The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Validation of HOMA-IR in a model of insulin-resistance induced by a high-fat diet in Wistar rats
Open accessAbstract
Objective The present study aimed to validate homeostasis model assessment of insulin resistance (HOMA-IR) in relation to the insulin tolerance test (ITT) in a model of insulin-resistance in Wistar rats induced by a 19-week high-fat diet. Materials and methods A total of 30 male Wistar rats weighing 200-300 g were allocated into a high-fat diet group (HFD) (55% fat-enriched chow, ad lib, n = 15) and a standard-diet group (CD) standard chow, ad lib, n = 15), for 19 weeks. ITT was determined at baseline and in the 19th week. HOMA-IR was determined between the 18-19th week in three different days and the mean was considered for analysis. Area under the curve (AUC-ITT) of the blood glucose excursion along 120 minutes after intra-peritoneal insulin injection was determined and correlated with the corresponding fasting values for HOMA-IR. Results AUC-ITT and HOMA-IR were significantly greater after 19th week in HFD compared to CD (p < 0.001 for both). AUC-OGTT was also higher in HFD rats (p = 0.003). HOMA-IR was strongly correlated (Pearson's) with AUC-ITT r = 0.637; p < 0.0001. ROC curves of HOMA-IR and AUC-ITT showed similar sensitivity and specificity. Conclusion HOMA-IR is a valid measure to determine insulin-resistance in Wistar rats. Arch Endocrinol Metab. 2016;60(2):138-42.
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The reduction in the HOMA index indicates glycemic control.
“The reduction in the HOMA index indicates glycemic control (76) and the increase in GLP-1 indicates control of hunger and possible protection of pancreatic beta cells, which are insulin-producing cells, essential for maintaining glycidic homeostasis (77).”
From Kefir and Intestinal Microbiota Modulation: Implications in Human Health (2021) · cites this paper as [76]
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Cites
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Use and Abuse of HOMA Modeling
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Haffner, S. M., Miettinen, H., & Stern, M. P. (1997) · Diabetes Care · doi:10.2337/diacare.20.7.1087 · Cited by 788
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Kefir and Intestinal Microbiota Modulation: Implications in Human Health
Peluzio, M. D. C. G., Dias, M. D. M. E., Martinez, J. A., & Milagro, F. I. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.638740 · Cited by 92
Metadata
- Authors
- Antunes, L. C., Elkfury, J. L., Jornada, M. N., Foletto, K. C., & Bertoluci, M. C.
- Affiliations
- Universidade Federal do Rio Grande do Sul, Brasil; , Brasil
- , Brasil; Universidade Federal do Rio Grande do Sul, Brasil
- Universidade Federal do Rio Grande do Sul (BR)
- Venue
- Archives of Endocrinology and Metabolism
- Published
- 2016-04
- Volume
- 60
- Issue
- 2
- Pages
- 138-142
- ISSN
- 2359-3997 (ISSN-L)
- OpenAlex
- W2385669856
- Cited by
- 247
- References
- 3
- Citations by year
- 2026: 13 · 2025: 20 · 2024: 25 · 2023: 35 · 2022: 30 · 2021: 37 · 2020: 28 · 2019: 36 · 2018: 11 · 2017: 8 · 2016: 4
- FWCI
- 19.80
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by
- Locations
- Archives of Endocrinology and Metabolism (publishedVersion, cc-by)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- Americanae (AECID Library) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Hospital de Clínicas de Porto Alegre
- Fundação Instituto de Pesquisas Econômicas
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Keywords
- HOMA-IR, insulin resistance, high-fat diet, insulin tolerance test, HOMA, Wistar rats, area under the curve, oral glucose tolerance test, ROC curve, sensitivity and specificity
- MeSH terms
- Animals, Blood Glucose, Body Weight, Fasting, Glucose Tolerance Test, Homeostasis, Insulin, Insulin Resistance, Male, Reference Standards, Sensitivity and Specificity, Time Factors, Reproducibility of Results, Rats, Wistar, Diet, High-Fat
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