The DOI matches its Crossref record; 82 of the 82 references it cites were found in a registry or an index.
The complement system: History, pathways, cascade and inhibitors
Open accessAbstract
Since its discovery in the 19th century, the complement system has developed into a clinically significant entity. The complement system has been implicated in a variety of clinical conditions, from autoimmune diseases to ischemia-reperfusion injury in transplantation. This article charts the historical progress of our understanding of the complement system and provides a synopsis on the activation pathways and its inherent regulators.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Walport, M. J. (2001) · New England Journal of Medicine · doi:10.1056/nejm200104053441406 · Cited by 2,927
Wiklund, R. A., & Rosenbaum, S. H. (1997) · New England Journal of Medicine · doi:10.1056/nejm199710163371606 · Cited by 2,149
Walport, M. J. (2001) · New England Journal of Medicine · doi:10.1056/nejm200104123441506 · Cited by 1,481
Pillemer, L., Blum, L., Lepow, I. H., Ross, O. A., Todd, E. W., & Wardlaw, A. C. (1954) · Science · doi:10.1126/science.120.3112.279 · Cited by 938
Complement-dependent Clearance of Apoptotic Cells by Human Macrophages
Mevorach, D., Mascarenhas, J. O., Gershov, D., & Elkon, K. B. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.12.2313 · Cited by 700
Davies, A., Simmons, D. L., Hale, G., Harrison, R. A., Tighe, H., Lachmann, P. J., & Waldmann, H. (1989) · The Journal of experimental medicine · doi:10.1084/jem.170.3.637 · Cited by 633
Complement: a unique innate immune sensor for danger signals
GASQUE, P. (2004) · Molecular Immunology · doi:10.1016/j.molimm.2004.06.011 · Cited by 552
Meri, S., Morgan, B. P., Davies, A., Daniels, R. H., Olavesen, M. G., Waldmann, H., & Lachmann, P. J. (1990) · PubMed Central · Cited by 533
Anaphylatoxin inactivator of human plasma: its isolation and characterization as a carboxypeptidase
Bokisch, V. A., & Müller-Eberhard, H. J. (1970) · Journal of Clinical Investigation · doi:10.1172/jci106462 · Cited by 517
Demonstration of specific C5a receptor on intact human polymorphonuclear leukocytes.
Chenoweth, D. E., & Hugli, T. E. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.8.3943 · Cited by 509
Cited by
Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis
Gralinski, L. E., Sheahan, T. P., Morrison, T. E., Menachery, V. D., Jensen, K., Leist, S. R., Whitmore, A., Heise, M. T., & Baric, R. S. (2018) · mBio · doi:10.1128/mbio.01753-18 · Cited by 655
The associations of cerebrospinal fluid ApoE and C1q with Alzheimer's disease biomarkers
Lin, Y.-J., Liu, Y., Sheng, Z.-H., Fu, Y., Ma, L.-Z., Zhang, Z.-H., Wang, L.-Y., Huang, L.-Y., Liu, M., Wang, Z.-T., et al. (2025) · Journal of Alzheimer’s Disease · doi:10.1177/13872877251320419 · Cited by 3
Metadata
- Authors
- Nesargikar, P., Spiller, B., & Chavez, R.
- Venue
- European Journal of Microbiology and Immunology
- Publisher
- Akademiai Kiado Zrt.
- Published
- 2012-06
- Volume
- 2
- Issue
- 2
- Pages
- 103-111
- ISSN
- 2062-509X (ISSN-L)
- 2062-8633
- OpenAlex
- W2077888633
- Cited by
- 324
- References
- 82
- FWCI
- 1.11
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The complement system: History, pathways, cascade and inhibitors. https://app.cochat.ai/papers/10.1556/eujmi.2.2012.2.2
- The paper
- Nesargikar, P., Spiller, B., & Chavez, R. (2012). The complement system: History, pathways, cascade and inhibitors. European Journal of Microbiology and Immunology. https://doi.org/10.1556/eujmi.2.2012.2.2
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.