The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Anaphylatoxin inactivator of human plasma: its isolation and characterization as a carboxypeptidase
Open accessAbstract
The failure of human serum to give rise to anaphylatoxin activity could be attributed to the presence of a potent inactivator of anaphylatoxin in human serum. The inactivator was isolated and characterized as an alpha-globulin with a molecular weight of approximately 310,000. It was found to abolish the activity of both anaphylatoxins, which are derived respectively from the third and the fifth component of complement, and of bradykinin. Inactivation of C3-derived anaphylatoxin and of bradykinin was accompanied by release of C-terminal arginine from these peptides. The anaphylatoxin inactivator was shown to hydrolyze the synthetic substrates hippuryl-L-arginine and hippuryl-L-lysine and to be inhibited by ethylenediaminetetraacetate (EDTA) or phenanthroline. These observations indicate that the anaphylatoxin inactivator constitutes a metal-dependent enzyme resembling in specificity pancreatic carboxypeptidase B.
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Cites
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Hypotensive Peptides: Bradykinin, Kallidin, and Eledoisin
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Cited by
The role of the anaphylatoxins in health and disease
Klos, A., Tenner, A. J., Johswich, K.-O., Ager, R. R., Reis, E. S., & Köhl, J. (2009) · Molecular Immunology · doi:10.1016/j.molimm.2009.04.027 · Cited by 730
Structure and function of the anaphylatoxins
Hugh, T. E. (1984) · Springer Seminars in Immunopathology · doi:10.1007/bf01893020 · Cited by 259
Structure and evolution of the apolipoprotein multigene family
Luo, C.-C., Li, W.-H., Moore, M. N., & Chan, L. (1986) · Journal of Molecular Biology · doi:10.1016/0022-2836(86)90436-5 · Cited by 173
Crosstalk between the renin–angiotensin, complement and kallikrein–kinin systems in inflammation
Bekassy, Z., Lopatko Fagerström, I., Bader, M., & Karpman, D. (2022) · Nature reviews. Immunology · doi:10.1038/s41577-021-00634-8 · Cited by 167
Complement pathway amplifies caspase-11–dependent cell death and endotoxin-induced sepsis severity
Napier, B. A., Brubaker, S. W., Sweeney, T. E., Monette, P., Rothmeier, G. H., Gertsvolf, N. A., Puschnik, A., Carette, J. E., Khatri, P., & Monack, D. M. (2016) · Journal of Experimental Medicine · doi:10.1084/jem.20160027 · Cited by 149
Metadata
- Authors
- Bokisch, V. A., & Müller-Eberhard, H. J.
- Venue
- Journal of Clinical Investigation
- Published
- 1970-12-01
- Volume
- 49
- Issue
- 12
- Pages
- 2427-2436
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W1987577695
- Cited by
- 517
- References
- 8
- FWCI
- 4.49
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bokisch, V. A., & Müller-Eberhard, H. J. (1970). Anaphylatoxin inactivator of human plasma: its isolation and characterization as a carboxypeptidase. Journal of Clinical Investigation. https://doi.org/10.1172/jci106462
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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