Cortisol, DHEA, and depression in the elderly: the influence of physical capacity
Open accessAbstract
OBJECTIVE: Major depression have been associated with cortisol and dehydroepiandrosterone (DHEA) changes in old depressed patients. We examined the association between depression, cortisol, and DHEA, correcting for confounding variables, including physical capacity. In addition, the association between hormone levels and physical capacity in these two experimental groups was also analyzed. METHOD: Depressed patients (n = 32) and healthy control (n = 31) old adults, both matched for age, were analyzed. Subjects were submitted to a physical capacity evaluation, including physical activity levels, functional fitness test, and balance scale. RESULTS: Depressed patients showed significant lower levels of cortisol than controls, which became non-significant after controlling for physical capacity. A positive correlation was observed between cortisol levels and physical capacity. CONCLUSIONS: The data suggest that physical capacity modulates the relationship between depression and cortisol levels and needs to be taken into consideration in the future investigations.
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Differences in basal cortisol between major depressive disorder and healthy control groups can be modulated by physical performance aspects.
“A previous study from our laboratory showed that the differences in basal cortisol between MDD and healthy control groups can be modulated by physical performance aspects.23”
From Can physical exercise modulate cortisol level in subjects with depression? A systematic review and meta-analysis (2018) · cites this paper as [23]
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Beserra, A. H. N., Kameda, P., Deslandes, A. C., Schuch, F. B., Laks, J., & Moraes, H. S. D. (2018) · Trends in Psychiatry and Psychotherapy · doi:10.1590/2237-6089-2017-0155 · Cited by 108 · see citing works
Self-citation
- Authors
- Moraes, H., Deslandes, A., Maciel-Pinheiro, P. D. T., Corrêa, H., & Laks, J.
- Affiliations
- Universidade Federal do Rio de Janeiro (BR)
- Universidade Federal do Rio de Janeiro, Brasil; Universidade Estadual do Rio de Janeiro, Brasil
- Universidade Federal de Minas Gerais (BR)
- Venue
- Arquivos de Neuro-Psiquiatria
- Publisher
- FapUNIFESP (SciELO)
- Published
- 2016-06
- Volume
- 74
- Issue
- 6
- Pages
- 456-461
- ISSN
- 0004-282X (ISSN-L)
- OpenAlex
- W2430915141
- Cited by
- 15
- References
- 25
- Citations by year
- 2024: 2 · 2022: 4 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 3 · 2017: 1
- FWCI
- 1.28
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Arquivos de Neuro-Psiquiatria (publishedVersion, cc-by)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- Americanae (AECID Library) (submittedVersion, cc-by-nc)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (E-26/, E-26/201)
- Universidade Federal do Rio de Janeiro
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Clinical Psychology › Health and Well-being Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- major depressive disorder, older adults, cortisol, dehydroepiandrosterone, physical capacity, functional fitness, physical activity, balance, glucocorticoids, sex hormones
- MeSH terms
- Aged, Cross-Sectional Studies, Dehydroepiandrosterone, Depression, Female, Humans, Hydrocortisone, Male, Middle Aged, Saliva, Biomarkers, Geriatric Assessment, Case-Control Studies
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