Cited by 439Inflammatory Biomarkers in Disease PrognosisInflammation biomarkers and pathwaysSepsis Diagnosis and Treatment

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Neutrophil to lymphocyte ratio (NLR) and cardiovascular diseases: an update

Afari, Maxwell E., Bhat, Tariq·2016·Expert Review of Cardiovascular Therapy

DOI 10.1586/14779072.2016.1154788

Open this paper in CoChat — free account

Abstract

As we know, inflammatory and oxidative stresses have a role in the pathogenesis of cardiovascular disease. This knowledge has triggered many investigations targeted to inflammatory markers. One such example, the neutrophil to lymphocyte ratio (NLR), is an inexpensive and easily accessible inflammatory marker whose role in cardiovascular disease has been studied extensively in the past few years. The neutrophil lymphocyte ratio has been shown to predict cardiac arrhythmias as well as short- and long-term mortality in patients with acute coronary syndromes (ACS). It has correlated well with ACS risk prediction models such as the GRACE and SYNTAX scores. A higher NLR has also been associated with frequent congestive heart failure decompensation and long-term mortality. The neutrophil to lymphocyte ratio also appears to have a prognostic role in patients undergoing transaortic valve replacement and the progression of valvular heart diseases. Despite the science of inflammatory biomarkers having been described decades ago, NLR appears to be enjoying a renaissance as a cost-effective biomarker with immediate clinical predictability and prognostication.

Integrity signals

Registry

Crossref · 10.1586/14779072.2016.1154788

Cites

0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Usefulness of neutrophil to lymphocyte ratio in predicting short- and long-term mortality after non-ST-elevation myocardial infarction
Azab, B., Zaher, M., Weiserbs, K. F., Torbey, E., Lacossiere, K., Gaddam, S., Gobunsuy, R., Jadonath, S., Baldari, D., McCord, D., et al. (2010) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2010.03.062 · Cited by 524

Flagged first, then by citations

Show all 0 references

Research works printed but not linked: 43

10.1016/j.clinbiochem.2013.05.070 · DOI
10.1586/erc.12.159 · DOI · Paper page
10.1161/01.CIR.96.10.3542 · DOI
10.1016/j.amjcard.2009.09.007 · DOI
10.1161/01.CIR.96.4.1180 · DOI
10.1016/j.arcmed.2015.03.011 · DOI
10.1016/j.amjcard.2013.04.015 · DOI
10.1016/j.ijcard.2013.05.042 · DOI
10.5152/akd.2013.036 · DOI
10.2174/187152911798346981 · DOI
10.5152/akd.2015.5927 · DOI
10.1016/j.jacc.2009.09.009 · DOI · Paper page
10.1160/TH11-02-0096 · DOI
10.1016/j.amjcard.2008.05.006 · DOI
10.1177/1076029613505763 · DOI
10.1016/j.cjca.2014.05.010 · DOI
10.1177/1076029613519851 · DOI
10.6061/clinics/2015(01)07 · DOI
10.1097/MBC.0000000000000227 · DOI
10.1536/ihj.14-175 · DOI
10.1177/1076029612465669 · DOI
10.1371/journal.pone.0133934 · DOI
10.1177/0003319714542997 · DOI
10.1016/j.jacc.2005.02.054 · DOI
10.1177/0003319711412763 · DOI
Verdoia M, 2016, Angiology
10.1177/1076029612473517 · DOI
10.5551/jat.25940 · DOI
10.1186/1471-2261-14-130 · DOI
10.1161/01.RES.0000150734.79804.92 · DOI
10.1016/j.amjcard.2010.09.039 · DOI
10.1016/j.amjcard.2014.10.008 · DOI
10.5935/abc.20150126 · DOI
10.5543/tkda.2014.16363 · DOI
10.12659/MSM.883915 · DOI
10.1097/MAT.0000000000000267 · DOI
10.2147/JBM.S82423 · DOI
10.1177/1076029613514131 · DOI
Varol E, 2014, Blood Coagul Fibrinolysis, 25, 557, 10.1097/MBC.0000000000000094 · DOI
10.1111/echo.12534 · DOI
Castro-Dominguez Y, 2015, J Am Coll Cardiol, 66
10.1177/1076029614531449 · DOI
10.1038/nri2415 · DOI

Sorted by citations

Items 101–200 of 396

Association of neutrophil-to-lymphocyte ratio with outcomes after elective abdominal aortic aneurysm repair.
Bath, J., Smith, J. B., Kruse, R., & Vogel, T. R. (2019) · Journal of Vascular Nursing · doi:10.1016/j.jvn.2019.06.001 · Cited by 23
Increased Systemic Immune-Inflammation Index as a Novel Indicator of Alzheimer’s Disease Severity
Algul, F. E., & Kaplan, Y. (2024) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/08919887241280880 · Cited by 22
Short-term exposure to air pollution on peripheral white blood cells and inflammation biomarkers: a cross-sectional study on rural residents
Yang, Y., Wu, H., Zeng, Y., Xu, F., Zhao, S., Zhang, L., An, Z., Li, H., Li, J., Song, J., et al. (2024) · BMC Public Health · doi:10.1186/s12889-024-19116-2 · Cited by 23
“NLR has been proposed as a more sensitive and systemic biomarker of inflammation and immune responses induced by diverse stimuli [36–39].”
Background
Extra Virgin Olive Oil and Cardiovascular Protection in Chronic Kidney Disease
Marrone, G., Urciuoli, S., Lauro, M. D., Ruzzolini, J., Ieri, F., Vignolini, P., Daniele, F. D., Guerriero, C., Nediani, C., Daniele, N. D., et al. (2022) · Nutrients · doi:10.3390/nu14204265 · Cited by 22
“In particular, NLR appears to be a reliable predictor of cardiac arrhythmia and it represents a short- and long-term biomarker of CV disease [63].”
Background
The association of neutrophil–lymphocyte ratio and platelet–lymphocyte ratio with retinal vein occlusion: a systematic review and meta‐analysis
Liu, Z.-Y., Perry, L., Penny-Dimri, J., Raveendran, D., Hu, M. L., Arslan, J., Britten-Jones, A. C., O’Hare, F., Ayton, L., & Edwards, T. L. (2021) · Acta ophthalmologica · doi:10.1111/aos.14955 · Cited by 22
“As the ratio of neutrophils to lymphocytes, NLR has also been found to be elevated in atherosclerosis (Balta et al. 2016) and cardiovascular disease (Afari & Bhat 2016).”
Background
Elevated preoperative neutrophil‐to‐lymphocyte ratio predicts early adverse outcomes in uncomplicated type B aortic dissection undergoing TEVAR
Zhu, H.-Q., Zhang, L., Liang, T.-P., Li, Y.-M., Zhou, J., & Jing, Z. (2020) · BMC Cardiovascular Disorders · doi:10.1186/s12872-021-01904-y · Cited by 22
Neutrophil-to-lymphocyte ratio predicts coronary artery lesion severity and long-term cardiovascular mortality in patients with unstable angina pectoris
Li, S., Chen, H., Zhou, L., Cui, H., Liang, S.-W., & Li, H.-W. (2022) · Acta Cardiologica · doi:10.1080/00015385.2021.1963564 · Cited by 21
“NLR, a composite parameter indicated systemic inflammatory, was discovered to be significantly correlated with cardiovascular disease [14].”
Background
An Effective Machine Learning Approach for Identifying Non-Severe and Severe Coronavirus Disease 2019 Patients in a Rural Chinese Population: The Wenzhou Retrospective Study
Wu, P., Ye, H., Cai, X., Li, C., Li, S., Chen, M., Wang, M., Heidari, A. A., Chen, M., Li, J., et al. (2021) · IEEE Access · doi:10.1109/access.2021.3067311 · Cited by 24
Spectrophotometric determination of platelet counts in platelet-rich plasma
Kitamura, Y., Suzuki, M., Tsukioka, T., Isobe, K., Tsujino, T., Watanabe, T., Watanabe, T., Okudera, H., Nakata, K., Tanaka, T., et al. (2018) · International Journal of Implant Dentistry · doi:10.1186/s40729-018-0140-8 · Cited by 21
DEL-1 deficiency aggravates pressure overload-induced heart failure by promoting neutrophil infiltration and neutrophil extracellular traps formation.
Zhao, M.-M., Zheng, Z.-H., Yin, Z., Zhang, J., Peng, S.-S., Liu, J.-F., Pan, W., Wei, C., Xu, Y., Qin, J.-J., et al. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115912 · Cited by 20
Application of the ALBI Scoring System for Mortality Outcome Prediction in Patients with Hypertrophic Cardiomyopathy
Qiao, P., Li, L.-Y., Ruan, H.-Y., Zhang, M.-X., Wang, Z.-Q., Li, X., Shi, R., Wei, X., Duan, L.-J., Zheng, Y., et al. (2022) · Global Heart · doi:10.5334/gh.1163 · Cited by 20
Pathophysiology of Heart Failure: A Role for Peripheral Blood Mononuclear Cells Mitochondrial Dysfunction?
Sauer, F., Riou, M., Charles, A., Meyer, A., Andrès, E., Gény, B., & Talha, S. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11030741 · Cited by 25
Neutrophil‐to‐lymphocyte and platelet‐to‐lymphocyte ratios as prognostic biomarkers in polycythemia vera
Krečak, I., Holik, H., Perić, M. M., Zekanović, I., Coha, B., Krečak, M. V., Gverić-Krečak, V., & Lucijanić, M. (2021) · International Journal of Laboratory Hematology · doi:10.1111/ijlh.13786 · Cited by 20
Neutrophil-lymphocyte and platelet-lymphocyte ratios among adolescents with bipolar disorder: A preliminary study
Binici, N. C., Güney, S. A., & Emiroglu, F. N. I. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.08.065 · Cited by 23
Exploring the relations of NLR, hsCRP and MCP-1 with type 2 diabetic kidney disease: a cross-sectional study
Fang, Y., Wang, B., Pang, B., Zhou, Z., Xing, Y., Pang, P., Zheng, D., Zhang, G., & Yang, B. (2024) · Scientific Reports · doi:10.1038/s41598-024-53567-2 · Cited by 21
“Therefore, NLR can be considered a marker of severity in many inflammation-associated diseases 15,16 and is more predictive than assessing either parameter independently.”
Background
The Predictive Role of Hematological Parameters in Hypertension
Meng, X.-Z., Sun, H., Tu, X., & Li, W. (2023) · Angiology · doi:10.1177/00033197231190423 · Cited by 19
Could the systemic immune-inflammation index be a predictor to estimate cerebrovascular events in hypertensive patients?
Aydın, C., Alpsoy, Ş., Akyüz, A., Gür, D. Ö., Emlek, N., Şahin, A., Gültekin, A., & Aykaç, H. (2021) · Blood Pressure Monitoring · doi:10.1097/mbp.0000000000000560 · Cited by 19
Infectious and lifestyle modifiers of immunity and host resilience
Bajpai, G., & Nahrendorf, M. (2021) · Immunity · doi:10.1016/j.immuni.2021.05.011 · Cited by 27
Hemogram parameters in childhood anxiety disorders: Could anxiety disorders be related with inflammation?
Uzun, N., & Akıncı, M. A. (2020) · Medical Hypotheses · doi:10.1016/j.mehy.2020.110440 · Cited by 23
The Role of Inflammatory Hematological Markers in Predicting IVF Success
Ozgu-Erdinc, A., Çoşkun, B., Yorgancı, A., Hançerlioğulları, N., Yılmaz, N., & Engin-Üstün, Y. (2020) · JBRA Assisted Reproduction · doi:10.5935/1518-0557.20200050 · Cited by 19
“Neutrophil to lymphocyte ratio (NLR), monocyte to lymphocyte ratio (MLR), and platelet to lymphocyte ratio (PLR) are other hematological markers that show systemic inflammatory status (Afari & Bhat, 2016; Hwang et al., 2017; Wang et al., 2018; Nishijima et al., 2015).”
Background
Neutrophil-to-lymphocyte ratio is a predictor of renal dysfunction in Japanese patients with type 2 diabetes
Akase, T., Kawamoto, R., Ninomiya, D., Kikuchi, A., & Kumagi, T. (2020) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2020.04.029 · Cited by 18
Multiple preoperative biomarkers are associated with incidence of surgical site infection following surgeries of ankle fractures
Liu, D., Zhu, Y.-B., Chen, W., Li, M., Liu, S., & Zhang, Y.-Z. (2020) · International Wound Journal · doi:10.1111/iwj.13351 · Cited by 19
Monitoring the Prognosis of Diabetic Foot Ulcers: Predictive Value of Neutrophil-to-Lymphocyte Ratio and Red Blood Cell Distribution Width
Arıcan, G., Kahraman, H., Özmeriç, A., Iltar, S., & Alemdaroğlu, K. (2020) · International Journal of Lower Extremity Wounds · doi:10.1177/1534734620904819 · Cited by 19
Neutrophil-to-lymphocyte ratio is associated with coronary microvascular dysfunction in type 2 diabetes mellitus patients
Chen, Y., Chai, Q., Wang, Q., Zhang, Z., Shan, Y., Lu, D., Liu, M., & Wu, W. (2021) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2021.108983 · Cited by 20
How Immunonutritional Markers Are Associated with Age, Sex, Body Mass Index and the Most Common Chronic Diseases in the Hospitalized Geriatric Population—A Cross Sectional Study
Stephenson, S. S., Kravchenko, G., Korycka-Błoch, R., Kostka, T., & Sołtysik, B. (2024) · Nutrients · doi:10.3390/nu16152464 · Cited by 17
Predictive value of neutrophil to lymphocyte ratio for ischemic stroke in patients with atrial fibrillation: A meta-analysis
Lu, M., Zhang, Y., Liu, R., He, X., & Hou, B.-N. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.1029010 · Cited by 17
Value of the Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio in Predicting CPET Performance in Patients with Stable CAD and Recent Elective PCI
Drugescu, A., Roca, M., Zota, I. M., Costache, A. D., Gavril, O. I., Gavril, R. S., Vasilcu, T. F., Mitu, O., Eşanu, I., Roca, I.-C., et al. (2022) · Medicina · doi:10.3390/medicina58060814 · Cited by 17
“NLR is an easily available biomarker of vascular parietal inflammation [63] with documented prognostic implications in various cardiovascular diseases [64].”
Background
Mean platelet volume, neutrophil- and platelet to lymphocyte ratios are elevated in vestibular neuritis.
Şahin, M., Kökoğlu, K., & Gülmez, E. (2019) · Journal of clinical neuroscience · doi:10.1016/j.jocn.2019.05.062 · Cited by 17
Screening genes associated with elevated neutrophil-to-lymphocyte ratio in chronic heart failure
Wan, G.-X., Ji, L., Xia, W., Cheng, L., & Zhang, Y.-G. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.9132 · Cited by 17
“Neutrophil-to-lymphocyte ratio (NLR), a new addition to the list of systemic inflammatory biomarkers, has been repeatedly reported as a prognostic marker and a risk stratification index for various cardiovascular diseases including HF by numerous studies (5,6).”
Influential
The impact of platelet-to-lymphocyte ratio on clinical outcomes in heart failure: a systematic review and meta-analysis
Vakhshoori, M., Bondariyan, N., Sabouhi, S., Kiani, K., Faradonbeh, N. A., Emami, S. A., Shakarami, M., Khanizadeh, F., Sanaei, S., Motamedi, N., et al. (2024) · Therapeutic Advances in Cardiovascular Disease · doi:10.1177/17539447241227287 · Cited by 23
“52,53 Although the exact pathophysiological mechanism for HF is still not defined, several theoretical mechanisms are proposed.”
Background
Prognostic Efficacy of Complete Blood Count Indices for Assessing the Presence and the Progression of Myxomatous Mitral Valve Disease in Dogs
Jung, M.-J., & Kim, J.-H. (2023) · Animals · doi:10.3390/ani13182821 · Cited by 16
“Indeed, increased NLR and MLR are associated with cardiovascular diseases, such as coronary artery disease, stroke, mitral valve disease, and adverse cardiac events [9,13,14].”
BackgroundResult
Diagnostic value of procalcitonin, hypersensitive C-reactive protein and neutrophil-to-lymphocyte ratio for bloodstream infections in pediatric tumor patients
Li, D., Li, J., Zhao, C.-X., Liao, X.-Y., Liu, L.-S., Xie, L., & Shang, W.-Q. (2022) · Clinical Chemistry and Laboratory Medicine · doi:10.1515/cclm-2022-0801 · Cited by 16
Predictive Performances of Blood Parameter Ratios for Liver Inflammation and Advanced Liver Fibrosis in Chronic Hepatitis B Infection
Ding, R., Zhou, X.-L., Huang, D., Wang, Y.-B., Li, X.-F., Yan, L., Lu, W.-H., Yang, Z.-G., & Zhang, Z.-Q. (2021) · BioMed Research International · doi:10.1155/2021/6644855 · Cited by 16
“NLR has been associated to various inflammations and cardiovascular diseases [17, 32, 33].”
Background
The Role of Neutrophils in Multiple Sclerosis and Ischemic Stroke
Nowaczewska-Kuchta, A., Ksiazek-Winiarek, D. J., Szpakowski, P., & Glabinski, A. R. (2024) · Brain Sciences · doi:10.3390/brainsci14050423 · Cited by 16
“The neutrophil-to-lymphocyte ratio (NLR) has been used as a marker of, for example, cardiovascular diseases, cancer, and diabetes [139–141].”
Method
Immunohematologic Biomarkers in COVID-19: Insights into Pathogenesis, Prognosis, and Prevention
Sweet, D. R., Freeman, M. L., & Zidar, D. A. (2023) · Pathogens and Immunity · doi:10.20411/pai.v8i1.572 · Cited by 15
Biomarkers as a Prognostic Factor in COPD Exacerbation: A Cohort Study
Gómez-Rosero, J. A., Cáceres-Galvis, C., Ascuntar, J., Atencia, C., Vallejo, C., & Jaimes, F. (2021) · COPD · doi:10.1080/15412555.2021.1922370 · Cited by 15
Variability in blood lipids affects the neutrophil to lymphocyte ratio in patients undergoing elective percutaneous coronary intervention: a retrospective study
Zhao, L., Xu, T., Li, Y., Luan, Y., Lv, Q., Fu, G., & Zhang, W. (2020) · Lipids in Health and Disease · doi:10.1186/s12944-020-01304-9 · Cited by 17
The value of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) parameters in analysis with fetal malnutrition neonates
Can, E., & Can, C. (2019) · Journal of Perinatal Medicine · doi:10.1515/jpm-2019-0016 · Cited by 15
Relationship between neutrophil/lymphocyte ratio and epicardial fat tissue thickness in patients with newly diagnosed hypertension
Derya, M. A., Demir, V., & Ede, H. (2018) · Journal of International Medical Research · doi:10.1177/0300060517749130 · Cited by 15
“cardiovascular disease or risk factors.(24,25) Examples of these hematological parameters include the NLR; RDW; platelet/ lymphocyte ratio; neutrophil, monocyte, and basophil counts; hemoglobin; hematocrit; red blood cell count; and micro- and macrocytosis.”
Background
Association Between Mood Disorder Severity, Treatment Response and Systemic Inflammatory Markers: Exploring the Role of NLR, PLR, MLR, and SII
Department of Psychiatry, G. U., Kucukkarapinar, M., Erbil, D., Department of Psychiatry, G. U., Keles, İ., Department of Psychiatry, G. U., Karadag, F., & Department of Psychiatry, G. U. (2024) · Psychiatry and Clinical Psychopharmacology · doi:10.5152/pcp.2024.23760 · Cited by 14
Effect of inflammation on association between cancer and coronary artery disease
Sun, M., Zhu, S., Wang, Y.-H., Zhao, Y.-W., Yan, K.-X., Li, X., Wang, X., He, C., Ding, C.-H., Chen, Y.-D., et al. (2024) · BMC Cardiovascular Disorders · doi:10.1186/s12872-023-03613-0 · Cited by 14
“NLR independently predicts atherosclerotic events and is a potential biomarker for residual inflammatory risk [7, 20].”
Background
A high platelet-to-lymphocyte ratio predicts all-cause mortality and cardiovascular mortality in maintenance hemodialysis patients
Zhang, Y., Zhang, A., Wei, L., Ren, K., Wang, Q., Shao, B., Zhao, C., Ren, Z., Bai, J.-X., & Cao, N. (2023) · Renal Failure · doi:10.1080/0886022x.2023.2258228 · Cited by 15
“NLR, as a novel inflammatory marker, has also become a predictor of poor prognosis in cancer and cardio-vascular diseases in the general population [10,21].”
Background
Evaluation of subclinical atherosclerosis in rosacea patients by flow‐mediated dilatation method
Caf, N., Akbulut, T. Ö., Can, M., Sarı, M., Atsü, A. N., & Türkoğlu, Z. (2022) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.15492 · Cited by 14
Seasonal Changes of Growth, Immune Parameters and Liver Function in Wild Chinese Sturgeons Under Indoor Conditions: Implication for Artificial Rearing
Zheng, Y., Zhang, Y., Xie, Z., Shin, P. K., Xu, J.-N., Fan, H., Zhuang, P., Hu, M.-H., & Wang, Y. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.894729 · Cited by 14
Association of Derived Neutrophil-To-Lymphocyte Ratio With Prognosis of Coronary Heart Disease After PCI
Gang-qiong, L., Zhang, W., Shangguan, J., Zhu, X., Wang, W., Guo, Q., Zhang, J., Wang, K., Liu, Z., Song, F.-H., et al. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.705862 · Cited by 19
Long-term Prognosis after Treatment of Total Occluded Coronary Artery is well Predicted by Neutrophil to High-Density Lipoprotein Ratio: a Comparison Study.
Özgeyik, M., & Ozgeyik, M. (2021) · Kardiologiia · doi:10.18087/cardio.2021.7.n1637 · Cited by 14
Neutrophil-to-Lymphocyte Ratio and Treatment Failure in Peritoneal Dialysis-Associated Peritonitis
He, P., He, L.-J., Huang, C., Hu, J.-P., & Sun, S.-R. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.699502 · Cited by 14
Complete blood count parameters and neutrophil-to-lymphocyte ratio values as markers for differentiation between systemic infectious and non-infectious uveitis
Balci, S. Y., Turan-vural, E., Turkyılmaz, O., Esen, F., & Aksaray, S. (2020) · International ophtalmology · doi:10.1007/s10792-020-01487-1 · Cited by 14
Neutrophil-to-lymphocyte ratio decreases in obstructive sleep apnea treated with mandibular advancement devices
Al-Halawani, M., Naik, S., Chan, M., Kreinin, I., Meiers, J. C., & Kryger, M. H. (2018) · Sleep And Breathing · doi:10.1007/s11325-018-1635-5 · Cited by 17
The association between hematological markers of inflammation and chronic cannabis use: a systematic review and meta-analysis of observational studies
Moshfeghinia, R., Najibi, A., Moradi, M., Assadian, K., & Ahmadi, J. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1438002 · Cited by 13
“NLR has found applications in diverse ﬁ elds, serving as a prognostic indicator in cardiovascular diseases, assessing cancer-related in ﬂ ammation, and more (31 – 34).”
Background
Enhancing Pulmonary Embolism Mortality Risk Stratification Using Machine Learning: The Role of the Neutrophil-to-Lymphocyte Ratio
Teodoru, M., Negrea, M. O., Cozgarea, A., Cozma, D. C., & Boicean, A. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13051191 · Cited by 17
Neutrophil to lymphocyte ratio in pediatric patients with asthmatic exacerbation and community-acquired pneumonia
Xu, M., Zhou, L.-F., Zhang, J., Luo, S., Zhao, Y.-F., & Xiong, W. (2023) · BMC Pediatrics · doi:10.1186/s12887-023-04456-6 · Cited by 13
“It has been validated to be associated with a variety of morbidities mainly including infection [7], solid tumor [8], cardiovascular diseases [9], and pulmonary diseases which mainly comprise chronic obstructive pulmonary disease [10, 11], acute pulmonary embolism [12], acute respiratory distress…”
Background
The Association Between Neutrophil-Lymphocyte Ratio and Variability with New-Onset Dementia: A Population-Based Cohort Study
Chou, O., Zhou, J.-D., Li, L., Chan, J., Satti, D., Chou, V., Wong, W., Lee, S.-R., Cheung, B., Tse, G., et al. (2023) · Journal of Alzheimer's Disease · doi:10.3233/jad-220111 · Cited by 13
“NLR has been applied to predict the risks of cancer [13], cardiovascular diseases [14, 15], and other adverse outcomes [16–18].”
Systemic immune-inflammation index could be associated with pseudophakic cystoid macular edema after an uneventful phacoemulsification surgery in patients without risk factors
Kocamış, S. İ., Boz, A. A. E., & Özdemir, İ. (2022) · BMC Ophthalmology · doi:10.1186/s12886-022-02606-5 · Cited by 14
A Nomogram for Predicting In-Stent Restenosis Risk in Patients Undergoing Percutaneous Coronary Intervention: A Population-Based Analysis
Luo, Y.-B., Tan, N., Zhao, J., & Li, Y. (2022) · International Journal of General Medicine · doi:10.2147/ijgm.s357250 · Cited by 13
Neutrophil-to-lymphocyte ratio as a predictor of overall survival and cancer advancement in patients undergoing radical cystectomy for bladder cancer
Sudoł, D., Widz, D., Mitura, P., Płaza, P., Godzisz, M., Kuliniec, I., Yadlos, A., Cabanek, M., Bar, M., & Bar, K. (2022) · Central European Journal of Urology · doi:10.5173/ceju.2022.0273 · Cited by 13
Association of monocyte-lymphocyte ratio with in-hospital mortality in cardiac intensive care unit patients.
Zhai, G.-Y., Liu, Y.-Y., Wang, J., & Zhou, Y.-J. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107736 · Cited by 13
Progress in the application of the neutrophil-to-lymphocyte ratio in dialysis-related complications
Yang, N., Yang, K., Pan, S., He, Q., & Jin, J. (2023) · Renal Failure · doi:10.1080/0886022x.2023.2259996 · Cited by 14
A novel nomogram with preferable capability in predicting the overall survival of patients after radical esophageal cancer resection based on accessible clinical indicators: A comparison with AJCC staging
Li, X., Xu, J., Zhu, L., Yang, S.-J., Yu, L., Lv, W., & Hu, J. (2021) · Cancer Medicine · doi:10.1002/cam4.3878 · Cited by 12
Neutrophil-to-lymphocyte ratio but not monocyte-to-HDL cholesterol ratio nor platelet-to-lymphocyte ratio correlates with early stages of lower extremity arterial disease: an ultrasonographic study.
Santoro, L., Ferraro, P., Nesci, A., d'Alessandro, A., Macerola, N., Forni, F., Tartaglione, R., Vitis, R. D., Gasbarrini, A., & Santoliquido, A. (2021) · European Review for Medical and Pharmacological Sciences · doi:10.26355/eurrev_202105_25826 · Cited by 12
Role of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in Peyronie's disease: a new diagnostic approach to predict the stage of the disease?
Rojo, E., Gómez, B. G., de la Blanca, R. S., Manfredi, C., Isa, M. A., Polo, J. M., Antolín, A. R., & Otero, J. R. (2020) · Asian Journal of Andrology · doi:10.4103/aja.aja_74_20 · Cited by 12
Elevated AT1R Antibody and Morbidity in Patients Bridged to Heart Transplant using Continuous Flow Left Ventricular Assist Devices.
Chau, V., Flattery, M., Nicholson, K., Mcdougan, F., Gupta, G., Uber, P., Priday, A. G., Desai, K., Kimball, P., & Shah, K. (2020) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2020.06.010 · Cited by 12
Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio among Patients with Vestibular Neuritis
Shushan, S., Shemesh, S., Ungar, O., Cavel, O., Handzel, O., Tamir, S., & Oron, Y. (2019) · ORL · doi:10.1159/000502152 · Cited by 12
Impact of the Systemic Inflammatory Indices on Birth Weight: A Prospective Observational Study
Verde, M. L., Molitierno, R., Marrapodi, M., Fordellone, M., Laganá, A. S., Palma, M., Petillo, A., Riemma, G., Vastarella, M., & Franciscis, P. D. (2025) · Gynecologic and Obstetric Investigation · doi:10.1159/000545591 · Cited by 11
The Use of the Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio in Predicting Transcatheter Aortic Valve Implantation Mortality.
Nair, S., Ha, F., Baradi, A., Nanayakkara, S., Soden, L., Jin, D., Whitbourn, R., Wilson, A., & Palmer, S. (2024) · Heart, Lung and Circulation · doi:10.1016/j.hlc.2024.07.006 · Cited by 11
Association between the neutrophil-to-lymphocyte ratio and in-hospital mortality in patients with chronic kidney disease and coronary artery disease in the intensive care unit
Luo, J.-J., Zhou, Y.-F., Song, Y., Wang, D.-S., Li, M., Du, X.-L., Kang, J.-H., Ye, P., & Xia, J.-H. (2024) · European Journal of Medical Research · doi:10.1186/s40001-024-01850-3 · Cited by 11
“Importantly, the NLR functions as an easily accessible biomarker that indicates inflammation in the vascular wall [23], and its predictive importance has been recorded in different cardiovascular disorders [24].”
Background
Association of remnant cholesterol and newly diagnosed early‐onset type 2 diabetes mellitus in Chinese population: A retrospective cross‐sectional study
Dong, W., Yan, S., Chen, H., Zhao, J., Zhang, Z., & Gu, W. (2023) · Journal of Diabetes · doi:10.1111/1753-0407.13498 · Cited by 10
Predictive Value of the Changes in Neutrophil-Lymphocyte Ratio for Outcomes After Off-Pump Coronary Surgery
Bae, M. I., Shim, J., Song, J. W., Ko, S. H., Choi, Y. S., & Kwak, Y. L. (2023) · Journal of Inflammation Research · doi:10.2147/jir.s411057 · Cited by 14
“With the practical advantage of being able to measure neutrophil and lymphocyte counts through routine blood tests, NLR has been suggested as an easily accessible and cost-effective predictor of outcomes in cardiovascular disease and surgical patients.(12)”
Background
Relationships between Easily Available Biomarkers and Non-Dipper Blood Pressure Pattern in Patients with Stable Coronary Artery Disease
Drugescu, A., Roca, M., Zota, I., Costache, A., Leon-Constantin, M., Gavril, O., Gavril, R., Vasilcu, T., Mitu, O., Ghiciuc, C., et al. (2023) · Life · doi:10.3390/life13030640 · Cited by 11
Correlation analysis between the static and the changed neutrophil-to-lymphocyte ratio and in-hospital mortality in critical patients with acute heart failure
Liu, T., Wang, B., Xiao, S.-J., Sun, L., Zhu, Z., Wang, S., Li, B., Yao, J., Huang, C.-G., Ge, W.-G., et al. (2022) · Postgraduate medicine · doi:10.1080/00325481.2022.2129177 · Cited by 11
“accessible and cost-effective inflammation indicator, is computed utilizing neutrophils and lymphocytes, and its equation is as follows: NLR = neutrophils count/lymphocyte count [10].”
Background
Neutrophil-to-lymphocyte ratio as a predictor for cardiovascular diseases: a cohort study in Tianjin, China
Zhao, Y., Zhang, S., Yi, Y., Qu, T., Gao, S., Lin, Y., & Zhu, H. (2022) · Journal of Human Hypertension · doi:10.1038/s41371-022-00724-7 · Cited by 11
Galectin-3 and neutrophil-to-lymphocyte ratio are indicative of heart remodelling and disease severity in patients with obstructive sleep apnoea
Cicco, S., Castellana, G., Marra, L., Lecce, V. D., Carratù, P., Prete, M., Ranieri, G., Resta, O., Carpagnano, G. E., Racanelli, V., et al. (2021) · Sleep Medicine · doi:10.1016/j.sleep.2021.03.039 · Cited by 10
Exploring the Correlation between Systemic Inflammatory Markers and Carotid Atherosclerosis Indices in Middle-Aged Adults: A Cross-Sectional Study
Song, J., Hwang, J.-I., Ko, H.-J., Park, J.-Y., Hong, H.-E., & Kim, A. (2024) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd11030073 · Cited by 10
Association of preoperative neutrophil–lymphocyte ratios with the emergence delirium in pediatric patients after tonsillectomy and adenoidectomy: an observational prospective study
Feng, B., Guo, Y., Tang, S., Zhang, T., Gao, Y.-B., & Ni, X.-L. (2024) · Journal of Anesthesia · doi:10.1007/s00540-023-03303-3 · Cited by 10
“Peripheral blood cell parameters can be used as circulating biomarkers for systemic inflammation and they have been investigated in numerous diseases, including cardiovascular diseases and cancers [7, 8].”
Comparative analysis of neutrophil-to-lymphocyte ratio and remnant cholesterol in predicting cardiovascular events and mortality in general adult population
Wang, Q.-C., & Wang, Z.-Y. (2023) · Scientific Reports · doi:10.1038/s41598-023-49403-8 · Cited by 10
Critical limb ischemia patients clinically improving with medical treatment have lower neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios
Erdoğan, S., Selçuk, Ü. N., Baştopçu, M., Arslanhan, G., Çakmak, A. Y., Kuplay, H., Mete, E. M., & Aka, S. (2021) · Vascular · doi:10.1177/1708538120986294 · Cited by 10
The correlational study about neutrophil-to-lymphocyte ratio and exercise tolerance of chronic obstructive pulmonary disease patients
Yuan, L.-D., Li, L., Yu, T., Yang, Z.-L., Jiang, T., Ma, Q., Qi, J., Shi, Y., & Zhao, P.-G. (2020) · Medicine · doi:10.1097/md.0000000000021550 · Cited by 10
Platelet-to-Lymphocyte and Glucose-to-Lymphocyte Ratios as Prognostic Markers in Hospitalized Patients with Acute Coronary Syndrome
Kofos, C., Papazoglou, A., Fyntanidou, B., Samaras, A., Stachteas, P., Nasoufidou, A., Apostolopoulou, A., Karakasis, P., Arvanitaki, A., Bantidos, M. G., et al. (2025) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd12090334 · Cited by 9
“Blood-derived ratios such as NLR have been studied since the early 2010s in both oncology and cardiology as cost-effective inflammatory markers with prognostic potential [11,12].”
Systemic Coagulation Inflammation Index Associated With Bleeding in Acute Coronary Syndrome.
Zengin, I., & Severgun, K. (2023) · Kardiologiia · doi:10.18087/cardio.2023.10.n2586 · Cited by 9
Clinical significance of neutrophil-to-lymphocyte ratio on the risk of abdominal aortic calcification and decreased bone mineral density in patients with end-stage kidney disease
Ban, T. H., Choi, B. S., Yoon, S. A., Kim, Y., Jin, K., Kim, G., Lee, Y., Oh, K., Lee, S. H., Jung, J. Y., et al. (2023) · PLoS ONE · doi:10.1371/journal.pone.0286612 · Cited by 9
“The relationship between NLR and cardiovascular risk has been intensively studied in the general population and in patients with cardiovascular disease, and NLR was already confirmed as a potential predictor for cardiovascular risk in patients without CKD [28, 29].”
Background
The relation between apical thrombus formation and systemic immune-inflammation index in patients with acute anterior myocardial infarction
Tok, D., Ekizler, F., & Tak, B. T. (2022) · Medicine · doi:10.1097/md.0000000000032215 · Cited by 9
“[4] The SII reflects 3 important immune response pathways: inflammation which is represented by neutrophilia, thrombosis which is represented by platelets, and stress response which is reflected by lymphocyte.[9,10] However, the relation between SII levels and apical thrombous formation has not yet been studied before.”
Background
Association between haematological parameters and outcomes following transcatheter aortic valve implantation at mid-term follow-up
Abushouk, A. I., Agrawal, A., Hariri, E. H., Dykun, I., Kansara, T. M., Saad, A. M., Abdelfattah, O., Badwan, O. Z., Jaggi, C., Farwati, M., et al. (2022) · Open Heart · doi:10.1136/openhrt-2022-002108 · Cited by 10
Neutrophile-Lymphocyte Ratio and Outcome in Takotsubo Syndrome
Zweiker, D., Pogran, E., Gargiulo, L., El-Razek, A. A., Lechner, I., Vosko, I., Rechberger, S., Bugger, H., Christ, G., Bonderman, D., et al. (2022) · Biology · doi:10.3390/biology11081154 · Cited by 9
“NLR as an inflammatory marker has been identified as an outcome predictor for several cardiovascular diseases [32].”
Background
Network Pharmacology Study on Molecular Mechanisms of Zhishi Xiebai Guizhi Decoction in the Treatment of Coronary Heart Disease
Gao, J., Pan, Y., Zhao, Y.-X., Li, H., Mi, Z.-S., Chen, H., & Tan, X.-D. (2021) · Evidence-Based Complementary and Alternative Medicine · doi:10.1155/2021/3574321 · Cited by 9
Impact of small and dense low-density lipoprotein (sd-LDL)on contrast-induced acute kidney injury in patients with acute ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention
Li, Y.-H., Ma, K., Shen, G., Zheng, D., Xuan, Y., & Li, W. (2021) · International Urology and Nephrology · doi:10.1007/s11255-021-02821-x · Cited by 9
Prognostic value of the neutrophil-to-lymphocyte ratio in acute organophosphorus pesticide poisoning
Mu, Y.-H., Hu, B.-Q., Gao, N., & Pang, L. (2021) · Open Life Sciences · doi:10.1515/biol-2021-0069 · Cited by 9
The relationship between childhood obesity with inflammatory mediators.
Eren, C., & Çeçen, S. (2020) · JPMA. The Journal of the Pakistan Medical Association · doi:10.5455/jpma.27772 · Cited by 9
Elevated neutrophil to lymphocyte ratio is associated with poor long-term survival and graft failure after lung transplantation
Krishnan, A., Hsu, J., Ha, J. S., Broderick, S., Shah, P. D., Higgins, R. S. D., Merlo, C. A., & Bush, E. L. (2020) · The American Journal of Surgery · doi:10.1016/j.amjsurg.2020.04.007 · Cited by 11
Comparison of the clinical value of inflammatory blood biomarkers in relation to disease severity and survival in chronic heart failure.
Szymczak, A., Skwarek-Dziekanowska, A., Sobieszek, G., Małecka-Massalska, T., & Powrózek, T. (2025) · International Journal of Cardiology · doi:10.1016/j.ijcard.2025.133165 · Cited by 8
Neutrophil‐Lymphocyte Ratio as Predictor for Acute Infection After Primary Total Joint Arthroplasty in Rheumatoid Arthritis Patients
Lai, Y., Fan, J., Lv, N., Li, X., Zhao, W., Luo, Z., & Zhou, Z. (2025) · Orthopaedic Surgery · doi:10.1111/os.70002 · Cited by 10
“Elevated neutrophil counts represent activated nonspecific inflammation and are associated with increased oxidative stress, neutrophil extracellular capture, and endothelial dysfunction [22].”
Clinical comparative study of laparoscopic partial splenectomy and open partial splenectomy
Zeng, S., Wang, W., Chen, W., & Xiao, J.-B. (2024) · Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · doi:10.5114/wiitm.2024.139988 · Cited by 8
Neutrophil to lymphocyte ratio in captive olive baboons (Papio anubis): The effects of age, sex, rearing, stress, and pregnancy
Webb, S. J. N., Achorn, A. M., Schapiro, S. J., Hopkins, W. D., & Simmons, J. H. (2024) · American Journal of Primatology · doi:10.1002/ajp.23619 · Cited by 8
Neutrophil-lymphocyte ratio as a risk factor for osteoporotic vertebrae fractures and femoral neck fractures
Zhu, H., Li, Z., Zhou, Y., Zheng, R., Diao, C., Li, K.-P., Feng, Q., & Wang, D.-L. (2022) · Medicine · doi:10.1097/md.0000000000032125 · Cited by 8
“NLR is a simple, economical and easily available biomarker, which is commonly used in various malignant tumors and inflammatory diseases.[11,12] On the one hand, inflammation leads to primary disease; on the other hand, it will affect the skeletal system and interfere with bone metabolism, and inflammation plays a ver…”
Background
Neutrophil to lymphocyte ratio predicts permanent pacemaker implantation in TAVR patients
Totaro, A., Testa, G., Calafiore, A., Ienco, V., Sacra, V., Busti, A., Pierro, A., Sperlongano, S., Golino, P., & Sacra, C. (2022) · Journal of cardiac surgery · doi:10.1111/jocs.17212 · Cited by 8
“Neutrophil/lymphocyte ratio (NLR) has been proposed as a marker of inflammation and its ability to predict outcomes has been tested in several cardiac diseases.(9) In AS, NLR has been shown to be related to the severity of calcific AS, left ventricular (LV) disfunction,(10) and to be a predictor of major adverse cardi…”
Background
Association between neutrophil–lymphocyte ratio change during living donor liver transplantation and graft survival
Park, J., Lee, S. H., Gwak, M. S., Ko, J. S., Han, S., Choi, G., Joh, J., Kim, J. M., & Kim, G. S. (2021) · Scientific Reports · doi:10.1038/s41598-021-83814-9 · Cited by 10
The neutrophil-lymphocyte ratio and atherosclerosis
Balta, Ş., Ozturk, C., Yıldırım, A., Erdoğan, S., & Celik, T. (2016) · Expert Review of Cardiovascular Therapy · doi:10.1080/14779072.2016.1194199 · Cited by 8
“[1] in their review conclude that the neutrophil to lymphocyte ratio (NLR) may be enjoying a renaissance as an inflammatory biomarker.”
BackgroundInfluential
NEUTROPHIL-LYMPHOCYTE RATIO AND PLATELET-LYMPHOCYTE RATIO AS PREDICTORS OF CORONARY MICROCIRCULATORY DISEASE OCCURRENCE AND OUTCOME IN PATIENTS WITH CHRONIC CORONARY SYNDROME AND NO SIGNIFICANT CORONARY ARTERY STENOSIS
Szolc, P., Niewiara, Ł., Kawulak, M., Szkodoń, K., Ostrowska-Kaim, E., Nosal, M., Krzanowski, M., Zmudka, K. F., Legutko, J., & Guzik, B. (2020) · Wiadomości Lekarskie · doi:10.36740/wlek202012108 · Cited by 10
Rethinking Mitral Annular Calcification and Its Clinical Significance: From Passive Process to Active Pathology
Morariu, P. C., Oancea, A. F., Gosav, E. M., Buliga-Finiș, O. N., Cuciureanu, M. D., Scripcariu, D. V., Sîrbu, O., Godun, M. M., Floria, D., Chiriac, C. P., et al. (2024) · Journal of Personalized Medicine · doi:10.3390/jpm14090900 · Cited by 6
“Similarly, patients with severe aortic stenosis and preserved ejection fraction also showed significantly higher NLR levels than those with mild or moderate aortic stenosis [69].”
Background
A Systematic Review and Meta-Analysis of the Diagnostic Value of Galectin-3 in Acute Coronary Syndrome
Pruc, M., Gaca, Z., Świeczkowski, D., Kubica, J., Galwankar, S., Salak, A., & Szarpak, L. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13154504 · Cited by 7
“A significant group of these are based on inflammatory markers, e.g., the neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR) [6–8].”
The predictive value of systemic immune-inflammation index for long-term cardiovascular mortality in non-ST segment elevation myocardial infarction
Yaşan, M., Özel, R., Yıldız, A., Savaş, G., & Korkmaz, A. (2024) · Coronary Artery Disease · doi:10.1097/mca.0000000000001355 · Cited by 7
“They were found to be associated with mortality and adverse outcomes in various cardiovascular situations [12,13].”
Background

Authors: Afari, M. E., & Bhat, T.
Affiliations: Tufts University (US)
Corresponding author: Bhat, Tariq
ORCID: Afari, Maxwell E.
Venue: Expert Review of Cardiovascular Therapy
Publisher: Informa UK Limited
Published: 2016-03-04
Volume: 14
Issue: 5
Pages: 573-577
ISSN: 1477-9072 (ISSN-L)
1744-8344
DOI: 10.1586/14779072.2016.1154788
OpenAlex: W2285799691
Cited by: 439
References: 0
Citations by year: 2026: 31 · 2025: 48 · 2024: 55 · 2023: 63 · 2022: 72 · 2021: 63 · 2020: 46 · 2019: 26 · 2018: 19 · 2017: 10 · 2016: 6
FWCI: 2.04
Type: journal article
Language: en
Open access: closed
Locations: Expert Review of Cardiovascular Therapy (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
Keywords: neutrophil-to-lymphocyte ratio, inflammatory markers, cardiovascular disease, acute coronary syndrome, cardiac arrhythmias, mortality prediction, congestive heart failure, aortic valve replacement, valvular heart disease, oxidative stress, GRACE risk score, SYNTAX score
MeSH terms: Cardiovascular Diseases, Heart Failure, Humans, Lymphocytes, Neutrophils, Prognosis, Risk, Biomarkers, Disease Progression, Acute Coronary Syndrome

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Neutrophil to lymphocyte ratio (NLR) and cardiovascular diseases: an update

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Metadata

Record

About these checks