Pancreatic enzyme pharmacotherapy
Abstract
Supplemental pancreatic enzyme preparations are provided to patients with conditions of pancreatic exocrine deficiency such as chronic pancreatitis and cystic fibrosis. These patients frequently experience steatorrhea, which occurs from inadequate fat absorption. The delivery of sufficient enzyme concentrations into the duodenal lumen simultaneously with meals can reduce nutrient malabsorption, improve the symptoms of steatorrhea, and in some cases alleviate the pain associated with chronic pancreatitis. Current clinical practices dictate administration of lipase 25,000-40,000 units/meal by using pH-sensitive pancrelipase microspheres, along with dosage increases, compliance checks, and differential diagnosis in cases of treatment failure. Despite the large number of specialty enzyme replacements available commercially, many patients remain dissatisfied with standard therapy, and future developments are needed to optimize treatment in these individuals.
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EPI occurs when 90% of the pancreatic enzyme output is diminished.
“EPI occurs when 90% of the pancreatic enzyme output is diminished, 54 and pancreatic enzyme replacement therapies may be necessary in such cases.”
From Familial chylomicronemia syndrome: Bringing to life dietary recommendations throughout the life span (2018) · cites this paper as [54]
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- Authors
- Ferrone, M., Raimondo, M., & Scolapio, J. S.
- Affiliations
- University of California, San Francisco (US)
- Mayo Clinic in Florida (US)
- Corresponding author
- Ferrone, Marcus
- Venue
- Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy
- Publisher
- Wiley
- Published
- 2007-06
- Volume
- 27
- Issue
- 6
- Pages
- 910-920
- ISSN
- 0277-0008 (ISSN-L)
- 1875-9114
- OpenAlex
- W1977626300
- Cited by
- 88
- References
- 64
- Citations by year
- 2025: 1 · 2024: 4 · 2023: 2 · 2021: 5 · 2020: 3 · 2019: 3 · 2018: 6 · 2017: 10 · 2016: 5 · 2015: 7 · 2014: 3 · 2013: 5 · 2012: 8
- FWCI
- 1.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Keywords
- pancreatic enzyme replacement therapy, pancrelipase, exocrine pancreatic insufficiency, chronic pancreatitis, cystic fibrosis, steatorrhea, fat malabsorption, treatment failure, medication adherence
- MeSH terms
- Cystic Fibrosis, Digestion, Gastrointestinal Agents, Humans, Pain, Pancreas, Exocrine Pancreatic Insufficiency, Pancreatin, Pancreatitis, Pancrelipase
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