Human Papillomavirus Prevalence and Type Distribution Among 968 Women in South Korea.
Open accessAbstract
BACKGROUND: Geographic variation in the prevalence of carcinogenic types and human papillomavirus (HPV) genotype distribution is closely associated with the impact of HPV prophylactic vaccines. We determined the prevalence and distribution of HPV genotypes among healthy women in Korea. METHODS: This study included 968 healthy women who were examined at a health promotion center of the Korea University Guro Hospital between January and June 2013. Each participant had a Pap test and a HPV DNA test using the Anyplex™ II HPV 28 Detection system, which detects 19 high-risk HPVs (HR HPVs) and 9 low-risk HPVs (LR HPVs). Women with abnormal cytology and/or positivity for HR HPVs were referred to colposcopic biopsy. RESULTS: Overall HR HPV prevalence based on the assay was 33.7%. Among them, 225 women had single infection and 101 women had multiple infection. The most frequently occurring HR HPV types were 53 (6.5%), 52 (6.1%), 58 (4.8%), 16 (4.5%), and 68 (4.2%). The most frequently occurring LR HPV types were 54 (5.4%), 70 (3.8%), 42 (3.6%), 61 (3.4%), and 44 (3.1%). The prevalence of HPV 16 was highest (17.6%) among women with cervical intraepithelial neoplasia (CIN) and HPV 16 was strongly associated with a diagnosis of CIN2/3 (odds ratio = 20.5; 95% confidence interval: 3.9-107.1; P < 0.0001). CONCLUSIONS: HPV 53, 52, 58, 16, and 68 were common HR HPV types among healthy Korean women. HPV16 was the most common type in high-grade CIN lesions, as shown in most studies worldwide. The results might be useful information for cervical cancer prevention in South Korea.
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Anyplex is widely used for cervical cancer screening in South Korea, including at the authors' hospital.
“Anyplex is also widely used for cervical cancer screening in South Korea, including at our hospital [30–32].”
From Comparison of Seegene Anyplex II HPV28 assay with BD Onclarity HPV assay for human papillomavirus genotyping (2022) · cites this paper as [30]
The Materials and Methods (Study population; Human papillomavirus DNA testing, pages not provided) document use of Anyplex for HPV testing at Korea University Guro Hospital. The paper does not establish that Anyplex is widely used for cervical cancer screening across South Korea or that it is used at the citing authors’ hospital. (LLM, conf=0.87)
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Zhao, F.-H., Lin, M. J., Chen, F., Hu, S.-Y., Zhang, R., Belinson, J. L., Sellors, J. W., Franceschi, S., Qiao, Y.-L., & Castle, P. E. (2010) · The Lancet Oncology · doi:10.1016/s1470-2045(10)70256-4 · Cited by 158 · see citing works
Comparison of Seegene Anyplex II HPV28 with the PGMY-CHUV Assay for Human Papillomavirus Genotyping
Estrade, C., & Sahli, R. (2014) · Journal of Clinical Microbiology · doi:10.1128/jcm.02749-13 · Cited by 57 · cited 1× · see citing works
“The Anyplex II HPV28 assay is a very sensitive and specific HPV genotyping assay.(14) It is more sensitive in the detection of HR types represented by Hybrid Capture 2 assay and exhibits a higher concordance with comprehensive genotyping based on the sequencing analysis.”
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Research works printed but not linked: 21
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Kim, M., Kim, J., Park, N. J.-Y., & Park, J. Y. (2022) · PLOS ONE · doi:10.1371/journal.pone.0267836 · Cited by 5 · see citing works
- Authors
- So, K. A., Hong, J. H., & Lee, J. K.
- Affiliations
- Cheil General Hospital and Women's Healthcare Center (KR)
- Korea University Guro Hospital (KR)
- Corresponding author
- Lee, Jae Kwan
- Venue
- Journal of Cancer Prevention
- Publisher
- Korean Society of Cancer Prevention
- Published
- 2016-06-30
- Volume
- 21
- Issue
- 2
- Pages
- 104-109
- ISSN
- 2288-3649 (ISSN-L)
- 2288-3657
- PMC
- PMC4933434
- OpenAlex
- W2470088360
- Cited by
- 37
- References
- 2
- Citations by year
- 2026: 6 · 2023: 2 · 2022: 4 · 2021: 4 · 2020: 6 · 2019: 3 · 2018: 6 · 2017: 5 · 2016: 1
- FWCI
- 4.69
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc
- Locations
- Journal of Cancer Prevention (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Women's cancer prevention and management
- Keywords
- human papillomavirus, HPV prevalence, HPV genotype distribution, high-risk HPV, low-risk HPV, HPV16, HPV53, HPV52, HPV58, HPV68, cervical intraepithelial neoplasia, multiple HPV infection, healthy women, cervical cancer prevention, South Korea
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