Salivary IgA and IgE levels in healthy subjects: Relation to age and gender
Open accessAbstract
It has been reported that the immune system undergoes age and gender changes. The aim of this study was to investigate the age- and gender-dependent changes of salivary IgA and IgE levels among healthy subjects. A total of 203 healthy individuals (aged 1-70 years) were enrolled in the study. Two milliliters of saliva were collected from all participants, and salivary IgA and IgE levels were measured by the ELISA technique. Mean salivary IgA levels were significantly higher in subjects aged 11-20 years as compared to subjects aged 1-10 years (P < 0.01). Mean salivary IgA levels increased with age up to the age of 60 years, and then slightly decreased in subjects aged 61-70 years. The frequency of subjects with detectable levels of salivary IgE and mean salivary IgE levels gradually increased with age, with maximum levels being observed in the 31-40 years age group and not changing significantly thereafter. The mean levels of salivary IgA and IgE in adults were significantly higher than those observed in children (P < 0.00001 and P < 0.05, respectively). No significant differences were observed between men and women regarding both salivary immunoglobulins. These results showed age-dependent changes of the salivary IgA and IgE levels. Gender had no effect on the salivary levels of IgA and IgE.
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After 60 years of age, there is a decrease in secretory IgA, which forms part of the first line of defense against pathogens that invade mucosal surfaces.
“After 60 years of age, there is a decrease in secretory IgA, which forms part of the first line of defense against pathogens that manage to invade the mucosal surfaces [38].”
From Immune function and micronutrient requirements change over the life course (2018) · cites this paper as [38]
Salivary IgA levels increased only for the synbiotic group (2% at T28 and 8% at T56 with respect to baseline, not significant), in line with levels registered in elderly people.
“Considering the salivary IgA values (Figure 13), the levels increased only for the synbiotic group (2% at T28 and 8% at T56 with respect to the beginning of the study, not in a significant manner), in line with the levels registered in elderly people [47].”
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- Authors
- Jafarzadeh, A., Sadeghi, M., Karam, G. A., & Vazirinejad, R.
- Affiliations
- Rafsanjan University of Medical Sciences (IR)
- Rafsanjan University of Medical Sciences, Iran
- Venue
- Brazilian Oral Research
- Publisher
- FapUNIFESP (SciELO)
- Published
- 2010-03
- Volume
- 24
- Issue
- 1
- Pages
- 21-27
- ISSN
- 1517-7491 (ISSN-L)
- 1806-8324
- OpenAlex
- W2143032791
- Cited by
- 100
- References
- 18
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 7 · 2023: 13 · 2022: 9 · 2021: 10 · 2020: 9 · 2019: 2 · 2018: 8 · 2017: 4 · 2016: 6 · 2015: 10 · 2014: 5 · 2013: 6 · 2012: 2
- FWCI
- 1.95
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc
- Locations
- Brazilian Oral Research (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- Americanae (AECID Library) (submittedVersion, cc-by-nc)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Physiology › Salivary Gland Disorders and Functions
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › HIV/AIDS oral health manifestations
- Health Sciences › Medicine › Physiology › Clinical Laboratory Practices and Quality Control
- Keywords
- salivary IgA, age-related changes, sex differences, salivary immunoglobulins, healthy volunteers, immunosenescence
- MeSH terms
- Adolescent, Adult, Age Factors, Aged, Child, Child, Preschool, Enzyme-Linked Immunosorbent Assay, Epidemiologic Methods, Female, Humans, Immunoglobulin A, Immunoglobulins, Immunologic Factors, Infant, Male, Middle Aged, Saliva, Sex Factors, Young Adult
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