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Antimicrobial activity in vitro of plumbagin isolated from Plumbago species
Open accessAbstract
Plumbagin is a naturally occurring naphthoquinone isolated from roots of Plumbago scandens. The plant was collected at the Campus of Fundação Oswaldo Cruz, Rio de Janeiro, Brazil. P. scandens is used as a traditional medicine for the treatment of several diseases. The antimicrobial activity of plumbagin was evaluated using the macrodilution method. The compound exhibited relatively specific activity against bacteria and yeast. The minimum inhibitory concentration test showed the growth inhibiton of Staphylococcus aureus at a concentration of 1.56 g/ml and of Candida albicans at a concentration of 0.78 g/ml. These results suggest the naphthoquinone plumbagin as a promising antimicrobial agent.
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Esquenazi, D., Wigg, M. D., Miranda, M. M. F. S., Rodrigues, H. M., Tostes, J. B. F., Rozental, S., da Silva, A. J. R., & Alviano, C. S. (2002) · Research in Microbiology · doi:10.1016/s0923-2508(02)01377-3 · Cited by 291
Cited by
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Imlay, J. A. (2019) · Environmental Microbiology · doi:10.1111/1462-2920.14445 · Cited by 313
Babula, P., Adam, V., Havel, L., & Kizek, R. (2009) · Current Pharmaceutical Analysis · doi:10.2174/157341209787314936 · Cited by 268
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Metadata
- Authors
- Paiva, S. R. D., Figueiredo, M. R., Aragão, T. V., & Kaplan, M. A. C.
- Venue
- Memórias do Instituto Oswaldo Cruz
- Publisher
- FapUNIFESP (SciELO)
- Published
- 2003-10
- Volume
- 98
- Issue
- 7
- Pages
- 959-961
- ISSN
- 0074-0276 (ISSN-L)
- OpenAlex
- W2111328511
- Cited by
- 188
- References
- 1
- FWCI
- 1.60
- Type
- journal article
- Language
- en
- Open access
- diamond
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- Paiva, S. R. D., Figueiredo, M. R., Aragão, T. V., & Kaplan, M. A. C. (2003). Antimicrobial activity in vitro of plumbagin isolated from Plumbago species. Memórias do Instituto Oswaldo Cruz. https://doi.org/10.1590/s0074-02762003000700017
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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