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Topical Bioadhesive Patch Systems Enhance Selectivity of Protoporphyrin IX Accumulation
Abstract
In clinical 5‐aminolevulinic acid (ALA)‐based photodynamic therapy (PDT) of skin tumors it is desirable to develop vehicles that minimize the penetration of ALA through normal stratum corneum and maximize it through the compromised stratum corneum of the tumors to improve tumor selectivity. We have designed a bioadhesive patch, which may be able to achieve this aim. It induces levels of protoporphyrin IX (PpIX) in skin overlying tumors similar to those induced by the proprietary cream (Porphin®) but at the same time induces less PpIX to form in normal skin and at distant sites. The mechanisms of action of the patch, as compared with that of the cream, were studied by means of Cuprophan® barriers that mimic compromised tumor stratum corneum and in a mouse model with transplanted tumors.
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Moan's group proposed topical bioadhesive patch systems that enhance selectivity of PpIX accumulation in a tumor-bearing mice model.
“Interestingly, Moan's group proposed topical bioadhesive patch systems that enhance selectivity of PpIX accumulation in tumor-bearing mice model [80].”
From Aminolevulinic Acid (ALA) as a Prodrug in Photodynamic Therapy of Cancer (2011) · cites this paper as [80]
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Metadata
- Authors
- Donnelly, R. F., Ma, L., Juzenas, P., Lani, V., McCarron, P. A., Woolfson, A. D., & Moan, J.
- Affiliations
- Queen's University Belfast (GB)
- Corresponding author
- Donnelly, Ryan F.
- Venue
- Photochemistry and Photobiology
- Publisher
- Wiley
- Published
- 2006-05
- Volume
- 82
- Issue
- 3
- Pages
- 670-675
- ISSN
- 0031-8655 (ISSN-L)
- 1751-1097
- OpenAlex
- W2141594040
- Cited by
- 22
- References
- 28
- Citations by year
- 2025: 1 · 2021: 1 · 2019: 1 · 2018: 1 · 2016: 1 · 2012: 1
- FWCI
- 2.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Photochemistry and Photobiology (publishedVersion)
- PubMed (publishedVersion)
- BioOne Complete (BioOne) (submittedVersion)
- Research Portal (Queen's University Belfast) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Photodynamic Therapy Research Studies
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Health Sciences › Medicine › Dermatology › Nonmelanoma Skin Cancer Studies
- Keywords
- protoporphyrin IX accumulation, 5-aminolevulinic acid, photodynamic therapy, skin tumors, tumor selectivity, stratum corneum, topical drug delivery, transplantable tumors
- MeSH terms
- Administration, Cutaneous, Animals, Disease Models, Animal, Neoplasms, Protoporphyrins, Skin Absorption, Mice
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