Cited by 214Immunotherapy and Immune ResponsesAdvanced Drug Delivery SystemsNanoparticle-Based Drug Delivery

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Microparticles as vaccine adjuvants and delivery systems

O’Hagan, Derek T, Singh, Manmohan·2003·Expert Review of Vaccines

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Abstract

Adjuvants can be broadly divided into two groups, based on their principal mechanisms of action: vaccine delivery systems and immunostimulatory adjuvants. Vaccine delivery systems are generally particulate (e.g., emulsions, microparticles, immunostimulatory complexes and liposomes) and function mainly to target associated antigens into antigen-presenting cells. However, increasingly, more complex formulations are being developed in which delivery systems are exploited both for the delivery of antigens and also for the delivery of coadministered immunostimulatory adjuvants. The rationale for this approach is to ensure that both antigen and adjuvant are delivered into the same population of antigen-presenting cells. In addition, delivery systems can focus the effect of the adjuvants onto the key cells of the immune system and limit the systemic distribution of the adjuvant, to minimize its potential to induce adverse effects. The formulation and delivery of potent adjuvants in microparticles may allow the development of prophylactic and therapeutic vaccines against cancers and chronic infectious diseases, which are currently poorly controlled. In addition, microparticle formulations may also allow vaccines to be delivered mucosally.

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Authors: O’Hagan, D. T., & Singh, M.
ORCID: Singh, Manmohan
Venue: Expert Review of Vaccines
Publisher: Informa UK Limited
Published: 2003-04
Volume: 2
Issue: 2
Pages: 269-283
ISSN: 1476-0584 (ISSN-L)
1744-8395
DOI: 10.1586/14760584.2.2.269
OpenAlex: W2030951969
Cited by: 214
References: 155
Citations by year: 2026: 1 · 2025: 1 · 2024: 5 · 2023: 7 · 2022: 4 · 2021: 10 · 2020: 10 · 2019: 3 · 2018: 3 · 2017: 6 · 2016: 7 · 2015: 10 · 2014: 8 · 2013: 9 · 2012: 23
FWCI: 1.12
Type: journal article
Language: en
Open access: closed
Locations: Expert Review of Vaccines (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords: vaccine adjuvants, microparticles, vaccine delivery systems, immunostimulatory adjuvants, antigen-presenting cells, liposomes, emulsions, mucosal vaccine delivery, cancer vaccines
MeSH terms: Adjuvants, Immunologic, Animals, Antigens, Capsules, Humans, Immunity, Cellular, Lipid A, Microspheres, Oligodeoxyribonucleotides, Saponins, Vaccines, Cytokines, Drug Delivery Systems, Immunity, Mucosal, Vaccines, DNA

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Microparticles as vaccine adjuvants and delivery systems

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