Cited by 100Salivary Gland Disorders and FunctionsHIV/AIDS oral health manifestationsClinical Laboratory Practices and Quality Control

Salivary IgA and IgE levels in healthy subjects: Relation to age and gender

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Jafarzadeh, Abdollah, Sadeghi, Mostafa, Karam, Gholamreza Asadi, Vazirinejad, Reza·2010·Brazilian Oral Research

Abstract

It has been reported that the immune system undergoes age and gender changes. The aim of this study was to investigate the age- and gender-dependent changes of salivary IgA and IgE levels among healthy subjects. A total of 203 healthy individuals (aged 1-70 years) were enrolled in the study. Two milliliters of saliva were collected from all participants, and salivary IgA and IgE levels were measured by the ELISA technique. Mean salivary IgA levels were significantly higher in subjects aged 11-20 years as compared to subjects aged 1-10 years (P < 0.01). Mean salivary IgA levels increased with age up to the age of 60 years, and then slightly decreased in subjects aged 61-70 years. The frequency of subjects with detectable levels of salivary IgE and mean salivary IgE levels gradually increased with age, with maximum levels being observed in the 31-40 years age group and not changing significantly thereafter. The mean levels of salivary IgA and IgE in adults were significantly higher than those observed in children (P < 0.00001 and P < 0.05, respectively). No significant differences were observed between men and women regarding both salivary immunoglobulins. These results showed age-dependent changes of the salivary IgA and IgE levels. Gender had no effect on the salivary levels of IgA and IgE.

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  1. Sadeghnejad A, Karmaus W, Hasan Arshad S, Ewart S. IL-13 gene polymorphism association with cord serum immuno- globulin E. Pediatr Allergy Immunol. 2007;18(4):288-92.

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Authors
Jafarzadeh, A., Sadeghi, M., Karam, G. A., & Vazirinejad, R.
Affiliations
  • Rafsanjan University of Medical Sciences (IR)
  • Rafsanjan University of Medical Sciences, Iran
Venue
Brazilian Oral Research
Published
2010-03
Volume
24
Issue
1
Pages
21-27
ISSN
  • 1517-7491 (ISSN-L)
  • 1806-8324
OpenAlex
W2143032791
Cited by
100
References
18
Citations by year
2026: 2 · 2025: 6 · 2024: 7 · 2023: 13 · 2022: 9 · 2021: 10 · 2020: 9 · 2019: 2 · 2018: 8 · 2017: 4 · 2016: 6 · 2015: 10 · 2014: 5 · 2013: 6 · 2012: 2
FWCI
1.95
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • Brazilian Oral Research (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
  • Americanae (AECID Library) (submittedVersion, cc-by-nc)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Physiology › Salivary Gland Disorders and Functions
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › HIV/AIDS oral health manifestations
  • Health Sciences › Medicine › Physiology › Clinical Laboratory Practices and Quality Control
Keywords
salivary IgA, age-related changes, sex differences, salivary immunoglobulins, healthy volunteers, immunosenescence
MeSH terms
Adolescent, Adult, Age Factors, Aged, Child, Child, Preschool, Enzyme-Linked Immunosorbent Assay, Epidemiologic Methods, Female, Humans, Immunoglobulin A, Immunoglobulins, Immunologic Factors, Infant, Male, Middle Aged, Saliva, Sex Factors, Young Adult

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