A Specific Inhibitor of TGF-β Receptor Kinase, SB-431542, as a Potent Antitumor Agent for Human Cancers
Open accessAbstract
Small molecule inhibitors of signaling pathways have proven to be extremely useful for the development of therapeutic strategies for human cancers. Blocking the tumor-promoting effects of transforming growth factor-beta (TGF-beta) in advanced stage carcinogenesis provides a potentially interesting drug target for therapeutic intervention. Although very few TGF-beta receptor kinase inhibitors (TRKI) are now emerging in preclinical studies, nothing is known about how these inhibitors might regulate the tumor-suppressive or tumor-promoting effects of TGF-beta, or when these inhibitors might be useful for treatment during cancer progression. We have investigated the potential of TRKI in new therapeutic approaches in preclinical models. Here, we demonstrate that the TRKI, SB-431542, inhibits TGF-beta-induced transcription, gene expression, apoptosis, and growth suppression. We have observed that SB-431542 attenuates the tumor-promoting effects of TGF-beta, including TGF-beta-induced EMT, cell motility, migration and invasion, and vascular endothelial growth factor secretion in human cancer cell lines. Interestingly, SB-431542 induces anchorage independent growth of cells that are growth-inhibited by TGF-beta, whereas it reduces colony formation by cells that are growth-promoted by TGF-beta. However, SB-431542 has no effect on a cell line that failed to respond to TGF-beta. This represents a novel potential application of these inhibitors as therapeutic agents for human cancers with the goal of blocking tumor invasion, angiogenesis, and metastasis, when tumors are refractory to TGF-beta-induced tumor-suppressor functions but responsive to tumor-promoting effects of TGF-beta.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
JSH-23 suppresses NF-κB signaling and SB-431542 suppresses TGF-β1/Smad3 signaling.
“JSH-23 and SB-431542 can suppress NF-κB and TGF-β1/Smad3 signaling pathways respectively and thus might inhibit platelet aggregation in endometriosis91,92.”
From Platelets induce increased estrogen production through NF-κB and TGF-β1 signaling pathways in endometriotic stromal cells (2020) · cites this paper as [92]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Massagué, J. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.753 · Cited by 7,571 · see citing works
Lessons from hereditary colorectal cancer
Kinzler, K. W., & Vogelstein, B. (1996) · Cell · doi:10.1016/s0092-8674(00)81333-1 · Cited by 4,919 · see citing works
TGF-β signalling from cell membrane to nucleus through SMAD proteins
Heldin, C., Miyazono, K., & ten Dijke, P. (1997) · Nature · doi:10.1038/37284 · Cited by 3,697 · see citing works
TGF-β Signaling in Tumor Suppression and Cancer Progression
Derynck, R., Akhurst, R. J., & Balmain, A. (2001) · Nature Genetics · doi:10.1038/ng1001-117 · Cited by 2,275 · see citing works
Transcriptional control by the TGF‐β/Smad signaling system
Massagué, J., & Wotton, D. (2000) · The EMBO Journal · doi:10.1093/emboj/19.8.1745 · Cited by 1,969 · see citing works
Inman, G. J., Nicolás, F. J., Callahan, J. F., Harling, J. D., Gaster, L. M., Reith, A. D., Laping, N. J., & Hill, C. S. (2002) · Molecular Pharmacology · doi:10.1124/mol.62.1.65 · Cited by 1,636 · see citing works
Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer
Siegel, P. M., & Massagué, J. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1208 · Cited by 1,600 · see citing works
Bhowmick, N., Ghiassi, M., Bakin, A. V., Aakre, M., Lundquist, C., Engel, M., Arteaga, C., & Moses, H. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.1.27 · Cited by 1,087 · see citing works
Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response
Ashcroft, G. S., Yang, X., Glick, A. B., Weinstein, M., Letterio, J. J., Mizel, D. E., Anzano, M., Greenwell-Wild, T., Wahl, S. M., Deng, C., et al. (1999) · Nature Cell Biology · doi:10.1038/12971 · Cited by 911 · see citing works
TGF-β signaling: positive and negative effects on tumorigenesis
Wakefield, L. M. (2002) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(01)00259-3 · Cited by 827 · see citing works
Stimulation of the chemotactic migration of human fibroblasts by transforming growth factor beta.
Postlethwaite, A. E., Keski-Oja, J., Moses, H. L., & Kang, A. H. (1987) · The Journal of experimental medicine · doi:10.1084/jem.165.1.251 · Cited by 777 · see citing works
Laping, N. J., Grygielko, E. T., Mathur, A., Butter, S., Bomberger, J. M., Tweed, C. W., Martin, W., Fornwald, J. A., Lehr, R. V., Harling, J. D., et al. (2002) · Molecular Pharmacology · doi:10.1124/mol.62.1.58 · Cited by 638 · see citing works
TGFβ signaling is necessary for carcinoma cell invasiveness and metastasis
Oft, M., Heider, K., & Beug, H. (1998) · Current Biology · doi:10.1016/s0960-9822(07)00533-7 · Cited by 624 · see citing works
Smads as transcriptional co-modulators
Attisano, L., & Wrana, J. L. (2000) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(99)00081-2 · Cited by 523 · see citing works
Role of Transforming Growth Factor-beta Signaling in Cancer
de Caestecker, M. P. (2000) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/92.17.1388 · Cited by 521 · see citing works
Blockade of TGF-β inhibits mammary tumor cell viability, migration, and metastases
Muraoka, R. S., Dumont, N., Ritter, C. A., Dugger, T. C., Brantley, D. M., Chen, J., Easterly, E., Roebuck, L. R., Ryan, S. T., Gotwals, P. J., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15234 · Cited by 485 · see citing works
Bakin, A. V., Rinehart, C., Tomlinson, A. K., & Arteaga, C. L. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.15.3193 · Cited by 430 · see citing works
Blockade of TGF-β inhibits mammary tumor cell viability, migration, and metastases
Muraoka, R. S., Dumont, N., Ritter, C. A., Dugger, T. C., Brantley, D. M., Chen, J., Easterly, E., Roebuck, L. R., Ryan, S. T., Gotwals, P. J., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215234 · Cited by 415 · see citing works
Yang, Y.-A., Dukhanina, O. I., Tang, B., Mamura, M., Letterio, J. J., MacGregor, J., Patel, S. C., Khozin, S., Liu, Z.-Y., Green, J. D., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15333 · Cited by 404 · see citing works
Yang, Y.-A., Dukhanina, O., Tang, B., Mamura, M., Letterio, J. J., MacGregor, J., Patel, S. C., Khozin, S., Liu, Z.-Y., Green, J., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci200215333 · Cited by 404 · see citing works
Ellenrieder, V., Hendler, S. F., Boeck, W., Seufferlein, T., Menke, A., Ruhland, C., Adler, G., & Gress, T. M. (2001) · PubMed · Cited by 361 · see citing works
Callahan, J. F., Burgess, J. L., Fornwald, J. A., Gaster, L. M., Harling, J. D., Harrington, F. P., Heer, J. P., Kwon, C., Lehr, R. V., Mathur, A., et al. (2002) · Journal of Medicinal Chemistry · doi:10.1021/jm010493y · Cited by 309 · see citing works
Targeting the TGFβ signaling network in human neoplasia
Dumont, N., & Arteaga, C. L. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00135-1 · Cited by 243 · see citing works
Sheng, H., Shao, J., Dixon, D. A., Williams, C. S., Prescott, S. M., DuBois, R. N., & Beauchamp, R. D. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.9.6628 · Cited by 196 · see citing works
Self-citationHjelmeland, M. D., Hjelmeland, A. B., Sathornsumetee, S., Reese, E. D., Herbstreith, M. H., Laping, N. J., Friedman, H. S., Bigner, D. D., Wang, X.-F., & Rich, J. N. (2004) · PubMed · Cited by 192 · see citing works
Hjelmeland, M. D., Hjelmeland, A. B., Sathornsumetee, S., Reese, E. D., Herbstreith, M. H., Laping, N. J., Friedman, H. S., Bigner, D. D., Wang, X., & Rich, J. N. (2004) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.737.3.6 · Cited by 177 · see citing works
Watabe, T., Nishihara, A., Mishima, K., Yamashita, J. K., Shimizu, K., Miyazawa, K., Nishikawa, S., & Miyazono, K. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200305147 · Cited by 176 · see citing works
Matsuyama, S., Iwadate, M., Kondo, M., Saitoh, M., Hanyu, A., Shimizu, K., Aburatani, H., Mishima, H. K., Imamura, T., Miyazono, K., et al. (2003) · PubMed · Cited by 142 · see citing works
Chemoinformatics – predicting the physicochemical properties of 'drug-like' molecules
Blake, J. F. (2000) · Current Opinion in Biotechnology · doi:10.1016/s0958-1669(99)00062-2 · Cited by 137 · see citing works
Growth factors and transformation.
Roberts, A. B., & Sporn, M. B. (1986) · PubMed · Cited by 128 · see citing works
Diet diversity and gastric cancer
Vecchia, C. L., Muñoz, S. E., Braga, C., Fernández, E., & Decarli, A. (1997) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19970717)72:2 · Cited by 107 · see citing works
Osada, H., Tatematsu, Y., Masuda, A., Saito, T., Sugiyama, M., Yanagisawa, K., & Takahashi, T. (2001) · PubMed · Cited by 83 · see citing works
Signal Transduction of the TGF- Superfamily by Smad Proteins
Kawabata, M., & Miyazono, K. (1999) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a022273 · Cited by 65 · see citing works
Wrana, J. L. (2000) · Science s STKE · doi:10.1126/stke.2000.23.re1 · Cited by 52 · see citing works
Flagged first, then by citations
3 of the 37 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
TGF-β signaling in health, disease and therapeutics
Deng, Z., Fan, T. T., Chu, X., Tian, H., Zheng, Y., Li, C., & He, J. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01764-w · Cited by 1,270 · see citing works
Tissue invasion and metastasis: Molecular, biological and clinical perspectives
Jiang, W. G., Sanders, A. J., Katoh, M., Ungefroren, H., Gieseler, F., Prince, M. E., Thompson, S. K., Zollo, M., Spano, D., Dhawan, P., et al. (2015) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2015.03.008 · Cited by 514 · see citing works
Spencer, M., Yao-Borengasser, A., Unal, R., Rasouli, N., Gurley, C. M., Zhu, B., Peterson, C. A., & Kern, P. A. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00329.2010 · Cited by 439 · see citing works
Dysregulation of growth factor signaling in human hepatocellular carcinoma
Breuhahn, K., Longerich, T., & Schirmacher, P. (2006) · Oncogene · doi:10.1038/sj.onc.1209556 · Cited by 392 · see citing works
Epithelial–mesenchymal transition and tumour invasion
Guarino, M. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2007.07.011 · Cited by 369 · see citing works
Targeting EMT in cancer: opportunities for pharmacological intervention
Davis, F. M., Stewart, T. A., Thompson, E. W., & Monteith, G. R. (2014) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2014.06.006 · Cited by 361 · see citing works
EMT Factors and Metabolic Pathways in Cancer
Georgakopoulos‐Soares, I., Chartoumpekis, D. V., Kyriazopoulou, V. E., & Zaravinos, A. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00499 · Cited by 348 · see citing works
Melisi, D., Ishiyama, S., Sclabas, G. M., Fleming, J. B., Xia, Q., Tortora, G., Abbruzzese, J. L., & Chiao, P. J. (2008) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-07-0337 · Cited by 324 · see citing works
Drug resistance in cancer: mechanisms and tackling strategies
Haider, T., Pandey, V., Banjare, N., Gupta, P. N., & Soni, V. (2020) · Pharmacological Reports · doi:10.1007/s43440-020-00138-7 · Cited by 312 · see citing works
Rout-Pitt, N., Farrow, N., Parsons, D., & Donnelley, M. (2018) · Respiratory Research · doi:10.1186/s12931-018-0834-8 · Cited by 275 · see citing works
Haynes, J., Srivastava, J., Madson, N., Wittmann, T., & Barber, D. L. (2011) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-02-0119 · Cited by 241 · see citing works
Quan, T., Shao, Y., He, T., Voorhees, J. J., & Fisher, G. J. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2009.224 · Cited by 239 · see citing works
Antimetastatic Role of Smad4 Signaling in Colorectal Cancer
Zhang, B., Halder, S. K., Kashikar, N., Cho, Y., Datta, A., Gorden, D. L., & Datta, P. K. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.11.004 · Cited by 221 · see citing works
Self-citationJordan, N. V., Johnson, G. L., & Abell, A. N. (2011) · Cell Cycle · doi:10.4161/cc.10.17.17188 · Cited by 220 · see citing works
Patsialou, A., Wyckoff, J. B., Wang, Y., Goswami, S., Stanley, E. R., & Condeelis, J. S. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-1868 · Cited by 207 · see citing works
Transforming Growth Factor-β in the Gastrointestinal and Hepatic Tumor Microenvironment
Achyut, B. R., & Yang, H. H. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.07.048 · Cited by 200 · see citing works
Activin signaling as an emerging target for therapeutic interventions
Tsuchida, K., Nakatani, M., Hitachi, K., Uezumi, A., Sunada, Y., Ageta, H., & Inokuchi, K. (2009) · Cell Communication and Signaling · doi:10.1186/1478-811x-7-15 · Cited by 195 · see citing works
Molecular and cellular mechanisms of chemoresistance in pancreatic cancer
Adamska, A., Elaskalani, O., Emmanouilidi, A., Kim, M. K., Razak, N. B. A., Metharom, P., & Falasca, M. (2017) · Advances in Biological Regulation · doi:10.1016/j.jbior.2017.11.007 · Cited by 184 · see citing works
Canonical TGF-β Signaling Pathway Represses Human NK Cell Metabolism
Zaiatz-Bittencourt, V., Finlay, D. K., & Gardiner, C. M. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1701461 · Cited by 177 · see citing works
Lou, C. H., Shao, A., Shum, E. Y., Espinoza, J. L., Huang, L., Karam, R., & Wilkinson, M. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.01.028 · Cited by 172 · see citing works
Tsuchida, K., Nakatani, M., Uezumi, A., Murakami, T., & Cui, X. (2008) · Endocrine Journal · doi:10.1507/endocrj.kr-110 · Cited by 163 · see citing works
Transforming growth factor‐β in cutaneous melanoma
Javelaud, D., Alexaki, V. I., & Mauviel, A. (2008) · Pigment Cell & Melanoma Research · doi:10.1111/j.1755-148x.2008.00450.x · Cited by 150 · see citing works
Koopman Van Aarsen, L. A., Leone, D. R., Ho, S., Dolinski, B. M., McCoon, P. E., LePage, D. J., Kelly, R., Heaney, G., Rayhorn, P., Reid, C., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-2307 · Cited by 146 · see citing works
Exploring anti-TGF-β therapies in cancer and fibrosis
Hawinkels, L. J. A. C., & ten Dijke, P. (2011) · Growth Factors · doi:10.3109/08977194.2011.595411 · Cited by 145 · see citing works
TGF-β signaling in liver and gastrointestinal cancers
Katz, L. H., Likhter, M., Jogunoori, W. S., Belkin, M. D., Ohshiro, K., & Mishra, L. (2016) · Cancer Letters · doi:10.1016/j.canlet.2016.03.033 · Cited by 145 · see citing works
Patsialou, A., Wang, Y., Lin, J., Whitney, K. D., Goswami, S., Kenny, P. A., & Condeelis, J. S. (2012) · Breast Cancer Research · doi:10.1186/bcr3344 · Cited by 144 · see citing works
Izdebska, M., Zielińska, W., Grzanka, D., & Gagat, M. (2018) · BioMed Research International · doi:10.1155/2018/4578373 · Cited by 142 · see citing works
Tumor-Derived Extracellular Vesicles Inhibit Natural Killer Cell Function in Pancreatic Cancer
Zhao, J., Schlößer, H., Wang, Z., Qin, J., Li, J., Popp, F., Popp, M. C., Alakus, H., Chon, S., Hansen, H. P., et al. (2019) · Cancers · doi:10.3390/cancers11060874 · Cited by 142 · see citing works
Targeting transforming growth factor-β signaling in liver metastasis of colon cancer
Zhang, B., Halder, S. K., Zhang, S., & Datta, P. K. (2009) · Cancer Letters · doi:10.1016/j.canlet.2008.11.035 · Cited by 134 · see citing works
Self-citationQuan, T., He, T., Shao, Y., Lin, L., Kang, S., Voorhees, J. J., & Fisher, G. J. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.060128 · Cited by 130 · see citing works
Immunity and Immune Suppression in Human Ovarian Cancer
Preston, C. C., Goode, E. L., Hartmann, L. C., Kalli, K. R., & Knutson, K. L. (2011) · Immunotherapy · doi:10.2217/imt.11.20 · Cited by 130 · see citing works
Gaspar, N. J., Li, L., Kapoun, A. M., Medicherla, S., Reddy, M., Li, G., O’Young, G., Quon, D. H., Henson, M., Damm, D. L., et al. (2007) · Molecular Pharmacology · doi:10.1124/mol.106.029025 · Cited by 120 · see citing works
Dovizio, M., Maier, T. J., Alberti, S., Francesco, L. D., Marcantoni, E., Münch, G., John, C. M., Suess, B., Sgambato, A., Steinhilber, D., et al. (2013) · Molecular Pharmacology · doi:10.1124/mol.113.084988 · Cited by 120 · see citing works
CCT6A suppresses SMAD2 and promotes prometastatic TGF-β signaling
Ying, Z., Tian, H., Li, Y., Lian, R., Li, W., Wu, S., Zhang, H., Wu, J., Liu, L., Song, J., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci90439 · Cited by 120 · see citing works
Transforming growth factor-beta signaling and tumor angiogenesis
Pardali, E. (2009) · Frontiers in bioscience · doi:10.2741/3573 · Cited by 117 · see citing works
Mancarella, S., Cigliano, A., Chieti, A., Giannelli, G., & Dituri, F. (2018) · Seminars in Liver Disease · doi:10.1055/s-0038-1676121 · Cited by 114 · see citing works
Zhang, B., Zhang, B., Chen, X., Bae, S., Singh, K. P., Washington, M. K., & Datta, P. K. (2014) · British Journal of Cancer · doi:10.1038/bjc.2013.789 · Cited by 113 · see citing works
Self-citationDrabsch, Y., He, S., Zhang, L., Snaar-Jagalska, E. B., & ten Dijke, P. (2013) · Breast Cancer Research · doi:10.1186/bcr3573 · Cited by 113 · see citing works
Micalizzi, D. S., Wang, C.-A., Farabaugh, S. M., Schiemann, W. P., & Ford, H. L. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-1354 · Cited by 113 · see citing works
Lou, C., Zhang, F., Yang, M., Zhao, J., Zeng, W., Fang, X., Zhang, Y., Zhang, C., & Liang, W. P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050956 · Cited by 109 · see citing works
Das, S., Becker, B. N., Hoffmann, F. M., & Mertz, J. E. (2009) · BMC Cell Biology · doi:10.1186/1471-2121-10-94 · Cited by 109 · see citing works
NF-κB signaling in neoplastic transition from epithelial to mesenchymal phenotype
Oh, A., Pardo, M. R., Rodriguez, A., Yu, C., Nguyen, L., Liang, O. D., Chorzalska, A. D., & Dubielecka, P. M. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01207-z · Cited by 110 · see citing works
Drug development against metastasis-related genes and their pathways: A rationale for cancer therapy
Iiizumi, M., Liu, W., Pai, S. K., Furuta, E., & Watabe, K. (2008) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2008.07.002 · Cited by 105 · see citing works
Inhibition of TGFβ signaling in cancer therapy
Arteaga, C. L. (2005) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2005.12.009 · Cited by 105 · see citing works
Delayed stress fiber formation mediates pulmonary myofibroblast differentiation in response to TGF-β
Sandbo, N. K., Lau, A., Kach, J., Ngam, C. R., Yau, D. M., & Dulin, N. O. (2011) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00166.2011 · Cited by 104 · see citing works
Wildi, S., Kleeff, J. H., Mayerle, J. V., Zimmermann, A., Böttinger, E. P., Wakefield, L. M., Büchler, M. W., Frieß, H., & Korc, M. (2006) · Gut · doi:10.1136/gut.2006.105833 · Cited by 102 · see citing works
Bedel, R., Thiery-Vuillemin, A., Grandclément, C., Balland, J., Rémy-Martin, J.-P., Kantelip, B. M., Pallandre, J., Pivot, X. B., Ferrand, C., Tiberghien, P., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-09-4540 · Cited by 99 · see citing works
EMT and Stemness—Key Players in Pancreatic Cancer Stem Cells
Rodríguez-Aznar, E., Wiesmüller, L., Sainz, B., & Hermann, P. (2019) · Cancers · doi:10.3390/cancers11081136 · Cited by 93 · see citing works
Triple-Negative Breast Cancer Cells Recruit Neutrophils by Secreting TGF-β and CXCR2 Ligands
SenGupta, S., Hein, L. E., Xu, Y., Zhang, J., Konwerski, J. R., Li, Y., Johnson, C. N., Cai, D., Smith, J. L., & Parent, C. A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.659996 · Cited by 93 · see citing works
Cipriano, R., Kan, C. E., Graham, J., Danielpour, D., Stampfer, M., & Jackson, M. W. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1015022108 · Cited by 92 · see citing works
Oncogenic Function of a Novel WD-Domain Protein, STRAP, in Human Carcinogenesis
Halder, S. K., Anumanthan, G., Maddula, R., Mann, J. R., Chytil, A. M., Gonzalez, A. L., Washington, M. K., Moses, H. L., Beauchamp, R. D., & Datta, P. K. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3261 · Cited by 91 · see citing works
Self-citationTGF-β signaling networks in the tumor microenvironment
Chan, M. K.-K., Chung, J. Y.-F., Tang, P. C.-T., Chan, A. S.-W., Ho, J. Y.-Y., Lin, T. P.-T., Chen, J., Leung, K.-T., To, K.-F., Lan, H.-Y., et al. (2022) · Cancer Letters · doi:10.1016/j.canlet.2022.215925 · Cited by 90 · see citing works
Zhang, W., Liu, Y., Sun, N., Wang, D., Boyd-Kirkup, J. D., Dou, X., & Han, J. J. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.07.010 · Cited by 89 · see citing works
Liu, Z., Kobayashi, K., van Dinther, M., van Heiningen, S. H., Valdimarsdóttir, G., van Laar, T., Scharpfenecker, M., Löwik, C. W. G. M., Goumans, M., ten Dijke, P., et al. (2009) · Journal of Cell Science · doi:10.1242/jcs.048942 · Cited by 89 · see citing works
Cell surface thermal proteome profiling tracks perturbations and drug targets on the plasma membrane
Kalxdorf, M., Günthner, I., Becher, I., Kurzawa, N., Knecht, S., Savitski, M. M., Eberl, H. C., & Bantscheff, M. (2021) · Nature Methods · doi:10.1038/s41592-020-01022-1 · Cited by 88 · see citing works
Nagathihalli, N. S., Massion, P. P., Gonzalez, A. L., Wang, L., & Datta, P. K. (2012) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-12-0107 · Cited by 86 · see citing works
Self-citationDemagny, H., Araki, T., & Robertis, E. M. D. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.09.020 · Cited by 85 · see citing works
Liaghat, M., Ferdousmakan, S., Mortazavi, S. H., Yahyazadeh, S., Irani, A., Banihashemi, S., Asl, F. S. S., Akbari, A., Farzam, F., Aziziyan, F., et al. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01957-4 · Cited by 84 · see citing works
Role of Transforming Growth Factor-β In Cancer Progression
Galliher, A. J., Neil, J. R., & Schiemann, W. P. (2006) · Future Oncology · doi:10.2217/14796694.2.6.743 · Cited by 80 · see citing works
Epithelial-to-Mesenchymal Transition and MicroRNAs in Lung Cancer
Legras, A., Pécuchet, N., Imbeaud, S., Pallier, K., Didelot, A., Roussel, H., Gibault, L., Fabre, E., Pimpec‐Barthes, F. L., Laurent‐Puig, P., et al. (2017) · Cancers · doi:10.3390/cancers9080101 · Cited by 78 · see citing works
Metallodrugs: an approach against invasion and metastasis in cancer treatment
González-Ballesteros, M. M., Mejía, C., & Ruíz-Azuara, L. (2022) · FEBS Open Bio · doi:10.1002/2211-5463.13381 · Cited by 79 · see citing works
KHOURY, N., EL-HAYEK, S., TARRAS, O., EL-SABBAN, M., EL-SIBAI, M., & RIZK, S. (2014) · International Journal of Oncology · doi:10.3892/ijo.2014.2635 · Cited by 77 · see citing works
The TGF-β Signalling Network in Muscle Development, Adaptation and Disease
Chen, J. L., Colgan, T. D., Walton, K. L., Gregorevic, P., & Harrison, C. A. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-27511-6_5 · Cited by 76 · see citing works
Atanasova, V. S., Russell, R. J., Webster, T. G., Cao, Q., Agarwal, P., Lim, Y. Z., Krishnan, S. M., Fuentes, I., Guttmann‐Gruber, C., McGrath, J. A., et al. (2019) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2019.01.011 · Cited by 75 · see citing works
TGF-β in the Bone Microenvironment: Role in Breast Cancer Metastases
Buijs, J. T., Stayrook, K. R., & Guise, T. A. (2011) · Cancer Microenvironment · doi:10.1007/s12307-011-0075-6 · Cited by 73 · see citing works
Yamamura, S., Matsumura, N., Mandai, M., Huang, Z., Oura, T., Baba, T., Hamanishi, J., Yamaguchi, K. D., Kang, H., Okamoto, T., et al. (2011) · International Journal of Cancer · doi:10.1002/ijc.25961 · Cited by 73 · see citing works
Li, C.-W., Wang, Q., Li, J., Hu, M., Shi, S.-J., Li, Z.-W., Wu, G.-L., Cui, H.-H., Li, Y.-Y., Zhang, Q., et al. (2016) · International Journal of Nanomedicine · doi:10.2147/ijn.s91975 · Cited by 89 · see citing works
Yan, C., Huo, X., Wang, S., Feng, Y., & Gong, Z. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.03.024 · Cited by 72 · see citing works
Targeting transforming growth factor-β signaling
Pennison, M. J., & Pasche, B. (2007) · Current Opinion in Oncology · doi:10.1097/cco.0b013e3282f0ad0e · Cited by 71 · see citing works
Park, N. R., Hoon, J., Jang, J. W., Bae, S. H., Jang, B., Kim, J., Hur, W., Choi, J. Y., & Yoon, S. K. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.06.077 · Cited by 70 · see citing works
Roudnicky, F., Zhang, J. D., Kim, B. K., Pandya, N. J., Lan, Y., Sach-Peltason, L., Ragelle, H., Strassburger, P., Gruener, S., Lazendic, M., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1911532117 · Cited by 66 · see citing works
High-Dose TGF-β1 Impairs Mesenchymal Stem Cell–Mediated Bone Regeneration via Bmp2 Inhibition
Xu, J., Liu, J., Gan, Y., Dai, K., Zhao, J., Huang, M., Huang, Y., Zhuang, Y., & Zhang, X. (2020) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3871 · Cited by 68 · see citing works
Microvesicles in Health and Disease
Inal, J. M., Ansa-Addo, E. A., Stratton, D., Kholia, S., Antwi-Baffour, S. S., Jorfi, S., & Lange, S. (2012) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-012-0165-2 · Cited by 68 · see citing works
Tumor-Specific Efficacy of Transforming Growth Factor-βRI Inhibition in Eker Rats
Laping, N. J., Everitt, J. I., Frazier, K. S., Burgert, M. E., Portis, M. J., Cadacio, C., Gold, L. I., & Walker, C. L. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-1811 · Cited by 67 · see citing works
Wang, D. M., Pun, C. C.-M., Huang, S., Tang, T., Ho, K. K., Rothrauff, B. B., Yung, P. S., Blocki, A. M., Ker, D. F. E., & Tuan, R. S. (2020) · The FASEB Journal · doi:10.1096/fj.201902377rr · Cited by 66 · see citing works
Myeloid-derived Suppressor Cells (MDSCs) in Gliomas and Glioma-Development
Kohanbash, G., & Okada, H. (2012) · Immunological Investigations · doi:10.3109/08820139.2012.689591 · Cited by 65 · see citing works
Restoration of TGF-β signalling reduces tumorigenicity in human lung cancer cells
Anumanthan, G., Halder, S., Osada, H., Takahashi, T., Massion, P. P., Carbone, D. P., & Datta, P. K. (2005) · British Journal of Cancer · doi:10.1038/sj.bjc.6602831 · Cited by 64 · see citing works
Self-citationGhafoor, S., Garcia, E. P., Jay, D. J., & Persad, S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26094364 · Cited by 68 · see citing works
Diwakar, R., Pearson, A. L., Colville‐Nash, P., Brunskill, N. J., & Dockrell, M. E. C. (2007) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00069.2006 · Cited by 63 · see citing works
de Souza, W. F., Fortunato-Miranda, N., Robbs, B. K., de Araujo, W. M., de-Freitas-Junior, J. C., Bastos, L. G., Viola, J. P. B., & Morgado-Díaz, J. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074994 · Cited by 62 · see citing works
Homeostatic Signaling by Cell–Cell Junctions and Its Dysregulation during Cancer Progression
Yu, Y., & Elble, R. C. (2016) · Journal of Clinical Medicine · doi:10.3390/jcm5020026 · Cited by 60 · see citing works
Vervoort, S. J., Lourenço, A. R., Vidaković, A. T., Mocholí, E., Sandoval, J. L., Rueda, O. M., Frederiks, C. L., Pals, C. E. G. M., Peeters, J. G. C., Caldas, C., et al. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky755 · Cited by 59 · see citing works
Pang, L., Li, Q., Wei, C., Zou, H., Li, S., Cao, W., He, J., Zhou, Y., Ju, X., Lan, J., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0112300 · Cited by 57 · see citing works
Ge, Q., Moir, L. M., Black, J. L., Oliver, B. G. G., & Burgess, J. K. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22295 · Cited by 58 · see citing works
Ansa-Addo, E. A., Lange, S., Stratton, D., Antwi-Baffour, S. S., Cestari, I. D. S., Ramirez, M. I., McCrossan, M. V., & Inal, J. M. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001656 · Cited by 58 · see citing works
Paldino, E., Tesori, V., Casalbore, P., Gasbarrini, A., & Puglisi, M. A. (2014) · BioMed Research International · doi:10.1155/2014/859871 · Cited by 57 · see citing works
Smith, K. T., Sardiu, M. E., Martin‐Brown, S., Seidel, C. W., Mushegian, A. R., Egidy, R., Florens, L. A., Washburn, M. P., & Workman, J. L. (2012) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m112.020255 · Cited by 55 · see citing works
Drug Development for Metastasis Prevention
Fontebasso, Y., & Dubinett, S. M. (2015) · Critical Reviews™ in Oncogenesis · doi:10.1615/critrevoncog.v20.i5-6.150 · Cited by 57 · see citing works
Wang, H., Chen, M., Sang, X., You, X., Wang, Y., Paterson, I. C., Hong, W., & Yang, X. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112154 · Cited by 56 · see citing works
Kirma, N. B., Hammes, L. S., Liu, Y., Nair, H. B. B., Valente, P. T., Kumar, S. N., Flowers, L., & TEKMAL, R. R. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-1991 · Cited by 56 · see citing works
O’Shea, T. M., Ao, Y., Wang, S., Wollenberg, A. L., Kim, J. H., Espinoza, R. A. R., Czechanski, A., Reinholdt, L. G., Deming, T. J., & Sofroniew, M. V. (2022) · Nature Communications · doi:10.1038/s41467-022-33382-x · Cited by 54 · see citing works
Yamada, A., Aki, T., Unuma, K., Funakoshi, T., & Uemura, K. (2015) · PLoS ONE · doi:10.1371/journal.pone.0120192 · Cited by 50 · see citing works
Targeting Nodal in malignant melanoma cells
Postovit, L.-M. M., Seftor, E. A., Seftor, R. E. B., & Hendrix, M. J. C. (2007) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.11.4.497 · Cited by 49 · see citing works
Overcoming treatment resistance in cancer: Current understanding and tactics
Wu, G. J., Wilson, G., George, J., Liddle, C., Hebbard, L., & Qiao, L. (2016) · Cancer Letters · doi:10.1016/j.canlet.2016.04.018 · Cited by 49 · see citing works
Sharma, P., Gupta, S., Chaudhary, M., Mitra, S., Chawla, B., Khursheed, M. A., Saran, N. K., & Ramachandran, R. (2020) · iScience · doi:10.1016/j.isci.2019.100817 · Cited by 48 · see citing works
Transforming Growth Factor-Beta (TGFβ) Signaling Pathway in Cholangiocarcinoma
Papoutsoglou, P., Louis, C., & Coulouarn, C. (2019) · Cells · doi:10.3390/cells8090960 · Cited by 48 · see citing works
Yu, X., Chen, X., Zheng, X., Zhang, J., Zhao, X., Liu, Y., Zhang, H., Zhang, L., Yu, H., Zhang, M., et al. (2018) · Hypertension · doi:10.1161/hypertensionaha.117.10350 · Cited by 47 · see citing works
Venkatraman, L., & Tucker‐Kellogg, L. (2013) · Liver International · doi:10.1111/liv.12231 · Cited by 46 · see citing works
Schneider, D., Tarantola, M., & Janshoff, A. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2011.07.016 · Cited by 46 · see citing works
Inhibition of TGFβ signaling and its implications in anticancer treatments.
Calone, I., & Souchelnytskyi, S. (2012) · PubMed · Cited by 46 · see citing works
- Authors
- Halder, S. K., Beauchamp, R. D., & Datta, P. K.
- Affiliations
- Vanderbilt University (US)
- Corresponding author
- Datta, Pran K.
- Venue
- Neoplasia
- Publisher
- Elsevier BV
- Published
- 2005-05
- Volume
- 7
- Issue
- 5
- Pages
- 509-521
- ISSN
- 1476-5586 (ISSN-L)
- PMC
- PMC1501161
- OpenAlex
- W1990842005
- Cited by
- 288
- References
- 37
- Citations by year
- 2026: 10 · 2025: 18 · 2024: 13 · 2023: 9 · 2022: 13 · 2021: 8 · 2020: 16 · 2019: 18 · 2018: 14 · 2017: 11 · 2016: 14 · 2015: 18 · 2014: 18 · 2013: 16 · 2012: 16
- FWCI
- 4.14
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Neoplasia (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Cancer Research Institute
- GlaxoSmithKline
- Virginia Marine Resources Commission
- National Cancer Institute (R01CA095195, 5P50CA90949, R01CA95195, R01CA069457, CA-69457, P50CA090949)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK52334, R01DK052334)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- SB431542, TGF-beta, anticancer agents, epithelial-mesenchymal transition, tumor invasion, angiogenesis, metastasis, apoptosis, anchorage-independent growth, colony formation, cell motility, vascular endothelial growth factor, TGF-beta signaling
- MeSH terms
- Receptor, Transforming Growth Factor-beta Type I, Animals, Antineoplastic Agents, Benzamides, Cell Adhesion, Cell Line, Cell Movement, Dioxoles, Enzyme Inhibitors, Humans, Mink, Models, Biological, Neoplasm Invasiveness, Neoplasm Metastasis, Neovascularization, Pathologic, Time Factors, Transcription, Genetic, Blotting, Western, Gene Expression Regulation, Neoplastic, Transforming Growth Factor beta, Apoptosis, Protein Serine-Threonine Kinases, Receptors, Transforming Growth Factor beta, Activin Receptors, Type I, Vascular Endothelial Growth Factor A, Cell Line, Tumor, Immunoprecipitation, Mice, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review