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Cited by 214Immunotherapy and Immune ResponsesAdvanced Drug Delivery SystemsNanoparticle-Based Drug Delivery

The DOI matches its Crossref record; 155 of the 155 references it cites were found in a registry or an index.

Microparticles as vaccine adjuvants and delivery systems

O’Hagan, Derek T, Singh, Manmohan·2003·Expert Review of Vaccines
DOI 10.1586/14760584.2.2.269
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Abstract

Adjuvants can be broadly divided into two groups, based on their principal mechanisms of action: vaccine delivery systems and immunostimulatory adjuvants. Vaccine delivery systems are generally particulate (e.g., emulsions, microparticles, immunostimulatory complexes and liposomes) and function mainly to target associated antigens into antigen-presenting cells. However, increasingly, more complex formulations are being developed in which delivery systems are exploited both for the delivery of antigens and also for the delivery of coadministered immunostimulatory adjuvants. The rationale for this approach is to ensure that both antigen and adjuvant are delivered into the same population of antigen-presenting cells. In addition, delivery systems can focus the effect of the adjuvants onto the key cells of the immune system and limit the systemic distribution of the adjuvant, to minimize its potential to induce adverse effects. The formulation and delivery of potent adjuvants in microparticles may allow the development of prophylactic and therapeutic vaccines against cancers and chronic infectious diseases, which are currently poorly controlled. In addition, microparticle formulations may also allow vaccines to be delivered mucosally.

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Citations

Cites

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Research works printed but not linked: 20

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Metadata

Authors
O’Hagan, D. T., & Singh, M.
ORCID
Singh, Manmohan
Venue
Expert Review of Vaccines
Publisher
Informa UK Limited
Published
2003-04
Volume
2
Issue
2
Pages
269-283
ISSN
  • 1476-0584 (ISSN-L)
  • 1744-8395
DOI
10.1586/14760584.2.2.269
OpenAlex
W2030951969
Cited by
214
References
155
Citations by year
2026: 1 · 2025: 1 · 2024: 5 · 2023: 7 · 2022: 4 · 2021: 10 · 2020: 10 · 2019: 3 · 2018: 3 · 2017: 6 · 2016: 7 · 2015: 10 · 2014: 8 · 2013: 9 · 2012: 23
FWCI
1.12
Type
journal article
Language
en
Open access
closed
Locations
  • Expert Review of Vaccines (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords
vaccine adjuvants, microparticles, vaccine delivery systems, immunostimulatory adjuvants, antigen-presenting cells, liposomes, emulsions, mucosal vaccine delivery, cancer vaccines
MeSH terms
Adjuvants, Immunologic, Animals, Antigens, Capsules, Humans, Immunity, Cellular, Lipid A, Microspheres, Oligodeoxyribonucleotides, Saponins, Vaccines, Cytokines, Drug Delivery Systems, Immunity, Mucosal, Vaccines, DNA

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