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Cited by 18Bipolar Disorder and TreatmentTryptophan and brain disordersNeuroinflammation and Neurodegeneration Mechanisms

Effects of lithium on inflammatory and neurotrophic factors after an immune challenge in a lisdexamfetamine animal model of mania

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Bristot, Giovana, Ascoli, Bruna M., Scotton, Ellen, Géa, Luiza P., Pfaffenseller, Bianca, Kauer-Sant’Anna, Márcia·2019·Brazilian Journal of Psychiatry
DOI 10.1590/1516-4446-2017-0001PMC PMC6796815
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Abstract

OBJECTIVE: To evaluate whether an animal model of mania induced by lisdexamfetamine dimesylate (LDX) has an inflammatory profile and whether immune activation by lipopolysaccharides (LPS) has a cumulative effect on subsequent stimuli in this model. We also evaluated the action of lithium (Li) on inflammatory and neurotrophic factors. METHODS: Adult male Wistar rats were subjected to an animal model of mania. After the open-field test, they were given LPS to induce systemic immune activation. Subsequently, the animals' blood was collected, and their serum levels of brain-derived neurotrophic factor and inflammatory markers (tumor necrosis factor [TNF]-α, interleukin [IL]-6, IL-1β, IL-10, and inducible nitric oxide synthase [iNOS]) were measured. RESULTS: LDX induced hyperactivity in the animals, but no inflammatory marker levels increased except brain-derived neurotrophic factor (BDNF). Li had no effect on serum BDNF levels but prevented iNOS levels from increasing in animals subjected to immune activation. CONCLUSION: Although Li prevented an LPS-induced increase in serum iNOS levels, its potential anti-inflammatory effects in this animal model of mania were conflicting.

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Authors
Bristot, G., Ascoli, B. M., Scotton, E., Géa, L. P., Pfaffenseller, B., & Kauer-Sant’Anna, M.
Affiliations
  • Universidade Federal do Rio Grande do Sul (BR)
  • Hospital de Clínicas de Porto Alegre, Brazil; UFRGS, Brazil
  • Hospital de Clínicas de Porto Alegre (BR)
  • Hospital de Clínicas de Porto Alegre, Brazil; Universidade Federal do Rio Grande do Sul (UFRGS), Brazil; UFRGS, Brazil
ORCID
Venue
Brazilian Journal of Psychiatry
Publisher
EDITORA SCIENTIFIC
Published
2019-10
Volume
41
Issue
5
Pages
419-427
ISSN
  • 1516-4446 (ISSN-L)
  • 1809-452X
DOI
10.1590/1516-4446-2017-0001
PMC
PMC6796815
OpenAlex
W2920098251
Cited by
18
References
2
Citations by year
2026: 1 · 2025: 3 · 2024: 5 · 2023: 3 · 2022: 3 · 2021: 3
FWCI
1.20
Type
journal article
Language
en
Open access
Licence
Locations
  • Brazilian Journal of Psychiatry (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
  • Americanae (AECID Library) (submittedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc-sa)
Funders
  • Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico
  • Hospital de Clínicas de Porto Alegre
  • Fundação Instituto de Pesquisas Econômicas
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
lithium, mania, lisdexamfetamine, animal model of mania, immune activation, lipopolysaccharide, neuroinflammation, brain-derived neurotrophic factor, inducible nitric oxide synthase, inflammatory cytokines, hyperactivity, bipolar disorder
MeSH terms
Lisdexamfetamine Dimesylate, Animals, Anti-Inflammatory Agents, Bipolar Disorder, Disease Models, Animal, Enzyme-Linked Immunosorbent Assay, Lipopolysaccharides, Lithium, Locomotion, Male, Nerve Growth Factors, Time Factors, Reproducibility of Results, Cytokines, Treatment Outcome, Rats, Wistar, Brain-Derived Neurotrophic Factor, Nitric Oxide Synthase Type II

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