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Cited by 138Oral microbiology and periodontitis researchOrthodontics and Dentofacial OrthopedicsDental Research and COVID-19

The influence of orthodontic fixed appliances on the oral microbiota: A systematic review

Open access
Freitas, Amanda Osório Ayres de, Marquezan, Mariana, Nojima, Matilde da Cunha Gonçalves, Alviano, Daniela Sales, Maia, Lucianne Cople·2014·Dental Press Journal of Orthodontics
DOI 10.1590/2176-9451.19.2.046-055.oarPMC PMC4296609
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Abstract

Objective: To investigate whether there is scientific evidence to support the hypothesis that the presence of orthodontic fixed appliances influences the oral microbiota. Methods: The search for articles was conducted in PubMed; ISI Web of Knowledge and Ovid databases, including articles published in English until May 17th, 2012. They should report human observational studies presenting the following keywords: "fixed orthodontic appliance" AND "microbiological colonization"; OR "periodontal pathogens"; OR "Streptococcus"; OR "Lactobacillus"; OR "Candida"; OR "Tannerella forsythia"; OR "Treponema denticola"; OR "Fusobacterium nucleatum"; OR "Actimomyces actinomycetemcomitans"; OR "Prevotella intermedia", OR "Prevotella nigrescens"; OR "Porphyromonas gingivalis". Articles were previously selected by title and abstract. Articles that met the inclusion criteria were analyzed and classified as having low, moderate or high methodology quality. A new detailed checklist for quality assessment was developed based on the information required for applicable data extraction for reviews. The study design, sample, follow-up period, collection and microbial analysis methods, statistical treatment, results and discussion were assessed. Results: The initial search retrieved 305 articles of which 33 articles were selected by title and abstract. After full-text reading, 8 articles met the inclusion criteria, out of which 4 articles were classified as having low and 4 as moderate methodological quality. The moderate methodological quality studies were included in the systematic review. Conclusions: The literature revealed moderate evidence that the presence of fixed appliances influences the quantity and quality of oral microbiota.

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References 31 · Cited by 138

Research works printed but not linked: 26

  1. [2]Balenseifen JW Madonia JV Study of dental plaque in orthodontic patients J Dent Res 1970 49 2 320 324 5264596
  2. [3]Chin MYH Busscher HJ Evans R Noar J Pratten E Early biofilm formation and the effects of antimicrobial agents on orthodontics bonding materials in a parallel plate flow chamber Eur J Orthod 2006 28 1 1 7 16373451
  3. [4]Friedman M Harari D Raz H Golomb G Brayer L Plaque Inhibition by sustained of Chlorhexidine from removable appliances J Dent Res 1985 64 11 1319 1321 3867693
  4. [5]Hagg U Kaveewatcharanont P Samaranayake YH Samaranayake LP The effect of fixed orthodontic appliances on the oral carriage of candida species and enterobacteriaceae Eur J Orthod 2004 26 6 623 629 15650072
  5. [6]Olympio KPK Bardal PAP Henriques JFC Bastos JRM Prevenção da cárie dentária e doença periodontal em Ortodontia: uma necessidade imprescindível Rev Dental Press Ortodon Ortop Facial 2006 11 2 110 119
  6. [7]Sukontapatipark W El-Agroudi MA Selliseth NJ Thunold K Selvig KA Bacterial colonization associated with fixed orthodontic appliances. A scanning electron microscopy study Eur J Orthod 2001 23 5 475 484 11668867
  7. [8]Brêtas SM Macari S Elias AM Ito IY Matsumoto MAN Effect of 0.44% fluoride gel on Streptococci mutans in relation to elastomeric rings and steel ligatures in orthodontic patients Am J Orthod Dentofacial Orthop 2005 127 4 428 433 15821687
  8. [9]Chun M Shim E Kho E Park K Jung J Kim J et al Surface modification of orthodontic wires photocatalytic titanium oxide for its antiadherent and antibacterial properties Angle Orthod 2007 77 3 483 488 17465657
  9. [10]Souza RA Magnani MBBA Nouer DF Silva CO Klein MI Sallum EA et al Periodontal and microbiologic evaluation of 2 methods of archwire ligation: ligature wires and elastomeric rings Am J Orthod Dentofacial Orthop 2008 134 4 506 512 18929268
  10. [11]Tukkahraman H Ozgur S Bozkurt FY Yetkin Z Kaya S Onal S Archwire ligation techniques, microbial colonization, and periodontal status in orthodontically treated patients Angle Orthod 2005 75 2 231 236 15825788
  11. [12]Gorelick L Geiber AM Gwinnett AJ Incidence of white spot formation after bonding and banding Am J Orthod Dentofacial Orthop 1982 81 2 93 98 6758594
  12. [13]Naranjo AA Triviño ML Jaramillo A Betancourth M Botero JE Changes in the subgingival microbiota and periodontal parameters before and 3 months after bracket placement Am J Orthod Dentofacial Orthop 2006 130 3 275.e17 275.e22 16979483
  13. [14]Thornberg MJ Riolo CS Bayirli B Riolo ML Van Tubergen EA Kulbersh R Periodontal pathogen levels in adolescents before, during and after fixed orthodontic appliance therapy Am J Orthod Dentofacial Orthop 2009 135 1 95 98 19121507
  14. [15]Bloom RH Brown LRJR Study of the effects of orthodontic appliances on the oral microflora Oral Surg Oral Med Oral Pathol 1964 17 658 667 14131587
  15. [17]Walker MP Ries D Kula K Ellis M Fricke B Mechanical properties and surface characterization of beta titanium and stainless steel orthodontic wire following topical fluoride treatment Angle Orthod 2007 77 2 342 348 17319772
  16. [18]Moher D Liberati A Tetzlaff J Altman DG The PRISMA Group 2009 Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement PLoS Med 2009 Access in August 15 2010 6 6 Available from: http://www.prisma-statement.org/statement.htm PMC3090117 21603045
  17. [20]Sinclair M Berry CW Bennet CL Israelson H Changes in gingival and gingival flora with bonding and banding Angle Orthod 1987 57 4 271 278 3479031
  18. [21]Ristic M Vlahovic SM Sasic M Zelic O Clinical and microbiological effects of fixed orthodontic appliances on periodontal tissues in adolescents Orthod Craniofac Res 2007 10 4 187 195 17973685
  19. [22]Paolantonio M Festa F Di Placido G D' Attilio M Catamo G Piccolomini R Site-specific subgingival colonization by Actinobacillus actinomycetencomitans in orthodontic patients Am J Orthod Dentofacial Orthop 1999 115 4 423 428 10194288
  20. [23]Paolantonio M Pedrazzoli V Di Muro C di Placido G Picciani C Catamo G et al Clinical significance of actinobacillus actinomycetemcomitans in young individuals during orthodontic treatment J Clin Periodontol 1997 24 9 Pt 1 610 617 9378831
  21. [24]Morikawa M Chiba T Tomii N Sato S Takahashi Y Konishi K et al Comparative analysis of putative periodontopathic bacteria by Multiplex Polymerase Chain Reaction J Periodont Res 2008 43 268 274 18447853
  22. [25]Sakamoto M Takeuchi Y Umeda M Ishikawa I Benno Y Rapid detection and quantification of five periodontopathic bacteria by Real-Time PCR Microbiol Immunol 2001 45 1 39 44 11270605
  23. [26]Jervoe-Storm PM Alahdab H Koltzscher M Fimmers R Jepsen S Comparison of curet and paper point sampling of subgingival bacteria as analyzed by real-time polymerase chain reaction J Periodontol 2007 78 5 909 917 17470026
  24. [27]Jordan C Leblanc DJ Influences of orthodontic appliances on oral populations of mutans streptococci Oral Microbiol Immunol 2002 17 2 65 71 11929551
  25. [28]Andrucioli MCD Nelson-Filho P Matsumoto MAN Saraiva MCP Feres M Figueiredo LC et al Molecular detection of in-vivo microbial contamination of metallic orthodontic brackets by checkerboard DNA-DNA hybridization Am J Orthod Dentofacial Orthop 2012 141 1 24 29 22196182
  26. [29]Heuer W Elter C Demling A Neumann A Suerbaum S Hannig M et al Analysis of early biofilm formation on oral implants in man J Oral Rehabil 2007 34 5 377 382 17441878

Authors
Freitas, A. O. A. D., Marquezan, M., Nojima, M. D. C. G., Alviano, D. S., & Maia, L. C.
Affiliations
  • Universidade Federal do Rio de Janeiro (BR)
  • Case Western Reserve University (US)
  • Universidade Federal Fluminense (BR)
Corresponding author
Freitas, Amanda Osório Ayres de
ORCID
Venue
Dental Press Journal of Orthodontics
Publisher
FapUNIFESP (SciELO)
Published
2014-04
Volume
19
Issue
2
Pages
46-55
ISSN
2176-9451 (ISSN-L)
DOI
10.1590/2176-9451.19.2.046-055.oar
PMC
PMC4296609
OpenAlex
W2102659434
Cited by
138
References
31
Citations by year
2026: 14 · 2025: 13 · 2024: 18 · 2023: 8 · 2022: 20 · 2021: 12 · 2020: 15 · 2019: 10 · 2018: 9 · 2017: 6 · 2016: 10 · 2015: 3
FWCI
1.07
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • Dental Press Journal of Orthodontics (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
  • Americanae (AECID Library) (submittedVersion, cc-by-nc)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
  • Health Sciences › Dentistry › Orthodontics › Orthodontics and Dentofacial Orthopedics
  • Health Sciences › Dentistry › General Dentistry › Dental Research and COVID-19
Keywords
fixed orthodontic appliances, oral microbiota, periodontal pathogens, Streptococcus, Lactobacillus, Candida, Tannerella forsythia, Treponema denticola, Fusobacterium nucleatum, Aggregatibacter actinomycetemcomitans, Prevotella intermedia, Porphyromonas gingivalis, microbial colonization
MeSH terms
Bacteria, Dental Plaque, Humans, Mouth, Orthodontic Appliances

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