The DOI matches its Crossref record; 110 of the 110 references it cites were found in a registry or an index.
Heavy Metals and Human Health: Possible Exposure Pathways and the Competition for Protein Binding Sites
Open accessAbstract
Heavy metals enter the human body through the gastrointestinal tract, skin, or via inhalation. Toxic metals have proven to be a major threat to human health, mostly because of their ability to cause membrane and DNA damage, and to perturb protein function and enzyme activity. These metals disturb native proteins’ functions by binding to free thiols or other functional groups, catalyzing the oxidation of amino acid side chains, perturbing protein folding, and/or displacing essential metal ions in enzymes. The review shows the physiological and biochemical effects of selected toxic metals interactions with proteins and enzymes. As environmental contamination by heavy metals is one of the most significant global problems, some detoxification strategies are also mentioned.
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Cites
Mercury 4.0: from visualization to analysis, design and prediction
Macrae, C. F., Sovago, I., Cottrell, S. J., Galek, P. T. A., McCabe, P., Pidcock, E., Platings, M., Shields, G. P., Stevens, J. S., Towler, M., et al. (2020) · Journal of Applied Crystallography · doi:10.1107/s1600576719014092 · Cited by 5,091
Heavy Metal Pollution in the Environment and Their Toxicological Effects on Humans
Briffa, J., Sinagra, E., & Blundell, R. (2020) · Heliyon · doi:10.1016/j.heliyon.2020.e04691 · Cited by 4,402
Toxic Mechanisms of Five Heavy Metals: Mercury, Lead, Chromium, Cadmium, and Arsenic
Balali-Mood, M., Naseri, K., Tahergorabi, Z., Khazdair, M. R., & Sadeghi, M. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.643972 · Cited by 3,121
Heavy metals in food crops: health risks, fate, mechanisms, and management
Rai, P. K., Lee, S. S., Zhang, M., Tsang, Y. F., & Kim, K.-H. (2019) · Environment International · doi:10.1016/j.envint.2019.01.067 · Cited by 1,895
Naujokas, M. F., Anderson, B., Ahsan, H., Aposhian, H. V., Graziano, J. H., Thompson, C., & Suk, W. A. (2013) · Environmental Health Perspectives · doi:10.1289/ehp.1205875 · Cited by 1,372
Jan, A., Azam, M., Siddiqui, K., Ali, A., Choi, I., & Haq, Q. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161226183 · Cited by 1,225
Metal ions in biological catalysis: from enzyme databases to general principles
Andreini, C., Bertini, I., Cavallaro, G., Holliday, G. L., & Thornton, J. M. (2008) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-008-0404-5 · Cited by 1,150
Chromium in Drinking Water: Sources, Metabolism, and Cancer Risks
Zhitkovich, A. (2011) · Chemical Research in Toxicology · doi:10.1021/tx200251t · Cited by 1,132
Shen, S., Li, X.-F., Cullen, W. R., Weinfeld, M., & Le, X. C. (2013) · Chemical Reviews · doi:10.1021/cr300015c · Cited by 818
Human Exposure and Health Effects of Inorganic and Elemental Mercury
Park, J.-D., & Zheng, W. (2012) · Journal of Preventive Medicine & Public Health · doi:10.3961/jpmph.2012.45.6.344 · Cited by 770
Cited by
Analysis of Heavy Metal Impacts on Cereal Crop Growth and Development in Contaminated Soils
Vasilachi, I. C., Stoleru, V., & Gavrilescu, M. (2023) · Agriculture · doi:10.3390/agriculture13101983 · Cited by 210
Metadata
- Authors
- Witkowska, D., Słowik, J., & Chilicka, K.
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2021-10-07
- Volume
- 26
- Issue
- 19
- Pages
- 6060
- ISSN
- 1420-3049 (ISSN-L)
- OpenAlex
- W3203389248
- Cited by
- 593
- References
- 110
- FWCI
- 26.40
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
