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Cited by 101Medication Adherence and ComplianceAttention Deficit Hyperactivity DisorderPharmaceutical studies and practices

The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.

Assessment of Adherence Measures with Different Stimulants Among Children and Adolescents

Sanchez, Robert J., Crismon, M. Lynn, Barner, Jamie C., Bettinger, Tawny, Wilson, James P.·2005·Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
DOI 10.1592/phco.2005.25.7.909
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Abstract

Study Objective. To examine adherence measures with different stimulants in children and adolescents. Design. Retrospective analysis. Data Source. Texas Medicaid prescription claims database. Patients. A total of 9549 patients aged 5–18 years with attention‐deficit—hyperactivity disorder. Measurements and Main Results. Paid prescription claims for newly started stimulants during the 2001–2002 school year were extracted from a database; 28,344 prescriptions (9549 patients) were available for analysis. Adherence was evaluated based on the drug therapy prescribed (i.e., mixed amphetamine salts, immediate‐release methylphenidate, and extended‐release methylphenidate—OROS [oral‐osmotic formulation]) and the age and sex of the patient. Adherence measures were persistence and medication possession ratio (MPR). Persistence was higher for extended‐release methylphenidate—OROS (0.50 ± 0.33) than for mixed amphetamine salts (0.42 ± 0.29) or immediate‐release methylphenidate (0.37 ± 0.26; p<0.001). The MPR was also higher for extended‐release methylphenidate—OROS (0.76 ± 0.37) than for mixed amphetamine salts (0.73 ± 0.37) or immediate‐release methylphenidate (0.69 ± 0.37; p<0.001). Patients aged 5–9 years had equal or better persistence and MPR than those aged 10–14 and 15–18 years (p<0.001). No sex‐related differences in adherence were observed. Conclusion. Adherence measures in our study were low. Although they were significantly better for extended‐release methylphenidate—OROS than the other stimulants, the clinical significance of these differences are unclear. Further research should be conducted regarding pharmaceutical products, administration methods, and clinical interventions that may enhance adherence.

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Research works printed but not linked: 4

  1. American Psychiatric Association., 1994, Diagnostic and statistical manual for mental disorders
  2. Tebbi CK., 1993, Treatment compliance in childhood and adolescence, Cancer, 71, 441
  3. Fine S, 2001, Issues in medication adherence for children and adolescents with attention deficit hyperactivity disorder, B C Med J, 43, 277
  4. American Psychiatric Association., 1987, Diagnostic and statistical manual for mental disorders

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Metadata

Authors
Sanchez, R. J., Crismon, M. L., Barner, J. C., Bettinger, T., & Wilson, J. P.
Affiliations
  • Texas Department of State Health Services (US)
  • Pfizer (United States) (US)
  • The University of Texas at Austin (US)
Corresponding author
Crismon, M. Lynn
ORCID
Venue
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
Publisher
Wiley
Published
2005-07
Volume
25
Issue
7
Pages
909-917
ISSN
  • 0277-0008 (ISSN-L)
  • 1875-9114
DOI
10.1592/phco.2005.25.7.909
OpenAlex
W2097767249
Cited by
101
References
50
Citations by year
2026: 2 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 4 · 2017: 4 · 2016: 4 · 2015: 6 · 2014: 9 · 2013: 4 · 2012: 10
FWCI
4.49
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 2390 d)
Locations
  • Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy (publishedVersion)
  • PubMed (publishedVersion)
Funders
Texas Department of State Health Services
Topics
  • Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
Keywords
medication adherence, attention deficit hyperactivity disorder, stimulant medication, extended-release methylphenidate, mixed amphetamine salts, immediate-release methylphenidate, medication possession ratio, persistence, children and adolescents
MeSH terms
Adolescent, Amphetamines, Central Nervous System Stimulants, Attention Deficit Disorder with Hyperactivity, Child, Child, Preschool, Delayed-Action Preparations, Female, Humans, Male, Methylphenidate, Patient Compliance, Retrospective Studies

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