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Extracellular vesicles: structure, function, and potential clinical uses in renal diseases
Open accessAbstract
Interest in the role of extracellular vesicles in various diseases including cancer has been increasing. Extracellular vesicles include microvesicles, exosomes, apoptotic bodies, and argosomes, and are classified by size, content, synthesis, and function. Currently, the best characterized are exosomes and microvesicles. Exosomes are small vesicles (40-100 nm) involved in intercellular communication regardless of the distance between them. They are found in various biological fluids such as plasma, serum, and breast milk, and are formed from multivesicular bodies through the inward budding of the endosome membrane. Microvesicles are 100-1000 nm vesicles released from the cell by the outward budding of the plasma membrane. The therapeutic potential of extracellular vesicles is very broad, with applications including a route of drug delivery and as biomarkers for diagnosis. Extracellular vesicles extracted from stem cells may be used for treatment of many diseases including kidney diseases. This review highlights mechanisms of synthesis and function, and the potential uses of well-characterized extracellular vesicles, mainly exosomes, with a special focus on renal functions and diseases.
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Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
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Human saliva, plasma and breast milk exosomes contain RNA: Uptake by macrophages
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Cited by
Zhang, Y., Chopp, M., Meng, Y., Katakowski, M., Xin, H., Mahmood, A., & Xiong, Y. (2015) · Journal of neurosurgery · doi:10.3171/2014.11.jns14770 · Cited by 737
Gámez-Valero, A., Monguió-Tortajada, M., Carreras-Planella, L., Franquesa, M., Beyer, K., & Borràs, F. E. (2016) · Scientific Reports · doi:10.1038/srep33641 · Cited by 594
Berrondo, C., Flax, J., Kucherov, V., Siebert, A., Osinski, T., Rosenberg, A., Fucile, C., Richheimer, S., & Beckham, C. J. (2016) · PLOS ONE · doi:10.1371/journal.pone.0147236 · Cited by 266
Current advances in non‐viral gene delivery systems: Liposomes versus extracellular vesicles
Belhadj, Z., Qie, Y., Carney, R. P., Li, Y., & Nie, G. (2023) · BMEMat · doi:10.1002/bmm2.12018 · Cited by 79
Saadh, M. J., Ramírez-Coronel, A. A., Saini, R. S., Arias-Gonzáles, J. L., Amin, A. H., Gavilán, J. C. O., & Sârbu, I. (2023) · Human Cell · doi:10.1007/s13577-023-00904-8 · Cited by 30
Metadata
- Authors
- Borges, F. T., Reis, L. A., & Schor, N.
- Venue
- Brazilian Journal of Medical and Biological Research
- Publisher
- FapUNIFESP (SciELO)
- Published
- 2013-10
- Volume
- 46
- Issue
- 10
- Pages
- 824-830
- ISSN
- 0100-879X (ISSN-L)
- OpenAlex
- W2159041173
- Cited by
- 292
- References
- 5
- FWCI
- 3.09
- Type
- journal article
- Language
- en
- Open access
- gold
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- Borges, F. T., Reis, L. A., & Schor, N. (2013). Extracellular vesicles: structure, function, and potential clinical uses in renal diseases. Brazilian Journal of Medical and Biological Research. https://doi.org/10.1590/1414-431x20132964
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
