The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Computational analysis of gene-gene interactions using multifactor dimensionality reduction
Abstract
Understanding the relationship between DNA sequence variations and biologic traits is expected to improve the diagnosis, prevention and treatment of common human diseases. Success in characterizing genetic architecture will depend on our ability to address nonlinearities in the genotype-to-phenotype mapping relationship as a result of gene-gene interactions, or epistasis. This review addresses the challenges associated with the detection and characterization of epistasis. A novel strategy known as multifactor dimensionality reduction that was specifically designed for the identification of multilocus genetic effects is presented. Several case studies that demonstrate the detection of gene-gene interactions in common diseases such as atrial fibrillation, Type II diabetes and essential hypertension are also discussed.
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Cites
A simulation study of the number of events per variable in logistic regression analysis
Peduzzi, P., Concato, J., Kemper, E., Holford, T. R., & Feinstein, A. R. (1996) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(96)00236-3 · Cited by 9,655
XV.—The Correlation between Relatives on the Supposition of Mendelian Inheritance.
Fisher, R. A. (1919) · Transactions of the Royal Society of Edinburgh · doi:10.1017/s0080456800012163 · Cited by 4,387
A comprehensive review of genetic association studies
Hirschhorn, J. N., Lohmueller, K., Byrne, E., & Hirschhorn, K. (2002) · Genetics in Medicine · doi:10.1097/00125817-200203000-00002 · Cited by 1,674
Cited by
Detecting gene–gene interactions that underlie human diseases
Cordell, H. J. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2579 · Cited by 1,350
Moore, J. H., Gilbert, J. C., Tsai, C.-T., Chiang, F.-T., Holden, T., Barney, N., & White, B. C. (2006) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2005.11.036 · Cited by 608
Self-citationVelez, D. R., White, B. C., Motsinger, A. A., Bush, W. S., Ritchie, M. D., Williams, S. M., & Moore, J. H. (2007) · Genetic Epidemiology · doi:10.1002/gepi.20211 · Cited by 384
Self-citationMoore, J. H., & Williams, S. M. (2005) · BioEssays · doi:10.1002/bies.20236 · Cited by 340
Self-citationMachine Learning for Detecting Gene-Gene Interactions: A Review
McKinney, B. A., Reif, D. M., Ritchie, M. D., & Moore, J. H. (2006) · Applied Bioinformatics · doi:10.2165/00822942-200605020-00002 · Cited by 254
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Metadata
- Authors
- Moore, J. H.
- Venue
- Expert Review of Molecular Diagnostics
- Publisher
- Informa UK Limited
- Published
- 2004-11
- Volume
- 4
- Issue
- 6
- Pages
- 795-803
- ISSN
- 1473-7159 (ISSN-L)
- 1744-8352
- OpenAlex
- W2083413750
- Cited by
- 245
- References
- 3
- FWCI
- 8.92
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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