Clinical Features and Treatment of COVID-19 Patients in Northeast Chongqing
Open accessAbstract
The outbreak of the novel coronavirus in China (SARS-CoV-2) that began in December 2019 presents a significant and urgent threat to global health. This study was conducted to provide the international community with a deeper understanding of this new infectious disease. Epidemiological, clinical features, laboratory findings, radiological characteristics, treatment, and clinical outcomes of 135 patients in northeast Chongqing were collected and analyzed in this study. A total of 135 hospitalized patients with COVID-19 were enrolled. The median age was 47 years (interquartile range, 36-55), and there was no significant gender difference (53.3% men). The majority of patients had contact with people from the Wuhan area. Forty-three (31.9%) patients had underlying disease, primarily hypertension (13 [9.6%]), diabetes (12 [8.9%]), cardiovascular disease (7 [5.2%]), and malignancy (4 [3.0%]). Common symptoms included fever (120 [88.9%]), cough (102 [76.5%]), and fatigue (44 [32.5%]). Chest computed tomography scans showed bilateral patchy shadows or ground glass opacity in the lungs of all the patients. All patients received antiviral therapy (135 [100%]) (Kaletra and interferon were both used), antibacterial therapy (59 [43.7%]), and corticosteroids (36 [26.7%]). In addition, many patients received traditional Chinese medicine (TCM) (124 [91.8%]). It is suggested that patients should receive Kaletra early and should be treated by a combination of Western and Chinese medicines. Compared to the mild cases, the severe ones had lower lymphocyte counts and higher plasma levels of Pt, APTT, d-dimer, lactate dehydrogenase, PCT, ALB, C-reactive protein, and aspartate aminotransferase. This study demonstrates the clinic features and therapies of 135 COVID-19 patients. Kaletra and TCM played an important role in the treatment of the viral pneumonia. Further studies are required to explore the role of Kaletra and TCM in the treatment of COVID-19.
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Inflammatory serological markers usually associated with bacterial infection may appear in patients with COVID-19 without a corresponding bacterial co-infection.
“there is evidence that the inflammatory serological markers that are usually associated with bacterial infection, such as raised procalcitonin and C-reactive protein, may appear in patients with COVID-19 without a corresponding bacterial co-infection occurring.12 , 13”
From Co-infections in people with COVID-19: a systematic review and meta-analysis. (2020) · cites this paper as [12]
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Impact of Corticosteroids in Coronavirus Disease 2019 Outcomes
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The Effect of Smoking on COVID-19 Symptom Severity: Systematic Review and Meta-Analysis
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- Authors
- Wan, S., Xiang, Y., Fang, W., Zheng, Y., Li, B., Hu, Y., Lang, C., Huang, D., Sun, Q., Xiong, Y., Huang, X., Lv, J., Luo, Y., Shen, L., Yang, H., Huang, G., & Yang, R.
- Affiliations
- Chongqing University (CN)
- Chongqing Medical University (CN)
- Pharmaceutical Department of Chongqing Three Gorges Central Hospital Chongqing University Three Gorges Hospital Chongqing China
- Corresponding author
- Zheng, Yu
- Li, Boqun
- Hu, Yanjun
- ORCID
- Venue
- Journal of Medical Virology
- Publisher
- Wiley
- Published
- 2020-04
- Volume
- 92
- Issue
- 7
- Pages
- 797-806
- ISSN
- 0146-6615 (ISSN-L)
- 1096-9071
- PMC
- PMC7228368
- OpenAlex
- W3012673820
- Cited by
- 982
- References
- 27
- Citations by year
- 2026: 2 · 2025: 13 · 2024: 40 · 2023: 75 · 2022: 125 · 2021: 299 · 2020: 427 · 2012: 1
- FWCI
- 30.44
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Medical Virology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fundamental Research Funds for the Central Universities (2020CDJYGRH-YJ03)
- National Social Science Foundation (15BGL191)
- Topics
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Neurology › Long-Term Effects of COVID-19
- Keywords
- COVID-19 pandemic, SARS-CoV-2, clinical features, lopinavir/ritonavir, ritonavir, traditional Chinese medicine, antiviral therapy, corticosteroids, antibiotic therapy, interferon, viral pneumonia, chest CT findings, ground-glass opacities, lymphocyte count, D-dimer, lactate dehydrogenase, C-reactive protein, comorbidities, hospitalized patients
- MeSH terms
- Betacoronavirus, COVID-19, SARS-CoV-2, COVID-19 Testing, Adolescent, Adrenal Cortex Hormones, Adult, Aged, Anti-Bacterial Agents, Antiviral Agents, Cardiovascular Diseases, China, Cough, Diabetes Mellitus, Drug Combinations, Drugs, Chinese Herbal, Fatigue, Female, Fever, Humans, Interferons, Male, Middle Aged, Neoplasms, Pneumonia, Viral, Retrospective Studies, Severity of Illness Index, Tomography, X-Ray Computed, Biomarkers, Coronavirus Infections, Clinical Laboratory Techniques, Ritonavir, Diabetes Complications, Pandemics, Lopinavir
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