CoChat
Sign Up
Cited by 315Liver Disease Diagnosis and TreatmentDiabetes, Cardiovascular Risks, and LipoproteinsDiet, Metabolism, and Disease

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

Insulin resistance index (HOMA-IR) in the differentiation of patients with non-alcoholic fatty liver disease and healthy individuals

Open access
Salgado, Ana Lúcia Farias de Azevedo, Carvalho, Luciana de, Oliveira, Ana Claudia, Santos, Virgínia Nascimento dos, Vieira, Jose Gilberto, Parise, Edison Roberto·2010·Arquivos de Gastroenterologia
DOI 10.1590/s0004-28032010000200009
Open this paper in CoChat — free accountOpen PDF

Abstract

CONTEXT: Due to its good correlation to glycemic clamp, HOMA-IR has been widely utilized as insulin resistance index in clinical and epidemiological studies involving non-alcoholic fatty liver disease carriers. However, values used for this parameter have shown large variability. OBJECTIVE: To identify the HOMA-IR cut value that best distinguishes non-diabetic non-alcoholic fatty liver disease patients from a control group. METHODS: One hundred sixteen non-alcoholic fatty liver disease patients were studied, diagnosed by clinical, biochemical, and liver image or biopsy criteria, and 88 healthy individuals, without any liver disease and testing for oral glucose tolerance within normality. These groups did not differ in age and gender. All were submitted to oral glucose tolerance test and blood samples were collected for glucose and insulin measurements by immunofluorometric method. HOMA-IR was calculated according to the formula: fasting insulin (µU/L) x fasting glucose (nmol/L)/22.5. RESULTS: NAFLD patients showed higher insulin, glycemia, and HOMA-IR values than control group, even when excluding glucose intolerant and diabetes mellitus patients by their glycemic curves. HOMA-IR 75th percentile for control group was 1.78 and the best area under the curve index was obtained for HOMA-IR values of 2.0 [AUC= 0.840 (0.781-0.899 CI 95%), sensitivity (Se): 85%, specificity (Sp): 83%] while value 2.5 showed best specificity without important loss in sensitivity [AUC=0,831 (0.773-0.888) Se = 72%, Sp = 94%]. CONCLUSION: HOMA-IR values above or equal to 2.0 or 2.5 show enhanced diagnostic value in distinguishing non-alcoholic fatty liver disease carriers from control group individuals.

Overview

Integrity signals

Registry

Crossref · 10.1590/s0004-28032010000200009

Cites

31 of 31 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 31 references

Cited by

Sorted by citations

Items 301–315 of 315

Related

See all

Metadata

Authors
Salgado, A. L. F. D. A., Carvalho, L. D., Oliveira, A. C., Santos, V. N. D., Vieira, J. G., & Parise, E. R.
Affiliations
  • Universidade Federal de São Paulo, Brazil
  • Universidade Federal de São Paulo (BR)
ORCID
Venue
Arquivos de Gastroenterologia
Publisher
FapUNIFESP (SciELO)
Published
2010-06
Volume
47
Issue
2
Pages
165-169
ISSN
0004-2803 (ISSN-L)
DOI
10.1590/s0004-28032010000200009
OpenAlex
W2156773567
Cited by
315
References
31
Citations by year
2026: 13 · 2025: 24 · 2024: 38 · 2023: 40 · 2022: 34 · 2021: 40 · 2020: 27 · 2019: 26 · 2018: 17 · 2017: 16 · 2016: 15 · 2015: 11 · 2014: 3 · 2013: 7 · 2012: 2
FWCI
2.56
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • Arquivos de Gastroenterologia (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
  • Americanae (AECID Library) (submittedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
Topics
  • Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Keywords
HOMA-IR, insulin resistance, non-alcoholic fatty liver disease, diagnostic thresholds, fasting insulin, fasting blood glucose, oral glucose tolerance test, diagnostic accuracy, non-diabetic patients
MeSH terms
Adult, Blood Glucose, Diagnosis, Differential, Fasting, Fatty Liver, Female, Homeostasis, Humans, Insulin Resistance, Male, Reference Values, Fluoroimmunoassay, Case-Control Studies

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review