Instituto Nacional de Ciência e Tecnologia em Medicina Translacional (INCT-TM): abordagens metodológicas
Open accessAbstract
OBJETIVO: Medicina translacional pode ser descrita como a aplicação integrada de ferramentas farmacológicas inovadoras, biomarcadores, métodos e tecnologias clínicas e delineamentos de pesquisa para aumentar o conhecimento a respeito das doenças. A pesquisa translacional oferece uma oportunidade para aplicar os achados de pesquisa básica na clínica cotidiana. O Instituto Nacional de Ciência e Tecnologia - Medicina Translacional foi criado com seis centros (Universidade Federal do Rio Grande do Sul, Universidade de São Paulo-Ribeirão Preto, Universidade Federal do Rio de Janeiro, Pontifícia Universidade Católica do Rio Grande do Sul, Universidade Estadual de Santa Catarina e uma core facility que serve a todos os centros). Os objetivos deste projeto são divididos em quatro dimensões: institucional, pesquisa, formação de recursos humanos e transferência de tecnologia para a comunidade e setor produtivo. MÉTODO: Neste artigo, são apresentadas algumas das estratégias utilizadas para atingir os objetivos do Instituto Nacional de Ciência e Tecnologia - Medicina Translacional: 1) Desenvolvimento de modelos animais para o transtorno bipolar; 2) Estratégias de investigação neurocomportamental e disfunções cognitivas dos transtornos cerebrais; 3) Modelos experimentais de funcionamento cerebral e comportamento, proliferação celular e câncer; 4)Teste de Simulação de Falar em Público e 5) Realidade Virtual para indução de Pânico e Agorafobia. CONCLUSÃO: O Instituto Nacional de Ciência e Tecnologia - Medicina Translacional possui como foco principal o desenvolvimento de metodologias mais úteis para aumentar a aplicabilidade dos conhecimentos da pesquisa básica em medicina.
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The SPST used was the same as used by McNair et al (1982) with some modifications.
“The SPST was the same as used by McNair et al (1982) with some modifications (Hallak et al, 2010).”
From Cannabidiol Reduces the Anxiety Induced by Simulated Public Speaking in Treatment-Naïve Social Phobia Patients (2011) · cites this paper as Hallak et al, 2010
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Belmaker, R. H. (2004) · New England Journal of Medicine · doi:10.1056/nejmra035354 · Cited by 473 · see citing works
Effects of Group Experiential Cognitive Therapy for the Treatment of Panic Disorder with Agoraphobia
Choi, Y.-H., Vincelli, F., Riva, G., Wiederhold, B. K., Lee, J.-H., & Park, K.-H. (2005) · CyberPsychology & Behavior · doi:10.1089/cpb.2005.8.387 · Cited by 74 · see citing works
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Bergamaschi, M. M., Queiroz, R. H. C., Chagas, M. H. N., de Oliveira, D. C. G., De Martinis, B. S., Kapczinski, F., Quevedo, J., Roesler, R., Schröder, N., Nardi, A. E., et al. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.6 · Cited by 771 · see citing works
Self-citationCrippa, J. A. S., Derenusson, G. N., Ferrari, T. B., Wichert-Ana, L., Duran, F. L., Martin-Santos, R., Simões, M. V., Bhattacharyya, S., Fusar-Poli, P., Atakan, Z., et al. (2011) · Journal of Psychopharmacology · doi:10.1177/0269881110379283 · Cited by 535 · see citing works
Self-citationTranslational investigation of the therapeutic potential of Cannabidiol (CBD): Toward a new age
Crippa, J. A., Guimarães, F. S., Campos, A. C., & Zuardi, A. W. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02009 · Cited by 308 · see citing works
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- Authors
- Hallak, J. E. C., Crippa, J. A. S., Quevedo, J., Roesler, R., Schröder, N., Nardi, A. E., & Kapczinski, F.
- Affiliations
- Universidade de São Paulo (BR)
- Instituto Nacional de Ciência e Tecnologia Translacional em Medicina (BR)
- Universidade Federal do Rio Grande do Sul (BR)
- National Science and Technology Institute (INCT) for Translational Medicine; Universidade Federal do Rio de Janeiro, Brazil
- Corresponding author
- Hallak, Jaime E. C.
- Venue
- Revista Brasileira de Psiquiatria
- Publisher
- EDITORA SCIENTIFIC
- Published
- 2010-03
- Volume
- 32
- Issue
- 1
- Pages
- 83-90
- ISSN
- 1516-4446 (ISSN-L)
- OpenAlex
- W2160332447
- Cited by
- 15
- References
- 2
- Citations by year
- 2024: 1 · 2018: 1 · 2015: 1 · 2013: 3 · 2012: 3
- FWCI
- 3.80
- Type
- journal article
- Language
- pt
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc
- Locations
- Brazilian Journal of Psychiatry (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (acceptedVersion, other-oa)
- Americanae (AECID Library) (submittedVersion, cc-by-nc)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Health and Medical Research Impacts
- Health Sciences › Veterinary › Small Animals › Animal testing and alternatives
- Health Sciences › Medicine › Reproductive Medicine › Science, Research, and Medicine
- Keywords
- translational medicine, neurobehavioral function, cognitive impairment, brain disorders, neuropsychiatric disorders, cancer, virtual reality, panic disorder, agoraphobia, biomarkers
- MeSH terms
- Academies and Institutes, Animals, Brazil, Clinical Protocols, Disease Models, Animal, Health Systems Agencies, Humans, Mental Health, Organizational Innovation, Research Design, Medical Laboratory Science, Translational Research, Biomedical
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