The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Preparation, characterization and evaluation of moisturizing and UV protecting effects of topical solid lipid nanoparticles
Open accessAbstract
Solid lipid nanoparticles (SLN) were recently proposed as carriers for various pharmaceutical and cosmetic actives. These lipid nanoparticles can act as moisturizers and physical sunscreens on their own. Therefore, the full potential of these carriers has yet to be determined. The present study was aimed to determine and compare moisturizing and UV-protecting effects of different solid lipid nanoparticles (SLN) prepared by different solid lipids including Glyceryl monostearate (GMS), Precirol® (P) and cetyl palmitate (CP) as carrier systems of moisturizers and sunscreens. The influence of the size and matrix crystallinity of the solid lipids on the occlusive factor, skin hydration and UV-protection were evaluated by in vitro and in vivo methods. The SLN were prepared by high-shear homogenization and ultrasound methods. Size, zeta potential and morphological characteristics of the samples were assessed by transmission electron microscopy (TEM) and thermotropic properties with differential scanning calorimetry (DSC) technique. Results of the assessments showed that SLN-CP significantly increases skin hydration and UV-protection, compared to SLN-GMS and SLN-P. It was demonstrated that the size of SLN, crystallinity index of solid lipid in SLN and probably other mechanisms besides the occlusive factor can influence skin hydration and UV-protection indices. Furthermore, findings of the assessments demonstrated significant difference between in vitro and in vivo assessments regarding occlusive factor and moisturizing effects. Findings of the present study indicate that the SLN-CP could be a promising carrier for sunscreens and moisturizers.
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“Particularly, soy isoflavones deposited in the dermal matrix were found to be more effective and exhibits greater penetration into the stratum cornea when they were in the form of solid lipid nanoparticles [81, 82].”
From AN OVERVIEW OF NEW TRENDS IN THE COSMETICS INDUSTRY (2025) · cites this paper as [81]
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“However, improved skin biocompatibility, enhanced photoaging, and enhanced anti-aging potential were demonstrated by biocompatible nano-lipoidal carriers of isotretinoin.”
From AN OVERVIEW OF NEW TRENDS IN THE COSMETICS INDUSTRY (2025) · cites this paper as [81]
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Metadata
- Authors
- Golmohammadzadeh, S., Mokhtari, M., & Jaafari, M. R.
- Affiliations
- Mashhad University of Medical Sciences (IR)
- Venue
- Brazilian Journal of Pharmaceutical Sciences
- Publisher
- FapUNIFESP (SciELO)
- Published
- 2012-12
- Volume
- 48
- Issue
- 4
- Pages
- 683-690
- ISSN
- 1984-8250 (ISSN-L)
- OpenAlex
- W2109755040
- Cited by
- 28
- References
- 31
- Citations by year
- 2025: 1 · 2023: 2 · 2022: 4 · 2021: 1 · 2020: 8 · 2019: 5 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 1 · 2013: 1
- FWCI
- 0.40
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc
- Locations
- Brazilian Journal of Pharmaceutical Sciences (publishedVersion, cc-by-nc)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- Americanae (AECID Library) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- solid lipid nanoparticles, emollients, physical sunscreens, UV protection, skin hydration, cetyl palmitate, glyceryl monostearate, Precirol, nanoparticle size, high shear homogenization, topical drug delivery
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