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Interaction between human mucins and parasite glycoproteins: the role of lectins and glycosidases in colonization by intestinal protozoa

Martínez-Ocaña, Joel, Maravilla, Pablo, Olivo-Díaz, Angélica·2020·Revista do Instituto de Medicina Tropical de São Paulo
DOI 10.1590/s1678-9946202062064PMC PMC7477959
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Figure 1 Schematic representation of the interactions between the main protozoa intestinal pathogens and the human intestinal mucosa. In Giardia, lectin-like structures have been identified on the surface of the parasite, including GlcNAc, mannose and sialic acid as main components that can also be excreted/secreted by the parasite. E. histolytica and Cryptosporidium spp. express specific Gal/GalNAc (named gp30 in cryptosporidium) lectins that facilitate cell adhesion. In addition, Cryptosporidium gp40/15, gp900 and a CpClec lectin-like glycoprotein have been I described and are involved in adhesion to intestinal cells, forming an adhesion-attack complex. G. lamblia and Entamoeba hystolytica can also produce glycosidases such as: β-N-acetyl-D-glucosaminidase, α-d-glucosidase, β-d-galactosidase, β-l-fucosidase, α-N-acetyl-d-galactosaminidase and β-mannosidase. In Blastocystis, α-D-mannose, α-D-glucose, GlcNAc, α-D-Fucose, chitin and sialic acid have been identified on the surface of the parasite. Fucosidases, hexosaminidases and polygalacturonases, which may be involved in the mucin degradation process, have also been described in the predicted Blastocystis secretoma.
Figure 1 Schematic representation of the interactions between the main protozoa intestinal pathogens and the human intestinal mucosa. In Giardia, lectin-like structures have been identified on the surface of the parasite, including GlcNAc, mannose and sialic acid as main components that can also be excreted/secreted by the parasite. E. histolytica and Cryptosporidium spp. express specific Gal/GalNAc (named gp30 in cryptosporidium) lectins that facilitate cell adhesion. In addition, Cryptosporidium gp40/15, gp900 and a CpClec lectin-like glycoprotein have been I described and are involved in adhesion to intestinal cells, forming an adhesion-attack complex. G. lamblia and Entamoeba hystolytica can also produce glycosidases such as: β-N-acetyl-D-glucosaminidase, α-d-glucosidase, β-d-galactosidase, β-l-fucosidase, α-N-acetyl-d-galactosaminidase and β-mannosidase. In Blastocystis, α-D-mannose, α-D-glucose, GlcNAc, α-D-Fucose, chitin and sialic acid have been identified on the surface of the parasite. Fucosidases, hexosaminidases and polygalacturonases, which may be involved in the mucin degradation process, have also been described in the predicted Blastocystis secretoma.CC BY-NC · PubMed Central

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Authors
Martínez-Ocaña, J., Maravilla, P., & Olivo-Díaz, A.
Venue
Revista do Instituto de Medicina Tropical de São Paulo
Publisher
FapUNIFESP (SciELO)
Published
2020
Volume
62
ISSN
1678-9946
DOI
10.1590/s1678-9946202062064
PMC
PMC7477959
Cited by
16
References
1
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