Long-Term Effect of Ubiquinol on Exercise Capacity and the Oxidative Stress Regulation System in SAMP1 Mice
Open accessAbstract
[Purpose] This study examined how exercise capacity and the oxidative stress regulation system are affected by different amounts of dietary Ubiquinol (reduced form of coenzyme Q10, H2CoQ10: QH) over the long term. [Subjects and Methods] Twenty-three senescence-accelerated mouse P1 (SAMP1) mice were randomly divided into two groups: one consuming a relatively high amount of QH (300 mg/kg; Group A) and the other a relatively low amount (30 mg/kg, Group B). Food and tap water were provided ad libitum. Both groups were made to run on a treadmill until exhaustion, and total running duration was measured. For the oxidative stress regulation system, the d-ROM test value (degree of oxidative stress) and BAP test value (antioxidant potential) were measured in a resting state, and then the BAP/d-ROM ratio (B/R ratio) was calculated. The values of plasma QH and plasma ubiquinone (plasma oxidized form of CoQ10) were also measured, and the reduced ratio was calculated. Measurements were taken 3 times: at the start of the study when the animals were 39 weeks old (baseline), after consumption of QH for 7 months (7 mo), and after consumption of QH for 10 months (10 mo). [Results] The senescence score at 10 mo was significantly lower in Group A. Comparison of the mean percentage change in running time showed a difference of 15.1% between the 2 groups. At 10 mo, the d-ROM test value was significantly increased and the B/R ratio was significantly decreased in Group B. Significant increases in the plasma QH value and reduced ratio were seen in Group A. [Conclusion] Group A showed a greater decrease in the d-ROM test and increase in the reduced ratio than Group B. Thus, a dose-dependent effect of QH consumption was demonstrated.
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In SAMP1 mice, ubiquinol administration at 250-300 mg/kg/day for at least 10 months can reduce senescence grading scores and ROS production, while enhancing antioxidant defences.
“In vivo, experiments conducted on SAMP1 mice reported that ubiquinol administration at relatively high doses (250–300 mg/kg/day) for at least 10 months can reduce senescence grading scores and ROS production, while enhancing antioxidant defences [68,70].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [70]
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Cited by
Sorted by citations
The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence
Varesi, A., Chirumbolo, S., Campagnoli, L. I. M., Pierella, E., Piccini, G. B., Carrara, A., Ricevuti, G., Scassellati, C., Bonvicini, C., & Pascale, A. (2022) · Antioxidants · doi:10.3390/antiox11071224 · Cited by 145 · see citing works
Andreani, C., Bartolacci, C., Guescini, M., Battistelli, M., Stocchi, V., Orlando, F., Provinciali, M., Amici, A., Marchini, C., Tiano, L., et al. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/8936251 · Cited by 37 · see citing works
- Authors
- Maruoka, H., Fujii, K., Inoue, K., & Kido, S.
- Affiliations
- Saitama Prefectural University (JP)
- Kaneka (Japan) (JP)
- Corresponding author
- Maruoka, Hiroshi
- Venue
- Journal of Physical Therapy Science
- Publisher
- Society of Physical Therapy Science
- Published
- 2014
- Volume
- 26
- Issue
- 3
- Pages
- 367-371
- ISSN
- 0915-5287 (ISSN-L)
- 2187-5626
- PMC
- PMC3976004
- OpenAlex
- W2062974757
- Cited by
- 13
- References
- 17
- Citations by year
- 2024: 2 · 2022: 2 · 2021: 2 · 2019: 1 · 2018: 2 · 2017: 2 · 2015: 1 · 2014: 1
- FWCI
- 0.55
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Journal of Physical Therapy Science (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- ubiquinol, coenzyme Q10, exercise capacity, oxidative stress, antioxidant capacity, SAMP1 mice, aging, senescence, dose-dependent effects, treadmill running
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