An experimental study on the preventive effects of N-acetyl cysteine and ozone treatment against contrast-induced nephropathy
Open accessAbstract
PURPOSE: To compare the preventive effects of N-acetyl cysteine (NAC), ozone preconditioning and ozone treatment against contrast-induced nephropathy (CIN) in an experimental rat model. METHODS: Thirty adult male Wistar rats were randomly distributed into five groups (n=6 for each group). Group I served as control and Group II had only contrast agent, while Group III received NAC and Group IV received intraperitoneal ozone 6 hours before and 6 hours after introduction of contrast agent. Ozone treatment was applied for 5 days after the contrast agent was introduced in Group V. After induction of CIN, groups were compared in terms of serum levels of urea, creatinine, neutrophil gelatinase associated lipocalin, protein carbonyl, total antioxidant capacity (TAC) as well as degree of renal injury at histopathologic level. RESULTS: Groups II-V displayed more obvious histopathological alterations such as hemorrhage and renal tubular injury compared with Group I. TAC (p=0.043) and creatinine (p=0.046) levels increased significantly in Group II after the intervention. In Group III, protein carbonyl level diminished remarkably (p=0.046), while creatinine level was increased (p=0.046) following the intervention. TAC level was higher in Group IV (p=0.028) and Group V (p=0.026) following the procedure. CONCLUSION: The N-acetyl cysteine and ozone treatment may alleviate the biochemical and histopathological deleterious effects of contrast-induced nephropathy via enhancement of total antioxidant capacity and decreasing oxidative stress.
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N-acetyl cysteine prevents acute kidney injury as documented by reduced biomarkers of oxidative stress and inflammation and increased antioxidant biomarkers.
“N-acetyl cysteine was able to prevent acute kidney injury (acute renal failure) as documented by reduced biomarkers of oxidative stress and inflammation and increased antioxidant biomarkers (Ozturk et al. 2018).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Ozturk et al. 2018
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Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging
Jomova, K., Raptova, R., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03562-9 · Cited by 2,638 · see citing works
- Authors
- Ozturk, O., Eroglu, H. A., Ustebay, S., Kuzucu, M., & Adali, Y.
- Affiliations
- Canakkale Onsekiz Mart University, Turkey
- Kafkas University, Turkey
- Erzincan Binali Yıldırım University (TR)
- ORCID
- Kuzucu, Mehmet
- Venue
- Acta Cirurgica Brasileira
- Publisher
- FapUNIFESP (SciELO)
- Published
- 2018-06
- Volume
- 33
- Issue
- 6
- Pages
- 508-517
- ISSN
- 0102-8650 (ISSN-L)
- 1678-2674
- OpenAlex
- W2884758791
- Cited by
- 17
- References
- 27
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 1
- FWCI
- 1.65
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Acta Cirúrgica Brasileira (publishedVersion, cc-by)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- Çanakkale Onsekiz Mart University AVESIS (submittedVersion)
- Americanae (AECID Library) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
- Health Sciences › Medicine › Pathology and Forensic Medicine › Chemotherapy-induced organ toxicity mitigation
- Health Sciences › Medicine › Pharmacology › Medical and Biological Ozone Research
- Keywords
- contrast-induced nephropathy, N-acetylcysteine, ozone therapy, renal protection, oxidative stress, total antioxidant capacity, protein carbonyls, neutrophil gelatinase-associated lipocalin, contrast media nephrotoxicity, kidney histopathology
- MeSH terms
- Lipocalin-2, Acetylcysteine, Animals, Antioxidants, Contrast Media, Creatinine, Ioxaglic Acid, Kidney, Kidney Diseases, Male, Ozone, Random Allocation, Reference Values, Spectrophotometry, Urea, Reproducibility of Results, Treatment Outcome, Rats, Wistar, Oxidative Stress, Protein Carbonylation
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