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Cited by 245Gestational Diabetes Research and ManagementDiabetes Management and ResearchPregnancy and Medication Impact

Gestational diabetes mellitus

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Alfadhli, Eman M.·2015·Saudi Medical Journal
DOI 10.15537/smj.2015.4.10307PMC PMC4404472
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Abstract

Gestational diabetes mellitus (GDM) is the most common medical complication of pregnancy. It is associated with maternal and neonatal adverse outcomes. Maintaining adequate blood glucose levels in GDM reduces morbidity for both mother and baby. There is a lack of uniform strategies for screening and diagnosing GDM globally. This review covers the latest update in the diagnosis and management of GDM. The initial treatment of GDM consists of diet and exercise. If these measures fail to achieve glycemic goals, insulin should be initiated. Insulin analogs are more physiological than human insulin, and are associated with less risk of hypoglycemia, and may provide better glycemic control. Insulin lispro, aspart, and detemir are approved to be used in pregnancy. Insulin glargine is not approved in pregnancy, but the existing studies did not show any contraindications. The use of oral hypoglycemic agents; glyburide and metformin seems to be safe and effective in pregnancy.

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Cited by

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Authors
Alfadhli, E. M.
Affiliations
Taibah University (SA)
Corresponding author
Alfadhli, Eman M.
ORCID
Alfadhli, Eman M.
Venue
Saudi Medical Journal
Publisher
Armed Forces Medical Services
Published
2015
Volume
36
Issue
4
Pages
399-406
ISSN
  • 0379-5284 (ISSN-L)
  • 1658-3175
DOI
10.15537/smj.2015.4.10307
PMC
PMC4404472
OpenAlex
W1963613891
Cited by
245
References
12
Citations by year
2026: 14 · 2025: 33 · 2024: 27 · 2023: 41 · 2022: 38 · 2021: 31 · 2020: 31 · 2019: 14 · 2018: 5 · 2017: 6 · 2016: 4 · 2015: 1
FWCI
0.79
Type
journal article
Language
en
Open access
Licence
cc-by-nc-sa
Locations
  • Saudi Medical Journal (publishedVersion, cc-by-nc-sa)
  • PubMed Central (publishedVersion, cc-by-nc-sa)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
Keywords
gestational diabetes mellitus, GDM diagnosis, GDM screening, glycemic control, insulin therapy, insulin analogues, insulin lispro, insulin aspart, insulin detemir, insulin glargine, diet and exercise, oral antidiabetic drugs, metformin, glibenclamide, hypoglycemia, maternal and neonatal outcomes
MeSH terms
Diet, Exercise Therapy, Female, Humans, Hypoglycemic Agents, Pregnancy, Risk Factors, Diabetes, Gestational

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