Biodegradable Polymer Composites for Temporary Replacement of Trabecular Bone: The Effect of Polymer Molecular Weight on Composite Strength and Modulus
Abstract
Our laboratory has been developing a particulate composite material as a temporary replacement for trabecular bone. The material is degradable in physiologic fluids, and uses starting materials that the body can metabolize and excrete. This study investigates the influence of the molecular weight of one component, a linear polyester, on the mechanical strength of the composite material. The compressive strength and modulus increase from “low” to “medium” molecular weight, but do not increase further from “medium” to “high” molecular weight. Low, medium, and high are relative to the highest molecular weight attainable with the current reaction scheme, which is a number average molecular weight (M n) of 2,038 and a weight average molecular weight (M w) of 11,916.
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Biodegradable synthetic polymers for tissue engineering
CSIRO Molecular Science, B. 1., & Gunatillake, P. (2003) · European Cells and Materials · doi:10.22203/ecm.v005a01 · Cited by 1,765 · see citing works
Yaszemski, M. J., Payne, R. G., Hayes, W. C., Langer, R., Aufdemorte, T. B., & Mikos, A. G. (1995) · Tissue Engineering · doi:10.1089/ten.1995.1.41 · Cited by 149 · see citing works
Self-citationCharacterization of partially saturated poly(propylene fumarate) for orthopaedic application
Peter, S. J., Yaszemski, M. J., Suggs, L. J., Payne, R. G., Langer, R., Hayes, W. C., Unroe, M. R., Alemany, L. B., Engel, P. S., & Mikos, A. G. (1997) · Journal of Biomaterials Science Polymer Edition · doi:10.1163/156856297x00074 · Cited by 84 · see citing works
Self-citationXu, B., Lee, K., Li, W., Yaszemski, M. J., Lu, L., Yang, Y., & Wang, S. (2021) · Materials & Design · doi:10.1016/j.matdes.2021.110150 · Cited by 40 · see citing works
Self-citationSuggs, L. J., Payne, R. G., Kao, E. Y., Alemany, L. B., Yaszemski, M. J., Wu, K. K., & Mikos, A. G. (1995) · MRS Proceedings · doi:10.1557/proc-394-167
Self-citation
- Authors
- Yaszemski, M. J., Mikos, A. G., Payne, R. G., & Hayes, W. C.
- Affiliations
- Harvard University (US)
- Rice University (US)
- Wilford Hall Ambulatory Surgical Center (US)
- Corresponding author
- Yaszemski, Michael J.
- Venue
- MRS Proceedings
- Published
- 1993
- Volume
- 331
- ISSN
- 0272-9172 (ISSN-L)
- 1946-4274
- OpenAlex
- W2334523411
- Cited by
- 5
- References
- 0
- Citations by year
- 2021: 1
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- MRS Proceedings (publishedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Health Sciences › Medicine › Surgery › Orthopaedic implants and arthroplasty
- Keywords
- biodegradable polymer composites, molecular weight effects, linear polyesters, compressive strength, elastic modulus, particle-reinforced composites, mechanical properties
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