Ferritina sérica e coronariopatia obstrutiva: correlação angiográfica
Open accessAbstract
OBJECTIVE: To verify the possible association between the levels of serum ferritin and the degree of obstructive coronary artery disease. METHODS: 115 patients with coronary arteriography and concomitant evaluation of serum ferritin were studied. The adopted cut-off values were 80 ng/ml for women and 120 ng/ml for men. RESULTS: The mean ferritin levels for males and females were 133.9 +/- 133.8 ng/ml and 214.6 +/- 217.2 ng/ml, respectively (p=0.047). It was observed that 44.1% of the women had normal serum ferritin levels in comparison to 30.9% of the men (p=0.254). In the patients without obstructive coronary artery disease or with less severe obstructions (group A) the serum ferritin level was 222.3 +/- 325 ng/ml. On the other hand, for those with moderate (group B) and severe obstructions (group C) the levels were 145.6+-83.7 ng/ml and 188.9 +/- 150.6 ng/ml, respectively. There was no correlation between the degree of coronary artery disease and the mean level of serum ferritin. Regarding the cut-off value, the number of women with serum ferritin level > 80 ng/ml in groups B+C or only C was significantly higher than the number of women in group A (ODDS RATIO 9.71 with 95%CI from 1.63 to 57.72). For males there was no significant difference between the number of cases above or below the cut-off values (ODDS RATIO 0.92 with 95%CI from 0.28 to 2.95). CONCLUSION: It was verified that women with serum ferritin levels > 80 ng/mL presented more severe obstructive coronary artery disease than women with lower levels. In men, the serum ferritin level was not a predictor element of the degree of obstruction.
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Kell, D. B. (2009) · BMC Medical Genomics · doi:10.1186/1755-8794-2-2 · Cited by 554 · see citing works
Kell, D. B. (2010) · Archives of Toxicology · doi:10.1007/s00204-010-0577-x · Cited by 361 · see citing works
- Authors
- Godoy, M. F. D., Takakura, I. T., Machado, R. D., Grassi, L. V., & Nogueira, P. R.
- Affiliations
- Faculdade de Medicina de São José do Rio Preto (BR)
- Venue
- Arquivos Brasileiros de Cardiologia
- Publisher
- FapUNIFESP (SciELO)
- Published
- 2007-04
- Volume
- 88
- Issue
- 4
- Pages
- 430-433
- ISSN
- 0066-782X (ISSN-L)
- OpenAlex
- W2047584036
- Cited by
- 15
- References
- 16
- Citations by year
- 2023: 1 · 2022: 1 · 2020: 1 · 2018: 1 · 2013: 1 · 2012: 1
- FWCI
- 1.06
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc
- Locations
- Arquivos Brasileiros de Cardiologia (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Keywords
- serum ferritin, obstructive coronary artery disease, coronary artery disease severity, sex differences, angiographic severity, cut-off values, biomarkers
- MeSH terms
- Adult, Aged, Aged, 80 and over, Coronary Artery Disease, Female, Ferritins, Humans, Male, Middle Aged, Reference Values, Severity of Illness Index, Sex Factors, Biomarkers, Odds Ratio, Coronary Angiography
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