The DOI matches its Crossref record; 74 of the 74 references it cites were found in a registry or an index.
An Overview of Carcinogenic Heavy Metal: Molecular Toxicity Mechanism and Prevention
Open accessAbstract
Almost all heavy metals are serious toxicants as carcinogens. However, due to their chemical and physiological properties, heavy metals are useful in industrial areas including alloy, smelting and production of commercial products. Such applications increase the opportunity for heavy metal exposure. Waste from industrial processes is also a major source of environmental contamination and accumulation in the human body. Arsenic, cadmium, chromium, and nickel are classified as group 1 carcinogens by the International Agency for Research on Cancer, and are utilized commercially. In this review, we used molecular pathway analysis to understand the toxicity and carcinogenic mechanisms of these metals. Our analyzed data showed that above-mentioned metallic substances induce oxidative stress, DNA damage, and cell death processes, resulting in increase the risk of cancer and cancer-related diseases. Thus, we might think phytochelatin molecules and antioxidative phytochemical substances are helpful for prevention of heavy metal-induced cancer.
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Cites
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Compendium of chemical terminology
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P HYTOCHELATINS AND M ETALLOTHIONEINS : Roles in Heavy Metal Detoxification and Homeostasis
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Toxic Metals and Oxidative Stress Part I: Mechanisms Involved in Me-tal induced Oxidative Damage
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Cited by
Toxic Mechanisms of Five Heavy Metals: Mercury, Lead, Chromium, Cadmium, and Arsenic
Balali-Mood, M., Naseri, K., Tahergorabi, Z., Khazdair, M. R., & Sadeghi, M. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.643972 · Cited by 3,121
Witkowska, D., Słowik, J., & Chilicka, K. (2021) · Molecules · doi:10.3390/molecules26196060 · Cited by 593
Environmental pollutants and their effects on human health
Shetty, S. S., D, D., S, H., Sonkusare, S., Naik, P. B., Kumari N, S., & Madhyastha, H. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e19496 · Cited by 521
Heavy Metal Contamination of Natural Foods Is a Serious Health Issue: A Review
Munir, N., Jahangeer, M., Bouyahya, A., El Omari, N., Ghchime, R., Balahbib, A., Aboulaghras, S., Mahmood, Z., Akram, M., Ali Shah, S. M., et al. (2021) · Sustainability · doi:10.3390/su14010161 · Cited by 322
Parvin, F., & Tareq, S. M. (2021) · Applied Water Science · doi:10.1007/s13201-021-01431-3 · Cited by 299
Metadata
- Authors
- Kim, H. S., Kim, Y. J., & Seo, Y. R.
- Venue
- Journal of Cancer Prevention
- Publisher
- Korean Society of Cancer Prevention
- Published
- 2015-12-30
- Volume
- 20
- Issue
- 4
- Pages
- 232-240
- ISSN
- 2288-3649 (ISSN-L)
- 2288-3657
- OpenAlex
- W2317238873
- Cited by
- 684
- References
- 74
- FWCI
- 13.22
- Type
- journal article
- Language
- en
- Open access
- diamond
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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