The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Morphological Analysis of Multinucleated Giant Cells Occurred in Experimental Autoimmune Myocarditis.
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SAEKI, M., TAKAHASHI-IWANAGA, H., IWANAGA, T., FUJITA, T., KODAMA, M., HANAWA, H., ZHANG, S., IZUMI, T. & SHIBATA, A. Morphological Analysis of Multinucleated Giant Cells Occurred in Experimental Autoimmune Myocarditis. Tohoku J. Exp. Med., 1994, 172 (3), 195-204-Our previous study reported the rich existence of multinucleated giant cells in an autoimmune myocarditis experimentally induced in rats. The present study investigated the histochemical and ultrastructural characteristics of these giant cells. Histochemistry for an acid phosphatase clearly demonstrated multinucleated giant cells dispersed at the inflammatory foci. Ultrastructurally, the giant cells were shown to be single cells, but not clustered cells. Their ultrastructural characteristics were very similar to the basic features of macrophages, except that the giant cells were poor in lysosomes and phagosomes. It was noticeable that some macrophages possessed three or more nuclei, displaying an intermediate form between mononuclear macrophages and multinucleated giant cells. These findings suggest that the giant cell in the experimental autoimmune myocarditis is a single multinucleated cell, and possibly derived from macrophages by cell-to-cell fusion.
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In giant cell myocarditis and cardiac sarcoidosis, macrophages are a significant contributor to the formation of multinucleated giant cells or granulomas.
“In well-known forms of autoimmune myocarditis such as giant cell myocarditis and cardiac sarcoidosis, macrophages have been identified as a significant contributor to the formation of multinucleated giant cells or granulomas”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [113]
The Discussion (page not provided) says that multinucleated giant cells in the rat model may form through macrophage fusion and that giant cells in granulomas are generally understood to form this way. It does not establish this mechanism specifically in cardiac sarcoidosis, and its finding in experimental myocarditis does not establish it for human giant cell myocarditis. (LLM, conf=0.86)
Experimental — accuracy not yet measuredMultinucleated giant cells stain positive for macrophage or other myeloid cell markers in clinical settings and animal models of giant cell myocarditis.
“multinucleated giant cells stained positive for macrophage or other myeloid cell markers in both clinical settings and animal models.”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [113]
The Results report positive acid-phosphatase staining in giant cells from rats with experimental autoimmune myocarditis, and the Discussion identifies acid phosphatase as a macrophage-specific enzyme. The paper mentions human giant cell myocarditis but does not report marker staining in clinical cases, so it supports the animal-model portion only. (LLM, conf=0.88)
Experimental — accuracy not yet measuredMacrophages play a pivotal role in giant cell myocarditis.
“Macrophages also play a pivotal role in giant cell myocarditis”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [113]
The Discussion reports active macrophage phagocytosis in a rat model of experimental autoimmune myocarditis and suggests that giant cells may form by macrophage fusion. It does not establish that macrophages play a pivotal role in giant cell myocarditis generally; it describes the giant cells’ functional significance as unresolved and considers the experimental disease to be mediated by lymphocytes. (LLM, conf=0.86)
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Citations
Cites
Giant cell myocarditis: evidence for the macrophage origin of the giant cells.
Theaker, J. M., Gatter, K. C., Heryet, A., Evans, D. J., & McGee, J. O. (1985) · Journal of Clinical Pathology · doi:10.1136/jcp.38.2.160 · Cited by 39
Flagged first, then by citations
Research works printed but not linked: 2
- van Furth, R. (1992) Production and migration of monocytes and kinetics of macrophages. In: Mononuclear Phagocytes, edited by R. van Furth, Kluwer Aca- demic Publishers, Netherlands, pp. 3-12.
- Wynne, J. & Braunwald, E. (1992) The cardiomyopathy and myocarditis: Toxic, chemical and physical damage to the heart. In: Heart Disease, edited by E. Braunwald, 4th ed., Saunders, Philadelphia, pp. 1398-1450.
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Autoimmune Myocarditis, Old Dogs and New Tricks.
Won, T., Song, E. J., Kalinoski, H. M., Moslehi, J. J., & Čiháková, D. (2024) · Circulation Research · doi:10.1161/circresaha.124.323816 · Cited by 51
Metadata
- Authors
- SAEKI, M., TAKAHASHI-IWANAGA, H., IWANAGA, T., FUJITA, T., KODAMA, M., HANAWA, H., ZHANG, S., IZUMI, T., & SHIBATA, A.
- Affiliations
- Niigata University (JP)
- Department of Anatomy, Niigata University School of Medicine
- Venue
- The Tohoku Journal of Experimental Medicine
- Publisher
- Tohoku University Medical Press
- Published
- 1994
- Volume
- 172
- Issue
- 3
- Pages
- 195-204
- ISSN
- 0040-8727 (ISSN-L)
- 1349-3329
- OpenAlex
- W2087949236
- Cited by
- 8
- References
- 1
- Citations by year
- 2026: 1 · 2024: 1 · 2018: 1 · 2015: 1
- FWCI
- 0.93
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Tohoku Journal of Experimental Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Viral Infections and Immunology Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Keywords
- multinucleated giant cells, experimental autoimmune myocarditis, macrophages, cell fusion, ultrastructure, lysosomes, phagosome, myocarditis, rat model
- MeSH terms
- Acid Phosphatase, Animals, Autoimmune Diseases, Cell Fusion, Disease Models, Animal, Macrophages, Male, Myocarditis, Rats, Inbred Lew, Giant Cells, Rats
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