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Cited by 31Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsHistorical and Modern Theater Studies

Frontal presentation of Alzheimer's disease: A series of patients with biological evidence by CSF biomarkers

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Souza, Leonardo Cruz de, Bertoux, Maxime, Funkiewiez, Aurélie, Samri, Dalila, Azuar, Carole, Habert, Marie-Odile, Kas, Aurélie, Lamari, Foudil +2 more·2013·Dementia & Neuropsychologia
DOI 10.1590/s1980-57642013dn70100011PMC PMC5619547
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Abstract

ABSTRACT Besides its typical amnesic presentation, focal atypical presentations of Alzheimer's disease (AD) have been described in neuropathological studies. These phenotypical variants of AD (so-called "atypical AD") do not follow the typical amnestic pattern and include non-amnestic focal cortical syndromes, such as posterior cortical atrophy and frontal variant AD. These variants exhibit characteristic histological lesions of Alzheimer pathology at post-mortem exam. By using physiopathological markers, such as cerebrospinal fluid markers, it is now possible to establish in vivo a biological diagnosis of AD in these focal cortical syndromes. We report a series of eight patients who were diagnosed with behavioural variant frontotemporal dementia based on their clinical, neuropsychological and neuroimaging findings, while CSF biomarkers showed an AD biological profile, thus supporting a diagnosis of frontal variant of AD.

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  • A higher p-tau/Aβ42 ratio (>0.21) is observed in fvAD compared to bvFTD, with sensitivity and specificity of about 92%.

    “A higher p-tau/Aβ42 ratio (>0.21) is observed in fvAD compared to bvFTD (sensitivity and specificity of about 92%) [25].”

    From Diagnosing the frontal variant of Alzheimer’s disease: a clinician’s yellow brick road (2017) · cites this paper as [25]

    The Methods define the frontal AD group by a P-Tau/Aβ42 ratio above 0.21 and the bvFTD comparison group by a ratio below 0.21. They also report 91.2% sensitivity and 92.6% specificity for distinguishing AD from bvFTD, but do not establish those figures specifically for distinguishing frontal-variant AD from bvFTD. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

  • Early recall impairment in fvAD is due to the inability to consolidate memories.

    “Early recall impairment in fvAD is due to the inability to consolidate memories [25].”

    From Diagnosing the frontal variant of Alzheimer’s disease: a clinician’s yellow brick road (2017) · cites this paper as [25]

    The Results (page not specified) report impaired recall in five of eight patients with frontal-variant AD: low free recall was not normalized by cueing. The paper does not attribute this impairment to an inability to consolidate memories or establish that it occurred early in the disease. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

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Authors
Souza, L. C. D., Bertoux, M., Funkiewiez, A., Samri, D., Azuar, C., Habert, M.-O., Kas, A., Lamari, F., Sarazin, M., & Dubois, B.
Affiliations
  • Centre National de la Recherche Scientifique (FR)
  • Assistance Publique – Hôpitaux de Paris (FR)
  • Pitié-Salpêtrière Hospital (FR)
Corresponding author
Souza, Leonardo Cruz de
ORCID
Venue
Dementia & Neuropsychologia
Publisher
FapUNIFESP (SciELO)
Published
2013-03
Volume
7
Issue
1
Pages
66-74
ISSN
1980-5764 (ISSN-L)
DOI
10.1590/s1980-57642013dn70100011
PMC
PMC5619547
OpenAlex
W2135904680
Cited by
31
References
12
Citations by year
2026: 1 · 2025: 2 · 2024: 2 · 2023: 3 · 2022: 5 · 2021: 2 · 2020: 3 · 2019: 6 · 2017: 1 · 2016: 4 · 2015: 1 · 2014: 1
FWCI
1.42
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Dementia & Neuropsychologia (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
  • Americanae (AECID Library) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Redalyc (Universidad Autónoma del Estado de México) (submittedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
Keywords
Alzheimer's disease, behavioral variant frontotemporal dementia, cerebrospinal fluid biomarkers, posterior cortical atrophy

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