. E., Oalmann, M. C., & Strong, J. P. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.8.1998 · Cited by 421
Child–Parent Familial Hypercholesterolemia Screening in Primary Care
Wald, D. S., Bestwick, J. P., Morris, J. K., Whyte, K., Jenkins, L., & Wald, N. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1602777 · Cited by 320
Statins for children with familial hypercholesterolemia
Vuorio, A. F., Kuoppala, J., Kovanen, P. T., Humphries, S. E., Tonstad, S., Wiegman, A., Drogari, E., & Ramaswami, U. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006401.pub4 · Cited by 264
Distribution of Lipoproteins by Age and Gender in Adolescents
Jolliffe, C. J., & Janssen, I. (2006) · Circulation · doi:10.1161/circulationaha.106.620864 · Cited by 211
Screening for Lipid Disorders in Children and Adolescents
US Preventive Services Task Force, Bibbins-Domingo, K. B., Grossman, D. C., Curry, S. J., Davidson, K. W., Epling, J. W., García, F., Gillman, M. W., Kemper, A. R., Krist, A. H., et al. (2016) · JAMA · doi:10.1001/jama.2016.9852 · Cited by 174
THE FAMILIAL CHYLOMICRONEMIA SYNDROME
Santamarina-Fojo, S. (1998) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(05)70025-6 · Cited by 162
Guidance for Pediatric Familial Hypercholesterolemia 2017
Harada‐Shiba, M., Ohta, T., Ohtake, A., Ogura, M., Dobashi, K., Nohara, A., Yamashita, S., Yokote, K., & Joint Working Group by Japan Pediatric Society and Japan Atherosclerosis Society for Making Guidance of Pediatric Familial Hypercholesterolemia (2018) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.cr002 · Cited by 90
Primary hypertriglyceridemia in children and adolescents
SHAH, A. S., & Wilson, D. P. (2015) · Journal of clinical lipidology · doi:10.1016/j.jacl.2015.04.004 · Cited by 89
Cited by
Sorted by citations
Obesity and Cardiometabolic Risk Factors: From Childhood to Adulthood
Drożdż, D., Pitti, J. Á., Wójcik, M., Borghi, C., Gabbianelli, R., Mazur, A., Herceg-Čavrak, V., López‐Valcárcel, B. G., Brzeziński, M., Lurbe, E., et al. (2021) · Nutrients · doi:10.3390/nu13114176 · Cited by 441
Qiu, Y.-Y., Zhang, J., Zeng, F.-Y., & Zhu, Y. Z. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106786 · Cited by 271
Wang, W., Tan, J., Nima, L., Sang, Y., Cai, X. D., & Xue, H. (2022) · Food Chemistry X · doi:10.1016/j.fochx.2022.100414 · Cited by 161
Iron, ferroptosis, and ischemic stroke
Guo, J., Tuo, Q., & Lei, P. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15807 · Cited by 163
Huang, Y., Sulek, K., Stinson, S. E., Holm, L. A., Kim, M. G., Trôst, K., Hooshmand, K., Lund, M. A. V., Fonvig, C. E., Juel, H. B., et al. (2024) · Nature Medicine · doi:10.1038/s41591-024-03279-x · Cited by 79
Metadata
- Authors
- Stewart, J., McCallin, T., Martinez, J., Chacko, S., & Yusuf, S.
- Affiliations
- Baylor College of Medicine (US)
- Venue
- Pediatrics in Review
- Publisher
- American Academy of Pediatrics (AAP)
- Published
- 2020-08-01
- Volume
- 41
- Issue
- 8
- Pages
- 393-402
- ISSN
- 0191-9601 (ISSN-L)
- 1526-3347
- OpenAlex
- W4232459612
- Cited by
- 239
- References
- 40
- Citations by year
- 2026: 28 · 2025: 56 · 2024: 67 · 2023: 37 · 2022: 38 · 2021: 12
- FWCI
- 4.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pediatrics in Review (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Keywords
- hyperlipidemia, childhood obesity, familial hyperlipidemia, cardiovascular disease, atherosclerosis, cholesterol screening, statin therapy, diabetes mellitus, kidney disease, prognosis, prevention
- MeSH terms
- Adolescent, Child, Combined Modality Therapy, Humans, Hyperlipidemias, Pediatrics, Risk Factors, United States
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
