Influence of glycerol and ornithine feeding on clavulanic acid production by Streptomyces clavuligerus
Open accessAbstract
The influence of glycerol and ornithine feeding on clavulanic acid (CA) production by Streptomyces clavuligerus was investigated. In batch experiments, CA maximum concentration (Cp max) ranged randomly from 430 to 560 mg.L-1, with a maximum increase of 10% in relation to the control run, without ornithine. However, the maximum volumetric productivity of CA (Pp max) of 13.7 mg.L-1.h-1 was obtained with 0.66 g.L-1 of ornithine, 44.2% higher than the Pp max in the control run. In fed-batch experiments, Cp max varied within the narrow range from 1.254 to 1.405 g.L-1, 2.5 times higher than that obtained in the control run. The presence of ornithine increased the Pp max, although it influenced only slightly the Cp max. Concerning glycerol, the highest CA production of 1.6 g.L-1 was obtained in the fed-batch with glycerol and ornithine (180 and 3.7 g.L−1) in a 10-L bioreactor, showing a positive effect of ornithine and glycerol, in the proper proportion (48.6:1), on CA biosynthesis.
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Teodoro et al. (2010) revealed an insignificant difference in maximum clavulanic acid concentration when the feeding media was replaced with distilled water containing only glycerol and ornithine at the same concentrations as the production media.
“Interestingly, the same study also revealed an insignificant difference in maximum clavulanic acid concentration when the feeding media (which possesses the same composition as the production media) was replaced with distilled water containing only glycerol and ornithine (at same concentrations as the production media).”
From Fermentation Conditions that Affect Clavulanic Acid Production in Streptomyces clavuligerus: A Systematic Review (2016) · cites this paper as Teodoro et al. (2010)
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Experimental — accuracy not yet measuredTeodoro et al. (2010) did not find any significant changes in maximum clavulanic acid production due to ornithine, regardless of batch or fed-batch fermentation systems.
“The study did not find any significant changes in maximum clavulanic acid production due to ornithine, regardless of batch or fed-batch fermentation systems.”
From Fermentation Conditions that Affect Clavulanic Acid Production in Streptomyces clavuligerus: A Systematic Review (2016) · cites this paper as Teodoro et al. (2010)
Only three studies reported the effect of amino acid in fed-batch fermentation.
“Only three studies reported the effect of amino acid in fed-batch fermentation (Chen et al., 2003; Saudagar and Singhal, 2007b; Teodoro et al., 2010);”
From Fermentation Conditions that Affect Clavulanic Acid Production in Streptomyces clavuligerus: A Systematic Review (2016) · cites this paper as Teodoro et al., 2010
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Research works printed but not linked: 1
- Wang, Y. H., Yang, B., Ren, J., Dong, M. L., Liang, D., Xu, A. L., Optimization of medium composition for the production of clavulanic acid by Streptomyces clavuligerus. Proc. Biochem., 40, 1161-1166 (2005).
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Ser, H.-L., Law, J. W.-F., Chaiyakunapruk, N., Jacob, S. A., Palanisamy, U. D., Chan, K.-G., Goh, B.-H., & Lee, L.-H. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00522 · Cited by 90 · see citing works
Degradation Kinetics of Clavulanic Acid in Fermentation Broths at Low Temperatures
Gómez-Ríos, D., Ramírez-Malule, H., Neubauer, P., Junne, S., & Ríos-Estepa, R. (2019) · Antibiotics · doi:10.3390/antibiotics8010006 · Cited by 17 · see citing works
- Authors
- Teodoro, J. C., Baptista-Neto, A., Araujo, M. L. G. C., Hokka, C. O., & Badino, A. C.
- Affiliations
- Universidade Federal de São Carlos (BR)
- Federal University of São Carlos, Brazil
- Universidade Estadual Paulista (Unesp) (BR)
- Venue
- Brazilian Journal of Chemical Engineering
- Publisher
- FapUNIFESP (SciELO)
- Published
- 2010-12
- Volume
- 27
- Issue
- 4
- Pages
- 499-506
- ISSN
- 0104-6632 (ISSN-L)
- OpenAlex
- W2096993692
- Cited by
- 28
- References
- 0
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 4 · 2019: 3 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 3 · 2014: 1 · 2013: 3 · 2012: 2
- FWCI
- 1.18
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- Brazilian Journal of Chemical Engineering (publishedVersion, cc-by-nc)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- Acervo Digital da Universidade Estadual Paulista (Universidade Estadual Paulista) (submittedVersion, other-oa)
- Americanae (AECID Library) (submittedVersion, other-oa)
- Americanae (AECID Library) (submittedVersion, cc-by-nc)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo (03/11722-5, 05/55079-4)
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Topics
- Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Enzyme Production and Characterization
- Keywords
- clavulanic acid, Streptomyces clavuligerus, glycerol feeding, fed-batch fermentation, volumetric productivity, antibiotic biosynthesis, carbon source supplementation
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