The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Preparation, characterization and evaluation of moisturizing and UV protecting effects of topical solid lipid nanoparticles
Open accessAbstract
Solid lipid nanoparticles (SLN) were recently proposed as carriers for various pharmaceutical and cosmetic actives. These lipid nanoparticles can act as moisturizers and physical sunscreens on their own. Therefore, the full potential of these carriers has yet to be determined. The present study was aimed to determine and compare moisturizing and UV-protecting effects of different solid lipid nanoparticles (SLN) prepared by different solid lipids including Glyceryl monostearate (GMS), Precirol® (P) and cetyl palmitate (CP) as carrier systems of moisturizers and sunscreens. The influence of the size and matrix crystallinity of the solid lipids on the occlusive factor, skin hydration and UV-protection were evaluated by in vitro and in vivo methods. The SLN were prepared by high-shear homogenization and ultrasound methods. Size, zeta potential and morphological characteristics of the samples were assessed by transmission electron microscopy (TEM) and thermotropic properties with differential scanning calorimetry (DSC) technique. Results of the assessments showed that SLN-CP significantly increases skin hydration and UV-protection, compared to SLN-GMS and SLN-P. It was demonstrated that the size of SLN, crystallinity index of solid lipid in SLN and probably other mechanisms besides the occlusive factor can influence skin hydration and UV-protection indices. Furthermore, findings of the assessments demonstrated significant difference between in vitro and in vivo assessments regarding occlusive factor and moisturizing effects. Findings of the present study indicate that the SLN-CP could be a promising carrier for sunscreens and moisturizers.
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“Particularly, soy isoflavones deposited in the dermal matrix were found to be more effective and exhibits greater penetration into the stratum cornea when they were in the form of solid lipid nanoparticles [81, 82].”
From AN OVERVIEW OF NEW TRENDS IN THE COSMETICS INDUSTRY (2025) · cites this paper as [81]
In the citing paper
“However, improved skin biocompatibility, enhanced photoaging, and enhanced anti-aging potential were demonstrated by biocompatible nano-lipoidal carriers of isotretinoin.”
From AN OVERVIEW OF NEW TRENDS IN THE COSMETICS INDUSTRY (2025) · cites this paper as [81]
Citations
Cites
Solid lipid nanoparticles (SLN) for controlled drug delivery – a review of the state of the art
Müller, R. (2000) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/s0939-6411(00)00087-4 · Cited by 3,836
Solid lipid nanoparticles (SLN) for controlled drug delivery – Drug release and release mechanism
Mühlen, A. Z., Schwarz, C., & Mehnert, W. (1998) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/s0939-6411(97)00150-1 · Cited by 945
Particle size of liposomes influences dermal delivery of substances into skin
Verma, D. K. (2003) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(03)00183-2 · Cited by 704
Souto, E. B., Wissing, S. A., Barbosa, C. M., & Müller, R. H. (2004) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2004.02.032 · Cited by 692
Preparation, characterization and in vitro release kinetics of clozapine solid lipid nanoparticles
Venkateswarlu, V., & Manjunath, K. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.01.005 · Cited by 565
The production and characteristics of solid lipid nanoparticles (SLNs)
Hou, D., Xie, C., Huang, K., & Zhu, C. (2003) · Biomaterials · doi:10.1016/s0142-9612(02)00578-1 · Cited by 439
Solid lipid nanoparticles as carrier for sunscreens: in vitro release and in vivo skin penetration
Wissing, S. A., & Müller, R. H. (2002) · Journal of Controlled Release · doi:10.1016/s0168-3659(02)00056-1 · Cited by 405
Isotretinoin-loaded solid lipid nanoparticles with skin targeting for topical delivery
Liu, J., Hu, W. S., Chen, H., Ni, Q., Xu, H., & Yang, X. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2006.08.007 · Cited by 384
Cosmetic applications for solid lipid nanoparticles (SLN)
Wissing, S. A. (2003) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(02)00684-1 · Cited by 366
Kullavanijaya, P., & Lim, H. W. (2005) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2004.07.063 · Cited by 356
Encapsulation of retinoids in solid lipid nanoparticles (SLN)
Jenning, S. H. G. V. (2001) · Journal of Microencapsulation · doi:10.1080/02652040010000361 · Cited by 315
Cosmetic features and applications of lipid nanoparticles (SLN®, NLC®)
Souto, E. B., & Müller, R. H. (2008) · International Journal of Cosmetic Science · doi:10.1111/j.1468-2494.2008.00433.x · Cited by 268
Sator, P.-G., Schmidt, J. B., & Hönigsmann, H. (2003) · Journal of the American Academy of Dermatology · doi:10.1067/mjd.2003.105 · Cited by 257
Elias, P. M. (2008) · Current Allergy and Asthma Reports · doi:10.1007/s11882-008-0048-0 · Cited by 245
The influence of solid lipid nanoparticles on skin hydration and viscoelasticity – in vivo study
Wissing, S. A., & Müller, R. H. (2003) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/s0939-6411(03)00040-7 · Cited by 245
Occlusion vs. skin barrier function
Zhai, H., & Maibach, H. I. (2002) · Skin Research and Technology · doi:10.1046/j.0909-752x.2001.10311.x · Cited by 219
Kumar, V. V., Durairaj, C., Sistla, R., Veerabrahma, K., Rao, Y. M., & Diwan, P. V. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2006.11.004 · Cited by 213
The influence of the crystallinity of lipid nanoparticles on their occlusive properties
Wissing, S. A., & Müller, R. H. (2002) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(02)00220-x · Cited by 200
Investigations on the occlusive properties of solid lipid nanoparticles (SLN).
Wissing, S. A., Lippacher, A., & Müller, R. (2001) · PubMed · Cited by 199
Solid lipid nanoparticles as drug carriers for topical glucocorticoids
Maia, C. S., Mehnert, W., & Schäfer‐Korting, M. (2000) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(99)00413-5 · Cited by 190
A novel sunscreen system based on tocopherol acetate incorporated into solid lipid nanoparticles
Wissing, S. A., & Müller, R. H. (2001) · International Journal of Cosmetic Science · doi:10.1046/j.1467-2494.2001.00087.x · Cited by 184
Saupe, A., Wissing, S. A., Lenk, A., Schmidt, C., & Müller, R. H. (2005) · PubMed · Cited by 144
Alanen, E., Nuutinen, J., Nicklén, K., Lahtinen, T., & Mönkkönen, J. (2004) · Skin Research and Technology · doi:10.1111/j.1600-0846.2004.00050.x · Cited by 135
Solid lipid nanoparticles (SLN)--a novel carrier for UV blockers.
Wissing, S. A., & Müller, R. H. (2001) · PubMed · Cited by 126
Nanostructured lipid carriers as novel carrier for sunscreen formulations
Xia, Q., Saupe, A., Müller, R. H., & Souto, E. B. (2007) · International Journal of Cosmetic Science · doi:10.1111/j.1468-2494.2007.00410.x · Cited by 112
Characterization of diazepam submicron emulsion interface: Role of oleic acid
Levy, M. Y., Schutze, W., Fuhrer, C., & Benita, S. (1994) · Journal of Microencapsulation · doi:10.3109/02652049409040440 · Cited by 88
Human exposure to solar ultraviolet radiation
Diffey, B. L. (2002) · Journal of Cosmetic Dermatology · doi:10.1046/j.1473-2165.2002.00060.x · Cited by 84
Potard, G., Laugel, C., Schaefer, H. E., & Marty, J.-P. (2000) · Skin Pharmacology and Physiology · doi:10.1159/000029941 · Cited by 75
Li, Z., Yu, L., Zheng, L., & Geng, F. (2009) · Journal of Thermal Analysis and Calorimetry · doi:10.1007/s10973-009-0127-z · Cited by 34
Sunblocking efficiency of various TiO2‐loaded solid lipid nanoparticle formulations1
Cengiz, E., Wissing, S. A., Müller, R. H., & Yazan, Y. (2006) · International Journal of Cosmetic Science · doi:10.1111/j.1467-2494.2006.00320.x · Cited by 30
Shiva, G. M., Boroujeni, N. K., Jafari, M. R., & Greenoak, G. E. (2007) · Iranian journal of basic medical sciences. · doi:10.22038/ijbms.2007.5276 · Cited by 5
Research works printed but not linked: 1
- MULLER R.H., 2000, The next generation after the liposomes: solid lipid nanoparticles (SLNe, Lipopearlse) as dermal carrier in cosmetics, Eurocosmetics, 7, 19
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Severino, P. B., Silveira, E. F., Loureiro, K. C., Chaud, M. V., Antonini, D., Lancellotti, M., Sarmento, V. H. V., da Silva, C. F., Santana, M. H. A., & Souto, E. B. (2017) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2017.05.063 · Cited by 88
Khameneh, B., Halimi, V., Jaafari, M. R., & Golmohammadzadeh, S. (2015) · Europe PMC (PubMed Central) · Cited by 58
Self-citationRodrigues, L. R., & Jose, J. (2020) · Environmental Science and Pollution Research · doi:10.1007/s11356-020-08543-4 · Cited by 63
Nanotechnology application on bamboo materials: A review
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Metadata
- Authors
- Golmohammadzadeh, S., Mokhtari, M., & Jaafari, M. R.
- Affiliations
- Mashhad University of Medical Sciences (IR)
- Venue
- Brazilian Journal of Pharmaceutical Sciences
- Publisher
- FapUNIFESP (SciELO)
- Published
- 2012-12
- Volume
- 48
- Issue
- 4
- Pages
- 683-690
- ISSN
- 1984-8250 (ISSN-L)
- OpenAlex
- W2109755040
- Cited by
- 28
- References
- 31
- Citations by year
- 2025: 1 · 2023: 2 · 2022: 4 · 2021: 1 · 2020: 8 · 2019: 5 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 1 · 2013: 1
- FWCI
- 0.40
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc
- Locations
- Brazilian Journal of Pharmaceutical Sciences (publishedVersion, cc-by-nc)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- Americanae (AECID Library) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- solid lipid nanoparticles, emollients, physical sunscreens, UV protection, skin hydration, cetyl palmitate, glyceryl monostearate, Precirol, nanoparticle size, high shear homogenization, topical drug delivery
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