Antimicrobial and antiviral activities of polyphenolics from Cocos nucifera Linn. (Palmae) husk fiber extract
Open accessAbstract
The decoction of Cocos nucifera L. husk fiber has been used in northeastern Brazil traditional medicine for treatment of diarrhea and arthritis. Water extract obtained from coconut husk fiber and fractions from adsorption chromatography revealed antimicrobial activity against Staphylococcus aureus. The crude extract and one of the fractions rich in catechin also showed inhibitory activity against acyclovir-resistant herpes simplex virus type 1 (HSV-1-ACVr). All fractions were inactive against the fungi Candida albicans, Fonsecaea pedrosoi and Cryptococcus neoformans. Catechin and epicatechin together with condensed tannins (B-type procyanidins) were demonstrated to be the components of the water extract.
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Monolaurin exhibits antiviral and antifungal activity.
“Cellular studies have also shown that monolaurin exhibits antiviral and antifungal activity [78].”
From Anti-Inflammatory and Skin Barrier Repair Effects of Topical Application of Some Plant Oils (2017) · cites this paper as [78]
Meneguetti et al. (2017) and Esquenazi et al. (2002) reported the presence of several phenolic compounds in coconut including Catechin and salicylic acid in the CW and gallic, caffeic, salicylic, and p-coumaric acids in the meat.
“Meneguetti et al. (2017) and Esquenazi et al. (2002) reported the presence of several phenolic compounds in coconut including Catechin and salicylic acid in the CW and gallic, caffeic, salicylic, and p-coumaric acids in the meat.”
From The use of High-Pressure Processing (HPP) to improve the safety and quality of raw coconut (Cocos nucifera L) water (2020) · cites this paper as Esquenazi et al. (2002)
Others have reported antiviral and antibacterial activities in coconut due to lauric acid and other antimicrobial components.
“Others have reported antiviral and antibacterial activities due to the presence of lauric acid and other antimicrobial components (Cruz et al., 2014;Esquenazi et al., 2002;Meneguetti et al., 2017;Sarika and Rai, 2012;Sheri et al., 2006).”
From The use of High-Pressure Processing (HPP) to improve the safety and quality of raw coconut (Cocos nucifera L) water (2020) · cites this paper as Esquenazi et al., 2002
In Brazil, extract from the husk fiber of C. nucifera is used to treat diarrhea.
“In Brazil, extract from the husk fiber of C. nucifera is used to treat diarrhea (7).”
From Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review (2015) · cites this paper as [7]
The antifungal, antimicrobial, and antiviral effects were attributed to condensed tannins and catechins present in the crude extract and fractions II-V, especially fraction II.
“The antifungal, antimicrobial, and antiviral effects were attributed to condensed tannins and catechins present in the crude extract and fractions II-V, especially fraction II, which had a higher concentration of these compounds.”
From Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review (2015) · cites this paper as [7]
Antiviral action was only seen with the crude extract and fraction II.
“Antiviral action was only seen with the crude extract and fraction II.”
From Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review (2015) · cites this paper as [7]
Antifungal activity was demonstrated as growth inhibition of Candida albicans, Cryptococcus neoformans or Fonsecaea pedrosoi.
“Antifungal activity was demonstrated as growth inhibition of Candida albicans, Cryptococcus neoformans or Fonsecaea pedrosoi.”
From Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review (2015) · cites this paper as [7]
The lyophilized extract and fractions, as well as ethyl acetate extracts, from the C. nucifera fiber are rich in polyphenols, compounds such as catechins, epicatechins, tannins, and flavonoids.
“The lyophilized extract and fractions, as well as ethyl acetate extracts, from the C. nucifera fiber are rich in polyphenols, compounds such as catechins, epicatechins, tannins, and flavonoids (7,33–35).”
From Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review (2015) · cites this paper as [7]
In studies with crude extract and five TLC fractions (I-V) of fiber mesocarp, in vitro antimicrobial activity was seen in all trial strains of S. aureus tested with fractions II-V.
“In studies with crude extract and five TLC fractions (I-V) of fiber mesocarp of C. nucifera fruit, in vitro antimicrobial activity was seen in all trial strains of S. aureus tested with fractions II-V (7).”
From Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review (2015) · cites this paper as [7]
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- Authors
- Esquenazi, D., Wigg, M. D., Miranda, M. M. F. S., Rodrigues, H. M., Tostes, J. B. F., Rozental, S., da Silva, A. J. R., & Alviano, C. S.
- Affiliations
- Universidade Federal do Rio de Janeiro (BR)
- Corresponding author
- Esquenazi, Daniele
- ORCID
- Alviano, Celuta S.
- Venue
- Research in Microbiology
- Publisher
- Elsevier BV
- Published
- 2002-12
- Volume
- 153
- Issue
- 10
- Pages
- 647-652
- ISSN
- 0769-2609 (ISSN-L)
- 0923-2508
- OpenAlex
- W2073056737
- Cited by
- 291
- References
- 36
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 7 · 2023: 20 · 2022: 19 · 2021: 18 · 2020: 17 · 2019: 17 · 2018: 18 · 2017: 9 · 2016: 18 · 2015: 16 · 2014: 7 · 2013: 15 · 2012: 17
- FWCI
- 2.14
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Research in Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Inorganic Chemistry › Coconut Research and Applications
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Keywords
- Cocos nucifera, coconut husk fiber, polyphenols, catechins, epicatechin, procyanidins, proanthocyanidins, antimicrobial activity, antiviral activity, Staphylococcus aureus, herpes simplex virus type 1, acyclovir resistance, Candida albicans, Fonsecaea pedrosoi, Cryptococcus neoformans, traditional medicine, decoction
- MeSH terms
- Animals, Anti-Infective Agents, Anti-Bacterial Agents, Antiviral Agents, Catechin, Chlorocebus aethiops, Chromatography, High Pressure Liquid, Cocos, Flavonoids, Humans, Phenols, Plant Extracts, Polymers, Staphylococcus aureus, Vero Cells, Herpesvirus 1, Human
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