Comorbidities and severity of coronavirus disease 2019 patients
Open accessAbstract
OBJECTIVES: To determine the association between comorbidities and the severity of the disease among COVID-19 patients. METHODS: We searched the Cochrane, Medline, Trip, and EMBASE databases from 2019. The review included all available studies of COVID-19 patients published in the English language and studied the clinical characteristics, comorbidities, and disease outcomes from the beginning of the pandemic. Two authors extracted studies characteristics and the risk of bias. Odds ratio (OR) was used to analyze the data with 95% confidence interval (CI). RESULTS: The review included 1,885 COVID-19 patients from 7 observational studies with some degree of bias risk and substantial heterogeneity. A significant association was recorded between COVID-19 severity and the following variables: male (OR= 1.60, 95%CI= 1.05 - 2.43); current smoker (OR=2.06, 95%CI= 1.08 - 3.94); and the presence of comorbidities including hypertension (OR=2.05, 95%CI= 1.56 - 2.70), diabetes (OR=2.46, 95%CI= 1.53 - 3.96), coronary heart disease (OR=4.10, 95%CI= 2.36 - 7.12), chronic kidney disease (OR=4.06, 95%CI= 1.45 - 11.35), and cancer (OR=2.28, 95%CI= 1.08 - 4.81). CONCLUSIONS: Comorbidities among COVID-19 patients may contribute to increasing their susceptibility to severe illness. The identification of these potential risk factors could help reduce mortality by identifying patients with poor prognosis at an early stage.
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GRADE: an emerging consensus on rating quality of evidence and strength of recommendations
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Vocational School of Health Services, D. E. U., Acikgoz, A., Yoruk, S., School of Health, D. O. M., Toyran, N., Vocational School of Health Services, D. E. U., Guler, D. S., & Training And Research Hospital, S. U. (2023) · Psychiatria Danubina · doi:10.24869/psyd.2023.544
“In a recent systematic review, smokers were shown to be twice as likely to have severe COVID-19-related ill - ness as nonsmokers (Radwan et al. 2019).”
- Authors
- Radwan, N. M., Mahmoud, N. E., Alfaifi, A. H., & Alabdulkareem, K. I.
- Affiliations
- Tanta University (EG)
- Corresponding author
- Radwan, Nashwa M.
- Venue
- Saudi Medical Journal
- Publisher
- Armed Forces Medical Services
- Published
- 2020-11
- Volume
- 41
- Issue
- 11
- Pages
- 1165-1174
- ISSN
- 0379-5284 (ISSN-L)
- 1658-3175
- PMC
- PMC7804237
- OpenAlex
- W3096260704
- Cited by
- 27
- References
- 3
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 8 · 2022: 2 · 2021: 12
- FWCI
- 0.72
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- Saudi Medical Journal (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Neurology › Long-Term Effects of COVID-19
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Keywords
- COVID-19 pandemic, comorbidities, disease severity, risk factors, hypertension, diabetes mellitus, coronary artery disease, chronic kidney disease, cancer, smoking, male sex, prognosis
- MeSH terms
- Data Management, COVID-19, Cause of Death, Disease Susceptibility, Female, Humans, Male, Pneumonia, Viral, Saudi Arabia, Severity of Illness Index, Comorbidity, Incidence, Survival Analysis, Coronavirus Infections, Severe Acute Respiratory Syndrome, Pandemics
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