Cited by 251Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and CancerCancer, Lipids, and Metabolism

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Hypoxia-Inducible Factor-1α and the Glycolytic Phenotype in Tumors

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Robey, Ian F., Lien, Anthony D., Welsh, Sarah J., Baggett, Brenda K., Gillies, Robert J.·2005·Neoplasia

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Abstract

Metastatic tumors generally exhibit aerobic glycolysis (the Warburg effect). The advent of [18F]fluorodeoxyglucose positron emission tomography imaging, coupled with recent findings linking hypoxia-inducible factor (HIF-1alpha) overexpression to aggressive cancers, has rekindled an interest in this aspect of tumor metabolism. These studies explore the role of HIF-1alpha in human breast cancer lines and its relationship to glycolytic regulation. Here we demonstrate that, under normal oxygen conditions, nonmetastatic cells consume less glucose and express low HIF-1alpha, whereas metastatic cells constitutively express high glycolysis and HIF-1alpha, suggesting that dysregulation of HIF-1alpha may induce the Warburg effect. This hypothesis was tested by renormalizing HIF-1alpha levels in renal carcinoma cells, leading to inhibition of aerobic glycolysis.

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Authors: Robey, I. F., Lien, A. D., Welsh, S. J., Baggett, B. K., & Gillies, R. J.
Affiliations: University of Arizona Cancer Center (US)
Corresponding author: Gillies, Robert J.
ORCID: Robey, Ian F.
Lien, Anthony D.
Welsh, Sarah J.
Baggett, Brenda K.
Gillies, Robert J.
Venue: Neoplasia
Publisher: Elsevier BV
Published: 2005-04
Volume: 7
Issue: 4
Pages: 324-330
ISSN: 1476-5586 (ISSN-L)
DOI: 10.1593/neo.04430
PMC: PMC1501147
OpenAlex: W2088715496
Cited by: 251
References: 45
Citations by year: 2026: 6 · 2025: 8 · 2024: 9 · 2023: 16 · 2022: 14 · 2021: 15 · 2020: 10 · 2019: 16 · 2018: 7 · 2017: 8 · 2016: 6 · 2015: 10 · 2014: 15 · 2013: 14 · 2012: 9
FWCI: 5.45
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by-nc-nd/3.0/ (vor, 3321 d)
Locations: Neoplasia (publishedVersion, cc-by-nc-nd)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders: National Institutes of Health
National Cancer Institute (R01-CA77575, R01CA077575, R01-CA77975-05)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
Keywords: hypoxia-inducible factor-1α, aerobic glycolysis, Warburg effect, cancer metabolism, metastasis, breast cancer cell lines, renal carcinoma cells, glucose utilization, glycolytic regulation, HIF-1α overexpression
MeSH terms: Hypoxia, Glucose, Glycolysis, Humans, Lactates, Neoplasms, Phenotype, Time Factors, Transcription Factors, Blotting, Western, Gene Expression Regulation, Neoplastic, DNA Primers, Reverse Transcriptase Polymerase Chain Reaction, Cell Line, Tumor, Hypoxia-Inducible Factor 1, alpha Subunit

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Hypoxia-Inducible Factor-1α and the Glycolytic Phenotype in Tumors

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