Positive and negative ultrasonic social signals elicit opposing firing patterns in rat amygdala

Parsana, Ashwini J.; Li, Nanxin; Brown, Thomas H.

doi:10.1016/j.bbr.2011.08.040

Cited by 109Memory and Neural MechanismsAnimal Vocal Communication and BehaviorNeuroscience and Music Perception

Positive and negative ultrasonic social signals elicit opposing firing patterns in rat amygdala

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Parsana, Ashwini J., Li, Nanxin, Brown, Thomas H.·2012·Behavioural Brain Research

DOI 10.1016/j.bbr.2011.08.040PMC PMC3197767

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Abstract

Rat ultrasonic vocalizations (USVs) are ethologically-essential social signals. Under natural conditions, 22kHz USVs and 50kHz USVs are emitted in association with negative and positive emotional states, respectively. Our first experiment examined freezing behavior elicited in naïve Sprague-Dawley rats by a 22kHz USV, a 50kHz USV, and frequency-matched tones. None of the stimuli elicited freezing, which is the most commonly-used index of fear. The second experiment examined single-unit responses to these stimuli in the amygdala (AM), which is well-known for its role in innate and acquired fear responses. Among 127 well-discriminated single units, 82% were auditory-responsive. Elicited firing patterns were classified using a multi-dimensional scheme that included transient (phasic) responses to the stimulus onsets and/or offsets as well as sustained (tonic) responses during the stimulus. Tonic responses, which are not ordinarily evaluated in AM, were 4.4-times more common than phasic responses. The 22kHz stimuli tended to elicit tonic increases in the firing rates, whereas the 50kHz stimuli more often elicited tonic decreases in firing rates. These opposing tonic responses correspond with the ethological valence of USVs in the two frequency bands. Thus, a relatively-small sample of single-unit responses in AM furnished a more sensitive index of emotional valence than freezing behavior. Latency analysis suggested that stimuli in the two frequency bands are processed through different pathways to AM. One possible interpretation is that phasic responses in AM reflect the detection of a stimulus change, whereas tonic responses indicate the valence of the detected stimulus.

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Rat ultrasonic vocalizations can be categorized into two main groups: positive/"happy" 50 kHz USVs and negative/"distress" 22 kHz USVs.
“USVs in rats can be categorized into 2 main groups: positive/“happy” 50 kHz USVs and negative/“distress” 22 kHz USVs.7-9,24,33,38,39,41”
From Ultrasonic Vocalization Analysis as a Novel Metric to Assess Cage Enrichment in Rats (2022) · cites this paper as [33]
Ultrasonic vocalizations are a sensitive method of assessing rodent communication and affective state.
“Ultrasonic vocalizations (USVs) are a sensitive method of assessing rodent communication and affective state9,33”
From Ultrasonic Vocalization Analysis as a Novel Metric to Assess Cage Enrichment in Rats (2022) · cites this paper as [33]

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Authors: Parsana, A. J., Li, N., & Brown, T. H.
Affiliations: Yale University (US)
Corresponding author: Brown, Thomas H.
ORCID: Li, Nanxin
Brown, Thomas H.
Venue: Behavioural Brain Research
Publisher: Elsevier BV
Published: 2012-01
Volume: 226
Issue: 1
Pages: 77-86
ISSN: 0166-4328 (ISSN-L)
DOI: 10.1016/j.bbr.2011.08.040
PMC: PMC3197767
OpenAlex: W2150062107
Cited by: 108
References: 78
Citations by year: 2026: 2 · 2025: 4 · 2024: 5 · 2023: 9 · 2022: 7 · 2021: 8 · 2020: 8 · 2019: 4 · 2018: 10 · 2017: 8 · 2016: 12 · 2015: 7 · 2014: 6 · 2013: 10 · 2012: 8
FWCI: 3.90
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Behavioural Brain Research (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (R01MH058405)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Developmental Biology › Animal Vocal Communication and Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neuroscience and Music Perception
Keywords: ultrasonic vocalizations, social signals, amygdala, single-unit responses, emotional valence, freezing behavior, fear, auditory processing, rats
MeSH terms: Acoustic Stimulation, Amygdala, Animals, Behavior, Animal, Fear, Male, Neurons, Social Behavior, Vocalization, Animal, Rats, Sprague-Dawley, Freezing Reaction, Cataleptic, Rats

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Positive and negative ultrasonic social signals elicit opposing firing patterns in rat amygdala

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