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Cited by 108Animal Vocal Communication and BehaviorMemory and Neural MechanismsStress Responses and Cortisol

On the relationships between ultrasonic calling and anxiety-related behavior in rats

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Schwarting, R.K.W., Wöhr, M.·2012·Brazilian Journal of Medical and Biological Research
DOI 10.1590/s0100-879x2012007500038PMC PMC3854164
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Abstract

In the present review, the phenomenon of ultrasonic vocalization in rats will be outlined, including the three classes of vocalizations, namely 40-kHz calls of pups, and 22- and 50-kHz calls of juvenile and adult rats, their general relevance to behavioral neuroscience, and their special relevance to research on anxiety, fear, and defense mechanisms. Here, the emphasis will be placed on 40- and 22-kHz calls, since they are typical for various situations with aversive properties. Among other topics, we will discuss whether such behavioral signals can index a certain affective state, and how these signals can be used in social neuroscience, especially with respect to communication. Furthermore, we will address the phenomenon of inter-individual variability in ultrasonic calling and what we currently know about the mechanisms, which may determine such variability. Finally, we will address the current knowledge on the neural and pharmacological mechanisms underlying 22-kHz ultrasonic vocalization, which show a substantial overlap with mechanisms known from other research on fear and anxiety, such as those involving the periaqueductal gray or the amygdala.

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  • Rat ultrasonic vocalizations can be categorized into two main groups: positive/"happy" 50 kHz USVs and negative/"distress" 22 kHz USVs.

    “USVs in rats can be categorized into 2 main groups: positive/“happy” 50 kHz USVs and negative/“distress” 22 kHz USVs.7-9,24,33,38,39,41”

    From Ultrasonic Vocalization Analysis as a Novel Metric to Assess Cage Enrichment in Rats (2022) · cites this paper as [41]

    The Introduction identifies 50-kHz calls with appetitive behavior and 22-kHz calls with aversion, supporting the positive/negative distinction. But it explicitly defines three classes—40-, 22-, and 50-kHz calls—not the two main groups stated in the claim. (LLM, conf=0.92)

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Authors
Schwarting, R. K. W., & Wöhr, M.
Affiliations
Philipps University of Marburg (DE)
ORCID
Venue
Brazilian Journal of Medical and Biological Research
Publisher
FapUNIFESP (SciELO)
Published
2012-04
Volume
45
Issue
4
Pages
337-348
ISSN
0100-879X (ISSN-L)
DOI
10.1590/s0100-879x2012007500038
PMC
PMC3854164
OpenAlex
W2157132268
Cited by
108
References
1
Citations by year
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FWCI
4.22
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • Brazilian Journal of Medical and Biological Research (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
  • Americanae (AECID Library) (submittedVersion, cc-by-nc)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • Deutscher Akademischer Austauschdienst
  • Deutsche Forschungsgemeinschaft
  • Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Developmental Biology › Animal Vocal Communication and Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
ultrasonic vocalizations, anxiety, fear, defense mechanisms, 22-kHz calls, 50-kHz calls, interindividual variability, social communication, periaqueductal gray, amygdala, pharmacological mechanisms, rats
MeSH terms
Acoustic Stimulation, Age Factors, Animals, Anxiety, Fear, Male, Vocalization, Animal, Rats, Wistar, Rats

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