Assessment of insulin sensitivity/resistance
Open accessAbstract
Insulin resistance is one pretty troublesome entity which very commonly aggravates metabolic syndrome. Many methods and indices are available for the estimation of insulin resistance. It is essential to test and validate their reliability before they can be used as an investigation in patients. At present, hyperinsulinemic euglycemic clamp and intravenous glucose tolerance test are the most reliable methods available for estimating insulin resistance and are being used as a reference standard. Some simple methods, from which indices can be derived, have been validated e.g. homeostasis model assessment (HOMA), quantitative insulin sensitivity check index (QUICKI). For the clinical uses HOMA-insulin resistance, QUIKI, and Matsuda are suitable, while HES, McAuley, Belfiore, Cederholm, Avignon and Stumvoll index are suitable for epidemiological/research purposes. With increasing number of these available indices of IR, it may be difficult for clinicians to select the most appropriate index for their studies. This review provides guidelines that must be considered before performing such studies.
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There is a lack of uniformity for estimating insulin sensitivity in type 1 diabetes.
“a lack of uniformity for estimating insulin sensitivity (IS) [3,4,5,6,7]”
From Menstrual Cycle, Glucose Control and Insulin Sensitivity in Type 1 Diabetes: A Systematic Review (2023) · cites this paper as [5]
The Introduction (page unavailable) describes multiple indices for estimating insulin sensitivity and says their clinical use is limited by a lack of reference values. That supports a general concern about uniform estimation, but the paper does not establish that this lack of uniformity applies specifically to type 1 diabetes. (LLM, conf=0.86)
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Cites
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“The homeostasis model assessment (HOMA-IR) and wholebody insulin sensitivity index (WBISI) calculations were performed to assess insulin resistance [19, 20].”
MethodAdelmeyer, J., Schauer, C. M., & Kann, P. H. (2024) · Hormones · doi:10.1007/s42000-024-00542-1 · Cited by 3 · see citing works
“Although use of the OGTT for diagnostic purposes has been criticized, it is a proven tool for determining insulin resistance and insulin secretion [45 – 47 ].”
- Authors
- Gutch, M., Kumar, S., Razi, S., Gupta, K., & Gupta, A.
- Affiliations
- Lala Lajpat Rai Memorial Medical College (IN)
- Sanjay Gandhi Post Graduate Institute of Medical Sciences (IN)
- Corresponding author
- Gutch, Manish
- ORCID
- Gutch, Manish
- Venue
- Indian Journal of Endocrinology and Metabolism
- Published
- 2015
- Volume
- 19
- Issue
- 1
- Pages
- 160
- ISSN
- 2230-8210 (ISSN-L)
- PMC
- PMC4287763
- OpenAlex
- W2091512839
- Cited by
- 555
- References
- 2
- Citations by year
- 2026: 27 · 2025: 51 · 2024: 83 · 2023: 77 · 2022: 70 · 2021: 80 · 2020: 57 · 2019: 51 · 2018: 34 · 2017: 16 · 2016: 8 · 2015: 1
- FWCI
- 6.71
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- Indian Journal of Endocrinology and Metabolism (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- insulin resistance, insulin sensitivity, insulin resistance index, HOMA-IR, QUICKI, Matsuda index, hyperinsulinemic-euglycemic clamp, intravenous glucose tolerance test, metabolic syndrome, index validation
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